OBJECTIVE:To carry out drug risk management so as to ensurethe safety of clinical drug use in the hospital. METHODS:The mode of drug risk management of our hospital was established,in the form of drug risk identification,risk evalu-ation,risk control and risk review,and the measures for risk management were developed and taken. The effect of drug risk man-agement was evaluated after 3 years (2012-2014) of colletion and analysis of the questionnaires given to clinical medical workers and patients and the results of evaluation by the group of pharmacy management and quality control for drug use in the hospital. RE-SULTS:Following the establishment and improvement of drug management information system,the strengthening of the manage-ment of special drugs,strict implementation of the Management System for the Return and Recall of Drugs,the establishment of specialized drug safety monitoring body,the development and implementation of the measures such as self-inspection in the hospi-tal,the problems about drug safety in our hospital had been decreasing from 2012 to 2014(88,42 and 19 cases respectively);and 96.59%,97.62% and 100% of drug safety problems were solved by the pharmacy staff to the satisfaction of the group of pharma-cy management and quality control for drug use in the hospital respectively in the three years. CONCLUSIONS:The mode of drug risk management established in our hospital has promoted the safety of drug use.

Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels, distributing in a variety of tissues, especially in excitable cells such as heart cells and many kinds of neurons, have an important role in the modulation of heart rate and neuronal excitability. Different from typical voltage-gated sodium channels and potassium channels, HCN channels were evoked inward currents when the cell was hyperpolarized. More and more recent studies have disclosed that HCN channels play important roles in the nervous system, which were linked with its special electrophysiological features as well as its regulatory effect on the cellular membrane excitability. HCN channels could be modulated by many factors including both extracellular molecules and intracellular signaling cascades, which made its functions complicated in the different condition. Based on its role, HCN channels are presumed to be a promising target for chronic pain and brain disorders. In this paper, we will focus on the advancement of roles of HCN channels in the neural system as well as its complex modulator factors.
Cyclic Nucleotide-Gated Cation Channels ; physiology ; Humans ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ; physiology ; Membrane Potentials ; Neurons ; physiology ; Potassium Channels ; physiology

Adult ; Aged ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Recurrence ; Retinal Detachment ; etiology ; surgery ; Silicone Oils ; therapeutic use

Objective To study pre-thrombosis state in patients with cor pulmonale and analyze the value of treatment with low molecular heparin (LMH). Method 46 patients with cor pulmonale were divided into LMH group and routine one. Von Willebrand factor (vWF), prethrombin F 1+2 fragment (F 1+2 ), Fibrinogen (Fg), granule membrane protein (GMP-140) and D-dimer fragment (DD) were detected separately.Result The concentrations of WF,F 1+2 ,Fg,GMP-140 and DD in the patients with cor pulmonale were significantly higher than control. In LMH group, these variables and PaCO 2 decreased and PaO 2 increased markedly after treatment. In routine group, these blood-gas index slightly improved, but no decrease were observed in coagulation variables. Conclusion Early detection and diagnosis of pre-thrombosis state in patients with cor polmanate and timely treatment with LMH can be beneficial to these patients during acute state.

On the basis of the research on the work of subject librarian,this article describes the concrete conceive about constructing the key discipline information service platform in universities,analyzing the practical significance,the practical value and the problems to be dissolved in discipline construction.

Objective To observe the clinical short-and long-term curative effect of the surgical treatment of female stress urinary incontinence (SUI) with tension-free vaginal tape-obturator (TVT-O) treatment,and discuss the safety of the operation and postoperative quality of life.Methods The data were collected from 130 patients with SUI who were underwent TVT-O treatment.The patients'perioperative period,follow-up of postoperative complications,and comparison of the quality of life before and after surgery were analyzed retrospectively.Results A total of 130 patients was successfully completed their surgeries with a mean operative time (47.01 ± 18.82)min,average blood loss (64.38 ±99.62)ml,mean catheterization (2.67 ±0.90)d,and the average length of stay (4.73 ±2.14)d.A total of 101 cases was completed the postoperative follow-up with (a) preoperative quality of life in patients with ⅡQ-7 score 6 to 21 points and an average of (15.74 ± 3.87) min,(b) symptoms of lower urinary tract UDI-6 score of 3 to 22 minutes and the average (10.51 ± 3.70) min,(c) postoperative quality of life improved significantly ⅡQ-7 score from 0 to 21 points and an average of (1.59 ±4.37)points,and (e) UDI-6 score 0 to 14 points and an average of (1.63 ± 2.66)points.A total of 73 patients (72.3％) had the postoperative urinary incontinence,which subjective symptom were completely cured,significant improvement was 11 cases (10.9％),ineffectiveness was 6 cases (5.9％),pad using was 13 patients (12.9％),vaginal mesh exposure and erosion was 2 patients(2.0％),the sexual life postoperatively was affected in 8 patients (7.9％).Conclusions TVT-O treatment of SUI is not only easy to operate but also has clinically high security,few complications,low recurrence rate,and significantly improved patients' living quantities.However,patch compli cations can not be ignored and need further discussion.

