1.Influence of effective analgesia on liver function recovery in patients undergoing hepatectomy
Jianjun LIU ; Xijing YUAN ; Heping KAN
The Journal of Practical Medicine 2017;33(15):2517-2520
Objective To investigate the influence of pain on liver function recovery after hepatectomy Methods Clinical data of 257 patients with primary hepatocellular carcinoma were analyzed retrospectively. The patients were divided into effective analgesia group(NRS ≤ 3 points)and ineffective analgesia group(NRS > 3 points)according to the digital hierarchy(NRS). The serum liver function indexes including ALT,AST,TBiL, ALB and PT were compared in 2 groups. Results There was no significant difference in preoperative liver function between 2 groups but the levels of ALT ,AST ,PT and TBIL at 1st ,3rd ,5th and 7th days postoperatively were lower in effective analgesia group than those in ineffective analgesic group after surgery(P<0.05). The incidence of the delay of liver function was lower in effective analgesia group than that in ineffective analgesic group. Conclusion Effective analgesic treatment can reduce liver damage and accelerate liver function recovery.
2.Histopathological changes of rat injured spinal cord following olfactory ensheathing cell transplantation
Guoyu WANG ; Xijing HE ; Puwei YUAN ; Haopeng LI ; Rui CHANG
Chinese Journal of Tissue Engineering Research 2010;14(6):1053-1057
BACKGROUND: There are no effective treatments for spinal cord injury. Transplantation of olfactory ensheathing cells (OECs) has achieved great progress in repairing spinal cord injury. OBJECTIVE: To observe the effect of OECs transplantation on pathological and ultrastructural alterations of spinal cord, and the role in spinal cord injury developing.METHODS: A total of 60 SD rats were randomly divided into blank, model, transplantation and DF12 groups, with 15 animals in each group. The entire vertebral plate of T_(10), and partial vertebral plate of T_9 and T_(11) of blank group were cut open, and gelatin sponge was used for hemostasis. In the model group, the spinal cord was excised. In the transplantation and DF12 groups, OECs and DF12 culture solution were injected following spinal cord excision. The incision was sutured. Two rats from each group were anesthetized 1, 3, 7, 14, 28, 42, and 56 days following injury, and injured areas were observed by light microscopy and electron microscopy. RESULTS AND CONCLUSION: Following spinal cord injury, pathological and ultrastructural changes occurred, such as hemorrhage, edema, degeneration, necrosis, cavitation, gliacyte proliferation and nerve fiber regeneration. OECs transplantation attenuated neuronal and nerve fiber necrosis, relieved degree of pathological reaction, protected injured neurons, prevented gliacyte proliferation and increased nerve fiber regeneration. Results show that OECs transplantation ameliorated pathological reactions and promoted spinal cord injury repair.
3.Efficiency Analysis of Humanism in Nursing Management of Patients with Spinal Cord Injury
Huiru LYU ; Xiaoying GUO ; Ke LI ; Jing CHEN ; Cuicui YUAN ; Xijing HE
Chinese Medical Ethics 2015;(4):596-598
Objective:To explore the effectiveness of humanism concept in the management of patients with spi-nal cord injury care.Methods:Choose between January 2011 and February 2011 hospitalized in our hospital 112 cases of spinal cord injury patients, randomly divided into control group and observation group ( 56 cases) , com-pared two groups of nursing effect.Control group routine nursing management, observation group will humanistic nursing management idea runs through in the routine nursing management.Results:Aware of knowledge about health education group is significantly higher than the control group, patients satisfaction survey in nursing, be-tween the two groups statistically significant depression levels lower than the control group.Conclusions:In the nursing management of patients with spinal cord injury in the application of humanistic nursing concept effect is good, not only improve the effect of the nursing, and obviously improve the patient′s satisfaction, promote the pa-tient′s psychological adaptability.
4.Clinical and electrophysiological features of epilepsy combined with neck myoclonus
Gengyao HU ; Na YUAN ; Zezhi WANG
Journal of Apoplexy and Nervous Diseases 2021;38(11):998-1000
To describe the electroclinical features of epilepsy and neck myoclonus.Methods We searched the EEG database using the terms “epilepsy” and “neck myoclonus” over a 2-year period from January 2018 to January 2020 in the Xijing Hospital,Xi’an,China. The clinical and electrophysiological characteristics were studied. Results Four patients with epilepsy and neck myoclonus were male.They were diagnosed with genetic generalized epilepsy,of which 3 patients were epilepsy of generalized tonic-clonic seizures alone,1 patient was epilepsy of eyelid myoclonia with absences.The mean age at epilepsy onset was 9~27 years. Epilepsy and valproate treatment preceded neck myoclonus in two patients,and the neck myoclonus disappeared after discontinuation of valproate in one of them. A total of 254 neck myoclonus were recorded,92.5% of the events occurred during Rapid eye movement sleep,and then non-rapid eye movement 1 sleep. Conclusion Neck myoclonus may be more common in genetic generalized epilepsy. Video electroencephalography monitoring may be helpful to confirm the type of the myoclonus. The electroclinical features and mechanisms of the coexistence of epilepsy and neck myoclonus need further study.
