Objective To study the influences of endogenous testosterone on vascular endothelial cell function and structure in rabbits of balloon injury. Methods Twenty male rabbits were randomly divided into two groups: castrated group and control group.The former group animals were castrated and the later group animals received sham operation. All animals were performed with deendothelializing balloon injury in the right iliac artery. Nitric oxide (NO) and endothelin-1 (ET-1) were measured at different intervals during the experiment. After 2 weaks of endothelial denudation all animals were killed, and endothelin structure and morphological changes were observed with electron microscope and HE staining. Results There weren′t siginificant differences of plasma NO and ET-1 levels between the two groups, but plasma NO and ET-1 levels of the castrated group 2 weaks after endothelial denudation recovered to the levels before castration, while they didn′t in the control group. The extent of reendothelialization and intimal area of the harvested segments were similar between the two groups. Conclusion The decrease of endogenous testosterone level did not affect endothelial cell structure, but tended to protect function of injured endothelium.

Objective To evaluate the application of three dimensional time-of-flight (3D-TOF) MRA in screening intracranial aneurysms in the population of Wenling community. Methods A total of 2 124 patients with suspicious intracranial aneurysm in Wenling community, who received 3D-TOF MRA and three dimensional digital subtraction angiography(3D-DSA) during the period from September 2011 to August 2012, were enrolled in this study. The epidemic data of intracranial aneurysm in Wenling community were analyzed, the effectiveness of 3D-TOF MRA in detecting intracranial aneurysm was assessed, and the consistency between 3D-TOF MRA and 3D-DSA (regarded as the golden standard) in detecting intracranial aneurysm was statistically analyzed. Results The results of 3D-TOF MRA showed that the morbidity of intracranial aneurysm in the population of Wenling community was 6.87% (146/2 124), among which the morbidities in males and females were 48.63% (n=71) and 51.37% (n=75) respectively; the mean age of patients was (41.2±11.6) years old. The accompanying diseases included hypertension, diabetes mellitus, arteriosclerosis and cerebrovascular lesions. 3D-TOF MRA examination revealed 149 intracranial aneurysms, among which misdiagnosis was made in 5 patients and missed diagnosis in 2 patients. The sensitivity, specificity and accuracy of 3D-TOF MRA in diagnosing intracranial aneurysm were 98.63% (144/146), 99.72%(1 773/1 778) and 99.67%(2 117/2 124) respectively. No statistically significant difference in measuring the longitudinal diameter and neck width of intracranial aneurysms existed between 3D-TOF MRA and 3D-DSA examinations (P>0.05). Conclusion In detecting intracranial aneurysm, 3D-TOF MRA carries higher sensitivity, specificity and accuracy, and its non-invasive advantage is more suitable for the screening of intracranial aneurysms.