The patients of chronic lymphocytic leukemia(CLL)have great individual differences.It is important for clinicians to determine the prognosis at the beginning of diagnosis and choose proper treatment for the patients.The recent advances in biological prognostic indicators of CLL were reviewed,including IgVH gene mutation status,ZAP70,CD_(38),chromosome abnormality[t(11q;v),del(11q),del(17p),+12 and del(13q)].telomere and telomerase.

Objective:To evaluate the effects of the intervention of cognitive-behavioral group counseling for elderly hypertensive patients with anxiety symptoms.Methods:The Screen for Self-Rating Anxiety Scale (SAS) of higher scores ≥41 was used to screen out 80 elderly hypertensive patients with anxiety symptoms,who were randomly signed to the intervention group (n =40) and the control group (n =40).The intervention group was given cognitive-behavioral group counseling for 8 weeks,while the control group without any intervention.All participants were assessed with the State-Trait Anxiety Inventory (STAI),Simplified Coping Style Questionnaire (SCSQ),UCLA Loneliness Scale and Self-Esteem Scale (SES) at base line,8 weeks after the intervention and one month after the end of intervention.Results:Thirty-seven elderly hypertensive patients of the intervention group completed the 8-week sessions and 32 elderly hypertensive patients participated in the l-mouth follow-up.Thirty-nine participants of the control group completed the 8-week wait and post 8-week wait follow-up diagnostic tests.Compared to baseline,the patients had significant reduction in the scores at SAI and negative coping style after treatment (Ps ＜ 0.01),whereas the scores of those in the control group did not show any significant reduction (Ps ＞0.05).In the comparison of before-post difference between intervention and control group,the difference of SAI scores and negative coping style scores were higher inintervention group than in control group (Ps ＜ 0.05).The 1-month follow-up showed that the scores of SAIand negative coping style decrease continuously (Ps ＜ 0.01).Contusion:It suggests that cognitive-behavioral group counseling could reduce the level of anxiety in the elderly hypertensive patients.

Migraine is a kind of nerve vascular disease, characterized by hemialgia, moderate and severe, pulsating pain. Acupuncture as a safe and effective analgesic therapy, has been widely used in more than 160 countries and regions around the globe. Treating migraine with acupuncture has certain good features as effective, non-toxic side effects and untoward effect.But its mechanism is still not very clear.The cerebral blood flow study ( CBF study) is currently the most credibility of migraine pathogenesis theory.Now based on the theory of CBF study, this paper discusses the acupuncture treatment of migraine which can provide the basis for clinical treats.

To investigate the protective effects of Tangxinping Capsule, a compound traditional Chinese herbal medicine, on diabetic cardiomyopathy in rats.

Objective To explore the effect of health education path on rehabilitation training of patients with total knee arthroplasty (TKA).Methods One hundred and eighty TKA patients were divided into experiment group and control group equally according to the sequence of admission.In the control group routine rehabilitation training was adopted,while in the experiment group the training was done on the instruction of health education path.The two groups were compared in terms of training accuracy,scores on health education, satisfaction with nursing and training efficiency after 12 months.Result Training accuracy,scores on health education,satisfaction with nursing and training efficiency after 12 months of the experiment group were significantly higher than those of control group(all P<0.05).Conclusion The application of health education path in rehabilitation training of TKA patients can improve the training efficiency and is good for patients’recovery.

Objective To study the relationship between Kazakh hypertensive patients with blood uric acid ,lipid levels and psy-chological factors .Methods 90 Kazak patients with hypertension in our hospital from January to August 2012 were randomly se-lected as the hypertension group and contemporaneous 171 non-hypertension patients as the healthy control group .Blood uric acid (UA) ,triglycerides(TG) ,total cholesterol(TC) ,low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein choles-terol(HDL-C) were detected and the perceived stress scale(PSS) was adopted to assess the mental status .Results The mean val-ues of TG ,TC ,HDL and LDL in males of the hypertension group and the mean values of UA ,TG and LDL in females of the hyper-tension group were significantly higher than those in the normal control group after adjusting age and BMI (P<0 .05);in the hyper-tension group ,UA was positively correlated with TC (r=0 .221 ,P<0 .05) .The level of perceived stress was positively correlated TC and LDL(r=0 .473 ,P<0 .05;r=0 .321 ,P<0 .05) and negatively correlated with TG and HDL (r= -0 .461 ,P<0 .05;r= -0 .412 ,P<0 .05) after adjusting age ,sex and BMI .Conclusion The blood lipid level in Kazakh hypertensive patients has certain correlation with the perceived stress .