5.Clinical analysis of hepatolenticular degeneration in 111 patients.
Yuan-yuan NIAN ; Xian-mei MENG ; Hong-bo ZHANG
Chinese Journal of Hepatology 2013;21(2):149-150
Adolescent
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Adult
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Child
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Child, Preschool
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Early Diagnosis
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Female
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Hepatolenticular Degeneration
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diagnosis
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Humans
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Male
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Young Adult
6.Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis.
Protein & Cell 2012;3(3):173-181
Atherosclerosis is a chronic, inflammatory disorder characterized by the deposition of excess lipids in the arterial intima. The formation of macrophage-derived foam cells in a plaque is a hallmark of the development of atherosclerosis. Lipid homeostasis, especially cholesterol homeostasis, plays a crucial role during the formation of foam cells. Recently, lipid droplet-associated proteins, including PAT and CIDE family proteins, have been shown to control the development of atherosclerosis by regulating the formation, growth, stabilization and functions of lipid droplets in macrophage-derived foam cells. This review focuses on the potential mechanisms of formation of macrophage-derived foam cells in atherosclerosis with particular emphasis on the role of lipid homeostasis and lipid droplet-associated proteins. Understanding the process of foam cell formation will aid in the future discovery of novel therapeutic interventions for atherosclerosis.
Acyltransferases
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metabolism
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Apoptosis Regulatory Proteins
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metabolism
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Atherosclerosis
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metabolism
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pathology
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Cholesterol
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metabolism
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Foam Cells
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cytology
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metabolism
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Humans
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Lipid Metabolism
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physiology
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Macrophages
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cytology
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immunology
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Membrane Proteins
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metabolism
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Perilipin-2
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Peroxisome Proliferator-Activated Receptors
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metabolism
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Sterol Regulatory Element Binding Proteins
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metabolism
7.Impairment of Autophagic Flux After Hypobaric Hypoxia Potentiates Oxidative Stress and Cognitive Function Disturbances in Mice.
Shuhui DAI ; Yuan FENG ; Chuanhao LU ; Hongchen ZHANG ; Wenke MA ; Wenyu XIE ; Xiuquan WU ; Peng LUO ; Lei ZHANG ; Fei FEI ; Zhou FEI ; Xia LI
Neuroscience Bulletin 2024;40(1):35-49
Acute hypobaric hypoxic brain damage is a potentially fatal high-altitude sickness. Autophagy plays a critical role in ischemic brain injury, but its role in hypobaric hypoxia (HH) remains unknown. Here we used an HH chamber to demonstrate that acute HH exposure impairs autophagic activity in both the early and late stages of the mouse brain, and is partially responsible for HH-induced oxidative stress, neuronal loss, and brain damage. The autophagic agonist rapamycin only promotes the initiation of autophagy. By proteome analysis, a screen showed that protein dynamin2 (DNM2) potentially regulates autophagic flux. Overexpression of DNM2 significantly increased the formation of autolysosomes, thus maintaining autophagic flux in combination with rapamycin. Furthermore, the enhancement of autophagic activity attenuated oxidative stress and neurological deficits after HH exposure. These results contribute to evidence supporting the conclusion that DNM2-mediated autophagic flux represents a new therapeutic target in HH-induced brain damage.
Mice
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Animals
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Hypoxia
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Oxidative Stress
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Autophagy
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Cognition
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Sirolimus/therapeutic use*
8.Diagnosis and treatment progress of malignant mesothelioma of the tunica vaginalis testis
Hao ZHANG ; Wanxiang ZHENG ; Lei ZHANG ; Jianlin YUAN
Journal of Modern Urology 2023;28(2):171-175
Malignant mesothelioma of the tunica vaginalis testis (MMTVT) is a rare tumor. At present, there are still many disputes in its epidemiology, pathogenesis, selection of diagnostic methods, treatment and prognosis. Asbestos exposure, ionizing radiation and chromosome abnormalities are the risk factors of MMTVT. Immunohistochemistry, ultrasonography and electron microscope can be used for the diagnosis and aggressive surgery is the main treatment method. The development of endoscopic surgery, multi-disciplinary treatment (MDT), tumor targeted therapy and immunotherapy will bring more benefits to MMTVT patients.
10. Research progress on risk factors for poor response of ursodeoxycholic acid in primary biliary cholangitis
Zhou YUAN ; Gui JIA ; Ying HAN
Chinese Journal of Hepatology 2019;27(1):73-76
Primary biliary cholangitis (PBC) is an autoimmune-mediated chronic cholestatic liver disease. Ursodeoxycholic acid (UDCA) is a first-line drug approved by the Food and Drug Administration for the treatment of PBC. It can effectively improve serum biochemical indicators, delay histological progress, and prolong the survival of non-transplant patients. However, around 40% of patients with PBC have a poor response to UDCA with a poor outcome. Early identification of patients with poor biochemical responses and timely second-line treatment may alter the course of the disease. This article summarizes the risk factors for the poor response of UDCA in the PBC.