In order to explore the implement of English for academic purposes (EAP) teaching,the selective course of English for international academic conference was opened up in the Third Military Medical University.The teaching practice was enacted based on 50 selected medical undergraduates,with the feature of modularized teaching,experimental study and teaching team.Teaching outcome was assessed by means of students' record,investigation questionnaire,teaching video and teachers' journal,which indicated that the course of English for international academic conference played the positive role in promoting student's ability for EAP and the key questions included how to make it interesting while keeping it professional and the quality of teachers.

Hepatitis B virus (HBV) infection is a global public health issue,especially in the Asian-Pacific region.At present,entecavir,tenofovir,and pegylated interferon are the first-line antiviral drugs recommended by related guidelines for the prevention and treatment of hepatitis B;however,different national/regional policies,economic level,coverage of health insurance,and medical level have caused the difference in antiviral regimens.Therefore,we have established a long-term follow-up cohort of hepatitis B to evaluate the efficacy of different treatment regimens,in order to improve the cure rate of hepatitis B and reduce the incidence rates of liver cirrhosis,liver cancer,and end-stage liver disease.Real-world data from cohort study help to understand the differences between guidelines and clinical practice,provide a reference for HBV guidelines,and balance clinical effect and cost-effectiveness.

Colon carcinoma is one of the most common malignant neoplasms.The incidence of this disease has been increasing significantly in recent years in China.Ahhough diagnostic and therapeutic methods have been im proved greatly.carcinoma invasion and metastasis are considered to be the main causes of poor prognosis and death. Tumor metastasis is a complicated process with multiple steps and factors.Cell adhesion molecule(CAM)play a very impntant role in this process while it expresses exceptionally or loses its function.CAM is a kind of glycopro tein molecule by the cell synthesis which mediates the intereontact and intercombination between cell and cell or be tween cell and matrix.It takes part in a series of important physiologic and pathologic processes,such as cell signal conduction and activation,cell extension and migration,tumor metastasis and wound healing,and so on.

Objectives:To observe the effect of intrahepatic cholestasis on the development and growth of fetus in pregnant rats. Methods: The animal models of intrahepatic cholestasis were made by injecting benzogynestryl (5 mg/kg body weight) or cholate (2.4 mg/kg body weight) for 5 days starting from 16th day of pregnancy. Biochemical parameters of fetal plasma and amniocent were determined at the 21st day of pregnancy. The pathological lesion of placenta in rats was also observed. Results: Cholic acid group showed lower body weight and high level of estrodiol in fetal plasma with high metaphase mortality of fetus. The level of TBA in amniocent was high in estrodiol group compared with normal control group. Pathologically, placenta edema and chorion denaturalization and necrosis with infiltration of neutrocyte were observed in both groups. Conclusions: Intrahepatic cholestasis is detrimental to the development and growth of fetal rats in pregnancy rats.

OBJECTIVE:To analyse the current situation and developing trend of consumption of cardiovascular drugs in Nanjing district,so as to provide information for the research,production,sale and application of these drugs METHODS:According to the order of sum of money,the purchasing information of the drugs used for cardiovascular diseases in 19 hospitals in Nanjing district between 1997～2001 were analysed RESULTS:The sum of money of the drugs used for cardiovascular diseases in 19 hopsitals in Nanjing district was increased more than twice in 5 years,and the consumption of anti-anginal and vasodilating agents,antithrombotic agents and antihypertensives occupied first three places in the category all the time In recent three years,calcium antagonists have occupied the front three places in the category CONCLUSION:With the increase of old age people's proportion in our country,the market requirement is enormous and the prospects for exploitation are capacious for the drugs used for cardiovascular diseases

Objective To investigate the prevalence of anemia in patients with rheumatoid arthritis (RA) and the relationship between anemia and disease activity of RA. Methods Retrospectively analyze the data of 239 RA patients. Results (1)Estimates of the prevalence of the anemia was 51.4% ;the level of anemia was mild and moderate,and none was severe. (2)There were statistic differences between the patients with anemia and without anemia in disease duration,morning stiff ness,ESR,CRP and degree of X-ray change. (3)There were statistic differences between the patients with anemia and without anemia in leukocyte counts and platelet counts. (4)The level of hemoglobin (Hb) was significantly increased after anti-rheumatoid treatment. Conclusion (1)Anemia is a common sign in individuals with rheumatoid arthritis. The level of anemia is mild and moderate. (2)There are important associations between anemia and disease activity of RA. (3)The level of hemoglobin is increased after anti-rheumatoid treatment.

