Objective To study installation, construction design and infection control of CSSD (central sterile supply department)equipment. Methods The merits of advanced CSSD building layout was studied as reference. International advanced disinfection & sterilization equipment was used. The laminar flows of the air in sterile room were purified. All apparatus and articles were controlled by computers. The third zone was equipped with full-automatic cleaning disinfection & sterilization apparatus. Results The quality and index all meet the requirement in construction design and infection control. Conclusion The design meets modern disinfection standards and can control the infection effectively.