To study the effectiveness of combined Acupuncture and Chinese medicine on depression. Methods: Ninety-eight patients were randomly divided into two groups. The treatment group of 52 cases were treated by scalp acupuncture and electroacupuncture, Baihui (GV 20), Shenting (GV 24), Taichong (LR 3), Neiguan (PC 6),Guanyuan (CV 4), Zusanli (ST 36), Sanyinjiao(SP 6), plus Chinese medicine, modified Xiaoyao Powder (a decoction for soothing liver and relieving depression) and the control group of 46 cases, only with Chinese medicine, modified Xiaoyao Powder. Results: The total effective rate was 94.2% in the treatment group and 78.26% in the control group; with a significantdifference between two groups(P＜0.05) Conclusion: Acupuncture plus Chinese medicine has a marked effect on depression.