Objective To research the relationship between hypertensive disorder complicating pregnancy and serum free estriol 3 (FE3) and explore its impact on pregnancy outcome.Methods Clinical data of 117 hypertensive disorder complicating pregnancy and 165 normal pregnant women were retrospectivly analyzed.Chemiluminescence immunoassay determination of maternal serum FE3 also had been conducted.Then analyzing the correlation between hypertensive disorder complicating pregnancy and FE3 and its impact on pregnancy outcomes.Results LDL cholesterol and the level of creatinine of observation group were significantly lower than the control group(t =3.129,9.372,all P ＜ 0.05),while blood pressure,triglycerides,HDL,and 24-hour urinary protein content were significantly higher than control groug(t =7.361,2.398,2.833,all P ＜ 0.05).The FE3 level of the observation group were significantly lower than the control group (t =2.913,P ＜ 0.05).There was a significant positive correlation between the FE3 level of normal pregnant women and their gestational age (r =0.937,P ＜ 0.05).The probabilities of premature birth,premature rupture of membranes,postpartum hemorrhage,and neonatal asphyxia of observation group were significantly higher than amtrol group (x2 =3.912,3.879,4.267,6.935,all P ＜ 0.05).Conclusion There is a significant correlation between hypertensive disorder complicating pregnancy and FE3,which has an important significance on monitoring the health status of pregnant women and the fetal-placental function.

Objective To explore the connections between psychological intervention and pregnancy outcome of preg nant women with advanced maternal age. Methods All 196 primipara with advanced maternal age who received antenatal examination and gave birth to children in our hospital were randomly allocated to observation group(n=98)and control group(n=98). The control group received routine nursing while the observation group received psychological interven-tion. Mental conditions, pregnancy outcome and related complications were compared and analyzed between the two groups of pregnant women before and after the intervention. Results Scores of SCL-90 and Athens insomnia scale in the observation group after the intervention were significantly lower than those in the control group (P<0.01);all new-borns delivered by primipara with advanced ma ter nal age were alive; rate of natural childbirth in observation group(70.41%)was significantly higher than that in the control group (27.55%),and the difference was statistically signifi-cant (χ2=21.562,P<0.01). Rate of cesarean section in the control group (68.37%) was significantly higher than that in the observation group (27.55%), and the difference was statistically significant (χ2=15.208, P<0.01). Incidence of complications such as hypertension, premature birth, postpartum hemorrhage and full-term infants with low birth weight in the observation group were all lower than those in the control group,and the differences were statistically sig-nificant(P<0.05). Conclusion Psychological intervention is capable of effectively improving the mental status of preg-nant women with advanced maternal age,and therefore ameliorates the pregnancy outcome.