Objective:To evaluate the significance of the combination of rheumatoid factor (RF) and anti-filaggrin antibodies (AFAs) in the diagnosis of rheumatoid arthritis (RA). Methods:Sera from 266 RA patients and 186 controls were studied. RF and some kinds of AFAs (including antikeratin antibodies, anti-perinuclear factor and anticyclic citrullinated peptide antibodies) were detected using immunofluorescence and ELISA respectively. The distributions of these antibodies were compared to determine the significance of the combination of RF and AFAs. Results:The sensitivity and secificity of RF for the diagnosis of RA were 65.8% and 81.8% respectively, as compared with those of anti-CCP or RF positive were 86.5% and 80.6% respectively. Only a slight change was found in the secificity and negative predictive value between them. RF could not be detected in 91 patients while 64.8% of them could be found to have at least one kind of AFAs. Conclusion:AFAs, particular anticyclic citrullinated peptide antibodies, could be helpful for the diagnosis of RA especially in RF-negative patients.

Objective To describe the health literacy level and to explore the effect of health literacy level on education retention of patients with stroke.Methods Totally 100 stroke survivors were selected as the subject by convenience sampling.They were evaluated by Short Test of Functional Health Literacy in Adults on admission,and they accepted 60-90 minutes education intervention during hospitalization.Evaluation retention were measured before discharge.Results The score of the overall health literacy was (15.60±1.36) points,among of them,low level was 37 cases,general level was 24 cases,high level was 39 cases.Age,education level and Mini-Mental Status Exam score had a significant effect on the health literacy of patients with stroke (x2/F=14.248,12.082,11.329,P＜ 0.05).After education intervention,the score of education retention was (6.69±2.00)points,and the score of education retention in low,general,high level health literacy were (5.08±2.06),(7.46±1.61),(7.51± 1.76) points,and there were significant differences(F=14.223,P ＜ 0.05).Heahh literacy had a effect on education(P ＜ 0.01).Conclusions The level of health literacy of stroke patients has the effect of improving the education retention.Improving and maintaining the health literacy of stroke patients should be the development direction of the prevention and treatment of stroke diseases.

Objective To evaluate the diagnostic specificity and sensitivity of anti-p68 antibody in rheumatoid arthritis (RA), and to analyze the relationship between anti-p68 antibody and the activity of RA . Methods Anti-p68 antibody was tested in the serum of 183 RA patients and 195 controls by indirect immunofluorescence (IIF). The clinical characteristics of RA between anti-p68 positive group and negative group were compared. Results ① The positive rate of anti-p68 antibody was 67.8% (124/183) in RA, 14.9% (17/114) in other rheumatic diseases and none in normal controls (0/81). Anti-p68 antibody was different from other auto-antibodies found in RA. ② Its sensitivity was 67.8% and specificity was 91.3% for RA, positive prediction rate was 87.9% and negative prediction rate was 75.1%. ③ There was statistic difference between the positive group and negative group in disease duration, RF and degree of X-ray changes. Conclusion ① Anti-p68 antibody is a new and specific serum maker for diagnosis of RA. ② The antibody is correlated with disease duration, RF and X-ray changes.

Interstitial cells of Cajal (ICC) is interposed between enteric neurons and smooth muscle cells in gastrointestinal muscles, it is the pacemaker cells of the gastrointestinal tract. ICC are essential for generation and regeneration of slow wave and play an important role in the regulation of gastrointestinal smooth muscle. Further study of ICC has importance in realizing the physiology of gastrointestinal motor and the mechanisms of gastrointestinal motility disease.