It has long been one significant focus in the field of surgery to reduce postoperative incisional complications.Recently,incisional negative pressure wound therapy (iNPWT),which was designed to reduce the incidence of incisional complications,has gradually been applied for primary incision closure.This article reviews the relevant basic and clinical studies to elucidate the mechanism of iNPWT and its clinical safety and efficacy,and answers some fundamental questions regarding clinical application of iNPWT.

Objective To determine the effect of angiotensin( 1 -7) [Ang( 1 -7) ]on the left ventricular hypertrophy and myocardial fibrosis in a pressure-overload hypertensive models,infra-nephric aorta coarctation ( INAC) ,and a renin-angiotensin-aldosterone system ( RAAS) activation hypertensive model,two kidney one clip ( 2K1C) in the early and late stage. Methods Totally 120 health male Wistar rats were randomly and equally divided into 6 groups,that is,sham INAC group,INAC group,INAC Ang( 1 - 7) group,sham 2K1C group,2K1C group and 2K1C Ang( 1 -7) group. INAC and 2K1C hypertensive models was established to cor- responding groups and osmotic minipump implantation was carried out to the rats to deliver the Ang( 1 - 7) to their body homogenously and to examine the parameters representing the blood pressure,including left ventricu- lar hypertrophy ( LVW,LVI,CA) and myocardial fibrosis ( CVF and PVCA) . Results Left ventricular hy- pertrophy ( LVH) was observed in the early stage and developed in the late stage both in the 2K1C and INAC groups. Ang( 1 -7) decreased LVW,LVI,CA both in the early and late stage in the 2K1C model( P 0. 05) . Myocardial fibrosis happened and developed progressively in the 2K1C hypertensive model ( P 0. 05) . There was a mild myocardial fibrosis happened in the left ventricle of the INAC model in the late stage( P

OBJECTIVE To discuss the diagnosis and treatment of Burkholderia cepacia(BCE) pneumonia. METHODS The 31 cases of inpatients and outpatients in our hospital were analyzed from Jul 2005 to Dec 2007. RESULTS From them 11 cases were with community-acquired pneumonia and 20 cases with hospital-acquired pneumonia,the underlying diseases in 27 cases.Of these cases,19 cases were kidney transplant recipients,four cases with chronic obstructive pulmonary disease,seven cases with non-insulin dependent diabetes,three cases with cerebral vascular diseases,and two cases were with malignant tumors.All cases were diagnosed by bronchoscopy,bronchial lavage,and BCE positive in douche liquid.At last there were 24(77.4%) cases cured,2 cases discharged(6.5%) and 5 cases deceased(16.1%). CONCLUSIONS BCE is a multi-drug resistant bacteria.BCE pneumonia often appears severe.It appears non-specific clinical symptoms in early stage and higher mortality.It should be treated as soon as possible by using piperacillin /tazobactam-based combined anti-infection treatment.

ObjectiveTo study the intelligence quotient(IQ) profile of the children with idiopathic generalized tonic-clonic seizure (GTCS) and the factors influencing IQ of them.MethodsAll 28 children with GTCS were selected who were aged 9 ～ 16 years in 20 GTCS families in a mountain area of the south of Anhui Province,all available healthy siblings of the children included in the epilepsy group,did not have epilepsy,and were nearest in age to the children with GTCS ( control group 1 ),and thirty children aged 9 ～ 16 years old who had lived in the same village ( control group 2) entered into our study.The IQ was studied of the three groups of children and the factors influencing IQ of children with GTCS at the same time.The data were input SPSS12.0 and analyzed.ResultsThe IQ of children with GTCS(85.64 ±20.57)was lower than that control group 1( 103.39 ± 11.17)and the control group 2 ( 106.17 ± 11.67).The difference between children with GTCS and the two control groups were significant for almost all the subtest quotients except completion of drawing and picture arrangement.No significant differences were found between the control group 1 and the control group 2 on the IQ and the subtest quotients.IQ scores of children with GTCS showed significant linear correlation with father's education( r=0.453,P＜0.01 ),age at onset of epilepsy( r=0.506,P＜0.01 ),duration of seizure disorder( r=-0.533,P＜0.0l ),status epilepticus( r=-0.732,P＜0.01),total number of seizures( r=-0.761,P＜0.01) and seizure frequency ( r=-0.708,P ＜ 0.01 ).ConclusionThe IQ scores of the children with idiopathic GTCS are lower significantly than general children population.Epilepsy-related variables affecting IQ scores of the children with idiopathic GTCS are duration of seizure disorder,status epilepticus,age at onset of epilepsy,total number of seizures,seizure frequency.