AIM To study the influence of indapamide(Ind) on pharmacokinetics of telmisartan(Tel) and observe the difference between male and female rats. METHODS Wistar rats were divided into Tel and Tel+Ind groups, each group containing 8 female and 8 male rats, and were ig administered a single dose of either Tel 3.6 mg·kg-1 or Tel 3.6 mg·kg-1+Ind 0.135 mg·kg-1, respectively. Blood samples were collected at intervals over 96 h after administration. The Tel concentrations in plasma were determined by high performance liquid chromatography with fluorescence detector. The Tel concentration-time curves were simulated by 3p97 software and the pharmacokinetic parameters were calculated. RESULTS Whatever in female or male rats, there were no significant differences in the main pharmacokinetic parameters of Tel between Tel and Tel+Ind groups. However, females had higher values for area under the concentration-time curve and maximum plasma concentration than males, but lower values for total clearance in both Tel and Tel+Ind groups. CONCLUSION Ind has no significant influences on the pharmacokinetics of Tel. However, pharmacokinetics of Tel is significant different between male and female rats.

OBJECTIVE:To evaluate and compare the efficacy and safety between the chronomodulated chemotherapy of oxaliplatin combined with calcium folinate and tegafur and the normal chemotherapy in the treatment of advanced gastrointestinal cancer.METHODS:A total of 63 patients with advanced gastrointestinal cancer were randomly divided into two grou_ ps:31 in chronomodulated chemotherapy regimen group were assigned to receive oxaliplatin in combination with calcium folinate and tegafur,and another 32 in normal chemotherapy regimen group to receive oxaliplatin combined with calcium folinate and fluorouracil.2 courses of treatment later(21 days/course of treatment)the short-term effects and the adverse drug reactions(ADRs)of the 2 groups were evaluated.RESULTS:The effective rates of the chronomodulated chemotherapy group and the normal group were 77.4%and 43.8%(P