Objective To investigate the effect of intensive atorvastatin therapy on coronary reperfusion of patients with unstable angina and diabetes undergoing percutaneous coronary intervention (PCI) and its safety.Methods One hundred and thirty-seven unstable angina patients with diabetes were underwent percutaneous coronary intervention in Zhumadian Central Hospital from July 2011 to July 2013.Patients were randomly divided into regular and intensive groups.Patients in regular group (n =59) were received atorvastatin 20 mg/d after admission and in intensive group (n =78) were received atorvastatin 80 mg 2 h before PCI beside atorvastatin 20 mg/d.The information of thrombolysis in myocardial infarction flow grade and perioperative myocardial infarction(MI) were recorded.The level of liver enzyme,serum creatinine and creatine kinase were measured.Results Compared with the regular group,the postoperative incidence of no reflow,slow flow and perioperation MI was lower in intensive group.The rate of MI in intensive group was 5.1％ (4/78),lower than that in regular group (17.0％ (10/59) ;x2 =5.44,P =0.02)).There was no significant difference in terms of liver enzymes,serum creatinine and creatine kinase between two groups (P ＞ 0.05).Multiple factors correlation analysis showed that after adjusted gender,age,smoking,hyperlipidemia,lesions and important branch after the involvement of expansion and other factors,intensive statin therapy was the independent prognostic factor to avoid the occurrence of no reflow,slow flow and peri operation period of myocardial infarction.Conclusion The intensive atorvastatin therapy can improve coronary perfusion without increasing the risk of side-effect for unstable angina patients with diabetes undergoing PCI.

The role of neuroprotection in the treatment of acute cerebrovascular disease is reviewed. Various neuroprotective strategies include ion channel modulators,anti excitotoxic agents,free radical scavengers,neurrotrophic factors,hypothermia,gene therapy and stem cells. The various agents aim to prevent the progression of ischemic cascade therefore reducing brain injury through more than one point in the ischemic cascade. Clinical effectiveness of most of the strategies has not been proven in clinical trials. Some of which had to be abandoned due to adverse effects outweighing the beneficial effects. At least six neuroprotective agents based on various mechanisms are in phase Ⅲ of clinical trials. The most promising appear to be free radical scavengers and anti excitotoxic agents.

Intimal hyperplasia is an early presentation in the development of atherosclerosis.Vascular smooth muscle cell migration and proliferation have a very important position in this process.GelatiBase,an extracellular protcolytic enzyme,is playing important roles in various physiopalhological processes.This article reviews the relationship between gelatimse and vascular smooth muscle cell migration in the process of intimal hyperplasia.

Digital subtraction angiography has long been recognized as a gold standard for detecting cerebrovascular lesions.With the development of CT techniques,CT angiography(CTA)has been widely used in intracranial and extracranial vascular evaluation.This article reviews the development of CTA technique and its application in the diagnosis of cerebrovascular lesions.

Ischemic cerebrovascular disease accounts for about 70％ of all types of stroke,and large vessel occlusive stroke is a major subtype of ischemic stroke.Currently,endovascular revascularization has been widely used in the treatment of large vessel occlusive stroke.The development of multi-modal neuroimaging has provided technical support to this.This article reviews the roles of neuroimaging in endovascular recanalization in patients with ischemic stroke.

Most compounds in blood are blocked from flowing into brain by blood-brain barrier(BBB) to keep central nerve system normal, but this barrier will be open in different diseases with different mechanisms. As these mechanisms are understood more and more clearly, it will do help to protect blood-brain barrier and treat diseases which are correlative to blood-brain barrier. At the same time, it may also be helpful to let drugs entering central nerve system through BBB.

Transient ischemic attack(TIA) is one frequent type of acute ischemic cerebral vascular disease.Much advancement has been made in the definition,aetiology,diagnosis and therapy of TIA in recent years.Carotid endarterectomy and carotid angioplasty and stenting is the latest therapy of carotid artery stenosis.

Fibroblast grow factors are important regulators of the embryonic and adult central nervous system during developmental processes and adult physiology.FGF control cell migration and establishment of the anterior-posterior body axis of the neural plate during gastrulation.At later shaping stage of the brain,FGF function in those organs and tissues control the morphogenesis and differentiation.During adult and injured in the adult brain,FGF contain the active hyperplasia of the adult stem cells and promote regeneration and repair in the central nervous system.This article mainly reviews the function of FGF family members in the central nervous system.

Transient visual disturbance(TVD) is caused by artery stenosis,or artery embolism and migraine,which lead to reduction of eye blood flow,retinal ischemia and hypoxia.Major clinical manifestations include amaurosis fugax and visual transient ischemic attacks(TIA).The present research situation and progression of TVD were reviewed.

Carotid artery stenting (CAS) for treating carotid artery stenosis is a recent developed technique which is less invasive and complications. This paper reviewed the progress, procedure, and complications of carotid artery stenting.