ObjectiveTo assess the value of comfortable and maximum walking speed of outcome measuring for locomotion recovery after stroke.Methods10m walking speed of 32 stroke subjects who were able to walk independently were tested in the freely chosen and maximum. The motor function of the paretic lower limb and balance were evaluated with the Fugl-Meyer Assessment,Berg Balance Scale and ambulatory item of Functional Independence Measure. The level of association between gait speeds and the clinical variables were examined with Pearson's correlation coefficients.ResultsComfortable walking speed were significantly positively related to maximum walking speed(r=0.953,P<0.001),and balance, motor function of the lower limb and ambulatory function were significantly positively related to comfortable and maximum walking speed(r=0.742-0.834,P<0.001).The relationship between comfortable walking speed and clinical variables was higher(r=0.787-0.834,P<0.001).Conclusions Both comfortable and maximum walking speed can reflect locomotion recovery after stroke, but comfortable walking speed is more pragmatic,securer and more sensitive.

ObjectiveTo explore the early diagnosis of Alzheimer's disease (AD),the arithmetic calculation ability in the patients with mild cognitive impairment (MCI) was detected under the functional magnetic resonance imaging (fMRI),combined with the neuropsychological test.Methods8 patients with MCI and 9 controls matched for the age, gender, level of education and handedness performed the subtraction of two digits presented visually while the MR machine was scanning. The raw data of the fMRI were processed with the software AFNI. The reaction time and correct ratio were analyzed with the statistical software Excel.ResultsCompared with the controls, the patients manifested longer reaction time and lower correct ratio. The patients' brain activation showed significant decrease in the inferior frontal lobe,temporal neocortex and inferior parietal area mainly in the left hemisphere. On the contrary, the activation intensity and extension in the right inferior frontal lobe were increased as compensation.ConclusionsThe patients with MCI have the deficit in calculation ability. The examination of the calculation by means of the cognitive neuropsychology and fMRI test can offer a powerful reference for the early diagnosis of AD.

ObjectiveTo analyse the most important clinical variables determining walking speed in hemiparetic stroke patients.MethodsThirty-two stroke subjects were able to walk independently in the study.The freely chosen speed was determined by using 10m walking speed test.The motor function,strength of the paretic lower limb,and the balance were evaluated with the Fugl-Meyer Assessment, Motricity Index,and Berg Balance Scale.Modified Ashworth Scale was used to assess the muscle tone of the plantarflexors.The level of association between walking speed and the clinical variables were examined with Pearson's correlation coefficients and by multiple linear regression analysis by using the stepwise method.ResultsThe motor function,strength of the lower limb and the balance were significantly positive related to walking speed(r=0.781-0.834,P<0.001),and the muscle tone of the plantarflexor was moderate negative related to walking speed(r=-0.461,P<0.05).The regression analysis selected motor function of the lower limb as a significant variable(R2=0.696,P<0.001).ConclusionsThe motor function of the lower limb is the important clinical factor to determine the walking speed of stroke subjects.

BACKGROUND: Patients with Alzheimer disease (AD) usually have visuospatial dysfunction at an early stage and most patients with AD were evolved from mild cognitive impairment (MCI).OBJECTIVE: To detect whether a patient with MCI has a visuospatial dysfunction similar to AD. To compare the cerebral activation with ferromagnetic resonance between the healthy people and the patients with mild cognitive disorder.DESIGN: A case controlled observationSETTING: The Department of Neurology of the First Hospital of Peking University.PARTICIPANTS: Nine inpatients with mild cognitive disorder hospitalized at the Department of Neurology of the First Hospital of Peking University from April 2000 to March 2003 were involved and other 9 healthy people matching in age, gender and the educational level were also involved.METHODS: The subjects had the task of discriminating the different finger positions on the clockface. They could see the mission clearly showed on the cloth through refractor, and they were supposed to give the corresponding reaction to different cognitive tasks with left and right hands pressing the keys according to visual sign generated by the computer.Block design was adopted in the cognitive task. Stimulus block and baseline block appeared in turn. Baseline block displayed "+" mapped in the center of the image and was kept for 21s. Stimulus block displayed 10 pictures successively. The finger position of the two clockfaces among three clockfaces was the same in one picture. The absolute value of the rotated angles of the different clockfaces in each image on the same stimulus block was the same. The angles formed by six stimulus block fingers arranged randomly were 300, 450, 1800. The two clockfaces had the same finger positions, and the subjects were requested to discriminate the finger position of these two clockfaces. It was carried out on a 1.5 T GEMRTWIN magnetic resonance scanning apparatus. Then t test was performed to work out the right reaction time and proper rate with Excel software between the patients with mild Alzheimer's disease and the healthy persons. Pretreatment and statistical analyses were performed with analysis of functional neuroimages software used internationally.MAIN OUTCOME MEASURES: Comparison of the reaction time and proper rate between the two groups.parison of the reaction time between the two groups: The reaction time for distinguishing the change of 300, 450, 1800 was longer than that in the control group, and there was significant difference in distinguishing the change of 300, 450, 1800 for the patients [(1 776.7±570.2), (1 646.3±432.7)ms;of the proper rate between the two groups: The proper rate for distinguishing the change of 300, 450, 1800 was significantly lower than that in the control group (62.8±21.4)%, (82.8±15.8)% ;(76.7±17.0)%, (95.0±8.7)%; (69.4vation: the activation density at the bilateral parietal lobe, bilateral temporooccipital borderline and bilateral lateral striate cortex in patients was weaker than that in the control group (P ＜ 0.05).CONCLUSION: Neural network activation related with visual space in patients with MCI was weaker than that in the healthy people indicating that visuospatial impairment exists in the patients with mild cognitive impairment.