Objective:To discuss the curative effect of Saccharomyces boulardii Sachets in the treatment of children with hand-foot-mouth disease (HFMD) and explore the influence on serum procalcitonin (PCT) and interleukin-6 and 12 (IL-6 and 12) levels. Methods:Totally 88 cases of children with HFMD were selected and divided into the observation group and the control group at ran-dom. The children in the two groups were given routine medical treatment, such as anti-virus, defervesce, nutrition support and etc. The children in the observation group were additionally given 0. 25g Saccharomyces boulardii Sachets, once a day with warm boiled wa-ter. The changes in serum PCT, IL-6 and 12 levels of the children before and 72 hours after the medical treatment were observed, and the clinical curative effect and adverse reactions were compared as well. Results: After the 72-hour medical treatment, serum PCT, IL-6 and 12 levels of the children in the two groups were declined in different degrees (P<0. 05 or P<0. 01), and the declining rate in the observation group was much higher than that in the control group (P<0. 05). The total clinical efficiency of the observation group was also much higher than that of the control group. The adverse reactions appeared respectively in the control group and the ob-servation group during the medical treatment show no significant difference(P>0. 05). Conclusion:Saccharomyces boulardii Sachets used as adjunctive therapy show favorable curative effect and safety in the treatment of children with HFMD, which can reduce serum PCT, IL-6 and 12 levels, and inhibit the immune inflammatory reaction process in children.

This article introduces the mechanisms and clinical implications of high-intensity focused ultrasound (HIFU) for the treatment of malignant tumor, and discusses the efficacy,limitations, and prospects of this technology. Dispite the recent advances, the clinical application of HIFU is still limited. Multiple trials are currently underway worldwide to determine its efficacy.

Cranial irradiation is routinely used for the treatment of almost all brain tumors,but it may cause disastrous injury in brain,especially in the hippocampus that has cognitional and emotional regulation functions.Several studies have investigated the mechanisms of radiation-induced hippocampal dysfunctions such as hippocampal neurogenesis,neurotrophin and neuroinflammation,and provided effective prevention strategies such as exercise,environmental enrichment,anti-inflammatory and intrahippocampal transplantation of neural stem cells.This review discussed the curent progresses and challenges of hippocampal dysfunction induced by cranial irradiation and provided new insights for preclinical and clinical researches.

OBJECTIVE:To provide reference for compliance and rationality of drug use. METHODS:Cases of all kinds of patients’factor-induced irrational drug use were interviewed and analyzed. RESULTS:Patient factors included over-dependence on injection,cognition deficiency to characteristics and treatment course of their diseases,over-worry about ADR and obstinate adherence to their own drug habit. CONCLUSION:It’s necessary to strengthen pharmaceutical administration and pharmaceutical care by publicizing,communicating and conducting to strengthen the compliance and rationality.

Objective To investigate the clinical effect of vitapex paste in the treatment of deciduous teeth with periapical inflammation.Methods 112 children with chronic apicitis of deciduous teeth were divided into two groups randomly and averagely.The research group used vitapex paste,while the control group used zinc oxide eugenol paste.The clinical effects of the 2 groups were compared.Results Compared to the control group,the response to root canal filling of the research group was much weaker ( 10.7％ to 25.0％ ),which had statistical difference ( x2 =3.02,P =0.0 1 1 ).There wasalso significant difference betweenthe success rateofthetwogroups after 1 year followed up( x2 =5.16,P =0.004).Conclusion sing vitapex paste for root canal filling had a higher success rate and a weaker respose to root canal filling.

Through demonstrating the satisfaction evaluation system of Singapore hospitals,the article analyzed the differences between the satisfaction evaluation system of Singapore and the system made by Shanghai Municipal Commission of Health and Family Planning.It was concluded that the humanized evaluation methods should be highlighted,the conformity of establishment of evaluation system and policy be focused on,staff incentive mechanism be focused on and perfected,and patients' expectation indicator and perceived quality be considered as strategic tools to improve the healthcare system performance.

OBJECTIVE:To evaluation the effects of the regulatory measures on the clinical application of quinolones. METHODS: The consumption sum and its proportion in the total in major clinical departments before and after the enforcement of the regulatory measures were analyzed, which were compared with the data from the synchronous case files so as to evaluate the rationality of the use of quinolones. RESULTS & CONCLUSION: Quinolones were predominantly used in six departments including the department of respiratory diseases. After the initiation of the regulatory measures, the consumption sum of quinolones decreased in most departments, suggesting the positive effect of the regulatory measures.

