1.Relationship of angiotensin-converting enzyme, angiotensinogen and endothelial nitric oxide synthase gene polymorphisms with coronary disease in aged people
Xi LIANG ; Yugang DONG ; Xili YANG ; Guang YANG ; Jinhuan CUI
Chinese Journal of Geriatrics 2000;0(06):-
Objective To evaluate the predisposition effects of angiotensin-converting enzyme (ACE) ,angiotensinogen (AGT) and endothelial nitric oxide synthase (eNOS) gene polymorphisms on coronary disease (CHD) as well as their possible synergistic effect in the development of CHD in Chinese aged people. Methods The study included 191 subjects (100 CHD and 91 controls). Gene chip technology was performed. The allele frequency and genotype distribution were compared between groups. Results A significantly higher frequency of the DD genotype of ACE gene was observed in CHD group (28.0% vs 15. 4%, P0. 05). Subjects carrying ACE DD and AGT TT genotypes or those carrying AGT TT and eNOS TT genotypes showed a stronger association withCHD(OR=2. 9, P
2.Observation on Action of Zheng Xuan Yin on Improvement of Blood Circulation of Cerebral Ischemia in Rats with ~(123)I- IMP Tracer.
Jingyi WANG ; Yasihiluo MAATA ; Nauoya HATUOI ; Xili CUI ; ET AL ;
Journal of Traditional Chinese Medicine 1992;0(12):-
4VO rat models were used. The remedy Zhenxuanyin, composed of Rhizoma Gastrodia, Poria, Radix Lugustici Chuanxiong, divided into 3 dosages, were infused 30 minutes after total cerebral infarction., The cerebralblood flow was marked with 123 I- IMP 24 hours later. Results showed Zhenxuanyin in dosages of 0. 03g/kg, 0. 3g/kg, 1g/kg, 3g/kg all markedly increased cerebral blood flow in which the dose 0. 3g/ kg can restore the blood flow to a normal level.