Contrast induced nephropathy is an important complication arising from use of iodinated contrast media.Such iatrogenic complication may result in poor prognosis and additional health care costs.Cases of contrast induced nephropathy are on the rise along with the-increasing number of contrast-requiring procedures.Contrast induced nephropathy has been a subject of concern to cardiologists in recent years.Several large series have shown no approved methods for management of periprocedural contrast induced nephropathy.However,identification of high-risk patients,improvement and rectification of related risk factors,use of iodinated contrast media with less renal toxicity,and sufficient hydration may reduce the incidence of contrast induced nephropathy.

Aortic dissection (AD) is a kind of critical macroangiopathy with extremely high mortality ,and it has at-tracted domestic and foreign scholars to research animal AD model establishment .The present article made an over-view on research progress in animal AD model establishment .

Hypertrophic cardiomyopathy (HCM) is featured by asymmetry myocardial hypertrophy ,mainly involves interventricular septum ,and its clinical manifestations are left ventricular dysfunction and arrhythmia .It′s thera-peutic methods include medication ,intervention ,surgery ,dual chamber pacemaker (DDD) treatment and implant-able cardioverter /defibrillator (ICD) treatment etc .This article made following overview on treatment progress of HCM .

Objective To evaluate in-hospital and mid-term results of endovascular type B aortic dissection by stent graft.Methods From May 2002 to September 2006, 46 patients with type B aortic dissection underwent stent graft implantation. The study included 36 men and 10 women with mean age of 62?18 years old. Twenty one patients underwent stent-graft implantation in the acute phase and the other 25 patients in the chronic phase. All patients were followed up for 1 to 52 months (average 17?16 months) and the clinical data of the patients were analyzed. Results No patients died during hospitalization and within 30 days after operation. Transient post-implantation syndrome occurred in 11 patients. Left subclavian artery was totally occluded in 2 patients. Endoleak occurred in 5 patients and in 4 of them the leak closed spontaneously after three months of follow-up. Late endoleak occurred in 1 patient after one year. One patient developed paraplegia at 6 months after the operation. The follow-up CT scan at 3 months documented occlusion of the intimal tear by the stent-grafts and complete thrombosis of the false lumen in all patients. The true lumen of the aorta was enlarged and there was no evidence of migration or twisting of the stent-grafts. Ascending aortic dissection occurred in 1 patient after one year. Three patients died within the follow-up period. The mortality during the follow-up period was 6.7%. The actuarial survival curve by the Kaplan-Meier method showed a 4-year survival rate was 89.3%. Conclusion In-hospital and mid-term results showed that endovascular repair was effective in the treatment of type B aortic dissection.

Objective To evaluate the effectiveness and safety of successive interventional treatment in patients with thoracic aortic dissection and coronary heart disease by endovascular graft exclusion(EVGE)and percutaneous coronary intervention(PCI)respectively.Methods From January,2005 to July,2007,8 patients with Stanford B aortic dissection and coronary heart disease received successive EVGE and PCI in our centre.All patients were performed with EVGE 3-7 days prior to their PCI.Results The site of dissection tears were confirmed by aortic angiography which located within 0~10 mm from the exterior margin of left subclavian artery in 1 patient,11-30 mm in 4 patients and 31-50 mm in 3 patients.One patient had two tear gaps.Dissection of or distal to the renal arteries were involved in 7 patients.Talent graft(Medtronic Corporation,U.S.)was used in one patient and Aegis grafts(Microsport Medical Corporation,China)in 7 patients.Eight trunk tectorial membrane stents were used with lengths ranged from 100 to 140 mm with diameters ranged from 34 to 38 mm.Left subclavian artery was thoroughly covered by the proximal section of the graft in one patient,which resulted in a weak left radial artery pulse but with no obvious ischemic symptom of the left upper limb and brain.Procedures were technically successful in all patients and no severe complication such as death,paraplegia,and kidney insufficiency occurred after the procedure during hospitalization.Post-procedural aortography showed no leakage in 4 patients and minor leakage in 4 patients.Two patients had residual thoracic back pain which could be relieved by drugs.Coronary angiography showed that 4 patients had single-vessel disease,2 had double-vessel disease and one had triple-vessel disease.The mean stenosis rate of the target lesions was 85.6%?14.0% and the mean diameter of the reference vessels was 2.8?0.3 mm.Twelve stents were inplanted in 11 target vessels in 8 patients.The mean length of stents was 23.5?13.6 mm.The procedural success rate of PCI was 100% and no severe complication occurred.No mortality,delayed endo-leak,adverse cardiac events and repeat intervention was recorded during a mean follow-up period of 18.0?8.5 months.Conclusion It is safe and feasible to treat Stanford B aortic dissection and coronary heart disease by successive inter vention of EVGE and PCI.The effect of anticoapulation therapy after PCI on EVGE still requires further investigation.

