Having been launched for almost two decades,the seven-year medical educational program in Jiangsu province has cultivated and exported a certain amount of popular high-level medical talents with high and integrated quality for our society.To establish and construct the medical educational hierarchy which takes the five-year program as the principal part while focuses on the eight-year program corresponding to our economic level will be the inevitable tendency for the development of the higher education in our province.

Multiple myeloma (MM) is a malignant hematological disorder caused by the abnormal proliferation of monoclonal plasma cells. Traditional high-throughput cell sequencing reflects the heterogeneity of cell population, while it ignores the genetic information in single-cell. The development of single-cell sequencing has enabled the access to cell-to-cell variation in tumor and microenvironment of bone marrow, providing a deep understanding of the pathogenic mechanisms of MM and guidance for clinical treatment. This paper reviews the latest progress of single-cell sequencing and its application in disease pathogenesis, monitoring of disease progression, immunotherapy and therapeutic responses of MM.

The effect of tumor necrosis factor (TNF) in combination with thymosin and chemotherapy on advanced primary liver cancer was observed. Eighty-nine advanced primary liver cancer cases were randomized into two groups: Patients in the control group were treated only with chemotheraputic drugs, and patients in the observing group were treated with TNF, thymosin and chemotheraputic drugs. The results showed that there were higher primary tumor regression rates and statistically reduced AFP in the observing group than control group. The rate of half year survival, one year survival and two years survival improved 28.6%, 18.0% and 5.1% than those of control group, respectively. We belived that this combined therapy could effectivelly improve the patients immunity, the quality of survival, and long the patients survival period.

Objective To analyze current situation on the quality of statistical data under hospital information system in order to enhance data supervision and improve data quality.Methods The quality of statistical data in the first half year of 2008 was described,and the quality of the dates that dates of clinic service,dates of patients discharged from hospital and surgical dates were analyzed.Results The measures about how to ensure the authenticity and effectiveness of the data were introduced.Conclusion The high practical value is provided by utilizing "No.1 Military Medical Project" Information System of statistical data for manager to provide decision support.

Objective To share the data of Fully Automatic Biochemistry Analyzer SINNOWA -B300 with Hospital Information System (HIS). Methods The main characters and functions of the Data Pipeline of PowerBuilder were analyzed,and designed application program to connect Access Database of analyzer and Oracle Database of HIS. Results The analyzer can input automatically into Oracle Database of HIS. Conclusion The use of PowerBuilder data pipeline object combined with programmer achieves real-time data sharing,the simple and reliable technology can provide a technical reference for the development of LIS of hospitals.

Objective To study the protective effect of different doses of rosiglitazone (RSG)against focal cerebral ischemia-reperfusion injury in rats．Methods Forty male sprague Dawley rats were randomly divided into the following groups：sham-operation，control，lowdose RSG(1 mg/kg·d)，moderate-dose(2 mg/kg·d)，high-dose(4 mg/kg·d)goups(n=8 in each grow)．A rat model of middle cerebral artery occlusion for 2 hours and reperfusion for 22 hours were induced by the intraluminal suture method．An automatie biochemical analyzer was used to detect the blood glucose and lipid levels．A solid phase sandwich enzyme-linked immunosorbent assay was used to determine serum insulin levels，and the insulin sensitivity indexes were calculated．The effect of rosiglitazone on infarct volume and behavioristics was observed．Results Compared with the control group，the infarct volume was significantly reduced，and the neurological function scores were improved significantly in each RSG group(P<0．05 or P<0．01)．The insulin sensitivity was significantly increased(P<0．05 or P<0．01)，and hyperglycemia was reduced significantly after cerebral ischemia(P<0．05)and showed a dose-dependent manner.Conclusions RSG has obvious neuroprotective effect against cerebral ischemia／repeffusion injury in rats．Its mechanism may be associated with the increase of insulin sensitivity．

Objective: To explore the mechanism of Qiangpi Bujing Huayu Yizhi Capsule(QBHYC) in treatment of multi-infarct dementia(MID).Methods: The complex MID model was made by administration of Small Chengqi Decoction and injection of emboli into the internal carotid artery.The dementia rats were randomly divided into 4 groups,the sham operation group,the operation group,the Chinese materia medica group and the western medicine group.The activity of SOD and the content of MDA in the rats' plasma and brain were detected by photochemical methods,and the mechanism of the possible intervention effects of QBHYC was analyzed.Results: The activity of SOD in the Chinese materia medica group was significant increased,while the content of MDA of this group was attenuated,compared with that of the operation group and the western medicine group,it had highly significant difference(P

Objective To explore connotative quality of how to improve the electronic medical records. Methods Combining with the ways of improving connotative quality in fact, the advantages and common defects of electronic medical records were reviewed and some suggests were brought forward. Results The connotative quality of electronic medical records could be enhanced by specific quality standards, the implementation of quality control of section links and the emphasis quality control suited to expert's specialty, at the same time, the connotative quality of electronic medical records was raised by monitor methods of informationazition platform. Conclusion Improving the whole medical level of hospitals is the crux of raising the connotative quality of medical records.

AIM: To investigate the effect of lipopolysaccharide (LPS) priming on macrophage(M?). METHODS: Macrophage cell line RAW264.7 were pretreated with or without LPS for 1 h, then challenged with PMA, or LPS, muramyl dipeptide(MDP), Zymosan, formyl-methionyl-leucyl-phenylalanine(FMLP) for 1 h . O  2 production in supernatants and intracellular free calcium([Ca 2+ ]i ) were measured, and changes in [Ca 2+ ]i and LPS induced O  2 production were compared. RESULTS: LPS pretreatment significantly increased O  2 production in RAW264.7 cells challenged with the stimuli, and in a certain extent, both O  2 production and increase of resting intracellular [Ca 2+ ]i were dose- and time-dependent on LPS pretreatment.Furthermore,the peak [Ca 2+ ]i was significantly higher in LPS pretreated groups than that of LPS unpretreated groups when challenged with PMA. Pretreatment with Ca 2+ inophore A23187 mimicked the LPS priming effects on O  2 production, but pretreatment with Ca 2+ chelator BAPTA and EGTA blocked this priming effect. CONCLUSION: LPS induced M? priming effect on O  2 production is dependent on elevation of resting intracellular [Ca 2+ ]i .

From both doctors and patients′different perspectives , this paper analyses the causes of conflict of doctor-patient communication , and from the subjective and the objective , the history and reality , individual and social aspects of light on the restricting factors for good doctor -patient communication , and puts forward strengthe-ning the consciousness of active , rule execution , achieving full coverage , explore ways to standard mode , rich di-verse ways and other countermeasures .