ObjectiveTo study the effects of Shuxuening Injection on brain blood dynamics and neurological function in patients with vascular dementia.Methods60 patients with vascular dementia were assigned to two groups.31 patients were treated with routine therapy of internal medicine and Shuxuening Injection for two weeks,other 29 patients were treated with routine therapy of internal medicine only.The changes of brain blood dynamics,activity of daily living(ADL) and P300 before and 4 weeks after treatment were observed.ResultsThere were significant differences in brain blood dynamics,ADL and P300 after the treament between these two groups(P<0.05 or P<0.01).ConclusionShuxuening Injection can improve the brain blood dynamics in patients with vascular dementia obviously and accelerate neurological functional recovery.

Objective: To observe the sex hormone levels in adolescent male acne patients with normal serum testosterone, and to evaluate the curative effect of antiandrogen therapy. Methods: Totally 40 adolescent male acne patients with normal serum testosterone were evenly randomized into two groups, the treatment group received finasteride plus life-style intervention, and the control group received life-style intervention only. The curative effects were compared between the two groups, and the levels of serum testosterone, dihydrotestosterone (DHT), free testosterone (FT), sex hormone binding globulin (SHBG), and estradiol (E2), and the adverse effects were observed before and after treatment. The curative effects in the treatment group were also observed 3 months after drug withdrawal. Another 40 healthy adolescent males served as normal group for comparison of the baseline hormone levels with ance patients. Results: The patients in our group had significantly higher levels of body fat content, E2 (P<0.05), DHT, and FT (P<0.01), and lower level of SHBG (P<0.05) compared with those in the normal control group. The overall effective rate of the treatment group was 90%, which was significantly higher than that of the control group (25%, P<0.01); the effective rate of the treatment group was 85% 3 months after drug withdrawal. The levels of DHT (P<0.01) and FT (P<0.05) in the treatment group were significantly decreased and the levels of SHBG was significantly increased (P<0.05) after treatment. There were no severe adverse effects in both groups. Conclusion: The adolescent male acne patients with normal serum testosterone have higher body fat content, DHT, FT, E2 and lower SHBF levels. The therapy using finasteride plus life-style is effective) it can greatly improve the serum level of SHBF and reduce adverse effects, with low recurrent rate after drug withdrawal.

Background The measurement of the extraocular muscle is critical for the diagnosis of extraocular muscle diseases,but conventional medical imaging techniques present some shortcomings because of the contact pattern.The anterior segment optical coherence tomography (OCT) is thought to be an in vivo noninvasive optical diagnostic imaging method.Objective This clinical study attempted to seek an available approach to the evaluation of the anatomic structure of human horizontal rectus insertion with Visante OCT.Methods One hundred and fourteen eyes of 58 subjects were included in this study and were divided into the low refractive power group (≤-3.00 D) with 43 eyes,moderate refractive power group(＞-3.00 D-≤-6.00 D) with 49 eyes and high refractive power group(＞-6.00 D) with 22 eyes.The horizontal rectus insertion distance to the scleral spur and its thickness were measured by Visante OCT.The correlation of the refractive power with the rectus insertion distance or thickness was analyzed.Written informed consent was obtained from each subject before medial assessment.Results The average distance from the scleral spur to the lateral and medial rectus insertion were (5.23±0.50)mm and (3.81±0.46)mm respectively.The average thickness of the lateral and medial rectus insertions were (0.39±0.06)mm and (0.39±0.06)mm respectively,showing no significant differences in comparison with those of ultrasound biomicroscopy (P=0.338,P=0.759).The lateral and medial rectus insertion distances were (5.25±0.45)mm and (3.74±0.53)mm in the low refractive power the group,(5.22±0.60)mm and (3.81±0.42)mm in the moderate group and (5.20±0.35)mm and (3.90±0.42)mm in the high refractive power group,presenting inconsiderable difference among these three groups(lateral rectus: χ2=0.054,P=0.974;medial rectus: F=0.508,P=0.604).The thickness of the lateral and medial rectus insertions were (0.41±0.06)mm and (0.40±0.06)mm in the low refractive power group,(0.40±0.07)mm and (0.37±0.07)mm in the moderate refractive power group,(0.36±0.05)mm and (0.39±0.05)mm in the high refractive power group with a significant difference among lateral rectus (F=4.922,P=0.009) but not medial rectus (F=2.152,P=0.125).The lateral rectus insertions thickness in the high refractive power group was thinner than that in low refractive power group (P＜0.05).A positive correlation was found between refractive power and the thickness of lateral or medial rectus insertions (r=0.284,P＜0.01).Conclusion Visante OCT is a uscful way in measuring the distance and thickness of the extraocular muscles.Lateral rectus insertions thickness tends to be thinner with the worsening of myopia,which is obvious in high myopia.