Objective To explore the in-hospital clinical results of percutaneous coronary intervention (PCI) in patients with multi-vessel coronary disease during past 11 years. Methods Data related to rates of success, complications and clinical effects of 4 365 patients who were hospitalized in our center and underwent PCI for their target multi-coronary arteries from 1995 to 2005 were analyzed. Among them 3 833 patients had acute coronary syndrome (ACS, 87.8%), among whom 1 480 suffered form acute myocardial infarction within 30 days (38.6%), 2 353 unstable angina pectoris (61.4%), and the remaining 532 patients had stable angina pectoris (12.2%). Results Overall success rate of PCI procedure for all patients and target lesions were 96.9% ( 4 230/ 4 365) and 98.8% ( 11 185/ 11 320), respectively. The total in-hospital all-reason mortality was 1.3% (56/ 4 365) and the mortality during PCI procedure was 0.05 % (2/ 4 365).The complication rate related to PCI procedure was 7.2% (314/ 4 365). After PCI procedure the angina-free survival rate for all patients was 96.2% ( 4 147/ 4 309) at discharge and the average hospital stay was 13?9 days. Conclusion The success rate of PCI procedure in patients with multi-vessel coronary disease is high, and the rates of complications and in-hospital mortality are low, all indicating that with PCI therapy an ideal short-term effect in patients with multi-vessel coronary disease can be achieved.

Objective To compare the one-year outcome between complete and incomplete revascularization by percutaneous coronary intervention (PCI) in patients with multivessel coronary disease. Methods From June 1995 to September 2004, a total of 2579 patients with multivessel coronary disease were treated by PCI in our centre, among them 2278 patients (88.3%) achieved complete revascularization (CR group) and 301 patients achieved incomplete revascularization (IR group). One-year outcome was compared between the two groups. Results The rates of triple vessel disease, complex type B2/C lesions, chronic total occlusion were significantly higher in IR group than those in CR group, and the target vessel stenostic degree before PCI was also more severe in IR group. The PCI success rates in CR group and IR group were 96.4% and 94.0% (P0.05). The rates of angina recurrence and major adverse cardiac events (MACE) were significantly lower in CR group patients compared with the patients in IR group (5.7% vs 9.2%, P

Objective To assess the significance of high-density lipoprotein cholesterol(HDL-C) levels in patients with non-ST-elevation acute coronary syndrome(NSTE-ACS) undergoing percutaneous coronary intervention(PCI).Methods In a group of 409 patients with NSTE-ACS undergoing PCI admitted during January 2006 to January 2007,220 patients had HDL-C≥40 mg/dL(normal HDL-C group) and the remaining 189 had HDL-C

Objective To explore clinical feature and coronary artery lesion characteristics of non-ST-segment elevation myocardial infarction (NSTEMI).Methods Seventy-three patients of NSTEMI were studied,their clinical data and results of coronary angiography being analyzed.Results Risk factors of coronary artery disease among all the patients were 50(68%) with hypertension,26(35%) with diabetes,34(46%) with hyperlipidemia and 28(38%) with smoking history.There were 52(71%)with angina pectoris before this hospitalization,22(30.6%) with inhospatial angina pectoris,15(20.4%) with severe arrythmias,7(10.2%) with cardiac shock,3(4%) died.52(71%) were with ST-T depression and 21(29%) with normal ECG.Coronary angiography revealed 54(74%) with lesions in more than one vessel and 19(26%) in one vessel (P

OBJECTIVE:To establish the quality standard of Welie capsule METHO DS :Fritillary bulb,rhizoma corydalis and magnolia bark in the capsule were ident ified with TLC;the contents of berberine hydrochloride was determined with TLC scanning RESULTS:Fritillary bulb,magnolia bark and rhizoma corydalis could be tested out in TLC chromatogram;berberine hydrochloride appeared good linear re lationship in the range of 0 1～1 0?g,r=0 9 991;and the average recovery w as 97 84%,RSD=2 86%(n=5) CONCLUSION:This method can be used to control the quality of Weile capsule