Vasovagal syncope (VVS) although is a benign disease,repeated syncope attacks can reduce quality of life in patients,in some cases,can also lead to serious body injures.Therefore,it is required and necessary to the treatment of patients with VVS.The treatment of VVS includes health education,drug treatment and non-drug treatment.

Chemotherapy has been the cornerstone of cancer treatment for decades. However, albeit remarkable, the response to chemotherapy is generally short-lived. With deepened understanding of cancer immunology, resurgence was recently witnessed in the field of cancer immunotherapy. Unlike chemotherapy, immunotherapy induces a relatively mild but stable response. Accumulating evi-dence reveals that apart from chemotherapy's direct cytotoxic activity, chemotherapy exerts immune-potentiating effects by increas-ing the immunogenicity of tumor cells or by disrupting the tumor-induced immunosuppression and altering the immune microenviron-ment. The latter mechanism serves as the basis for the combined use of chemotherapy and immunotherapy. In this review, we exam-ine the rationale for combinatorial therapy in accordance with the current understanding on tumor immunity and newly discovered im-mune-based chemotherapeutic mechanisms. We further discuss the available preclinical and clinical studies on the combination of chemotherapy and immunotherapy for cancer treatment. We aim to provide a framework for further research.

OBJECTIVE:To study the pharmacological actions of compound Yinshen granules(CYSG) on cerebral ischemia injuries in rats METHODS:Using an established middle cerebral artery occlusion(MCAO)model devised by Tamura,we observed infarction areas of the brain and behaviour grade of cerebral apoplexy,and calculated brain water content and brain index RESULTS:CYSG(10 0g/kg,5 0g/kg in rats)significantly reduced infarction areas,ameliorated neurological symptoms,decreased brain water content and brain index after MCAO in rats CONCLUSION:CYSG can protect ischemia cerebral injuries in rats

Objective:To study the clinical characteristics of children with paragonimus pericarditis.Methods:The diagnosis and treatment effect of 43 children with paragonimus pericarditis were retrospectively analysed.Results:There was diversity in the clicinal manifestations.Thirty-four cases were treated with praziquantel,pericardiocentesis,open pericardial drainage and so on.In 30 cases that were followed up,26 cases were cured and 4 cases developed pericardial constriction.Four cases with constrictive pericarditis were cured after pericardiectomy.Conclusion:The children with paragonimus pericarditis could be diagnosed early by careful asking of the case history of eating crabs,routine examination of the numbers of the acidophile in blood and pericardial effusion and paragonimus antigen intracutaneous test.It is possible to develop pericardial constriction after clinical cure in those cases that have had a long course of disease before treatment.

A case of the 12-year-old female patient with first relapsed acute lymphoblastic leukemia was reported. During the induction chemotherapy, the patient, transfused with whole blood and granulocytes, developed diarrhea and generalized macular rash. The skin biopsy showed some changes compatible with graft versushost disease (GVHD). Therefore, the related literature was reviewed, and the clinical features of transfusionassociated GVHD and the measures for its prevention and treatment were succinctly introduced.

Objective To investigate the influence of negative emotion on patients with peptic ulcer and their cognition about self-management knowledge. Methods Zung self-rating depression scale (SDS), self-rating anxiety scale(S/IS) and self-designed survey questionnaire of peptic deer patients' gen-end knowledge were used to examine 105 peptic ulcer patients in outpatient and inpatient in the digestive department and the data were compared with those of 106 healthy people. Results The peptic ulcer pa-tients' total score of SDS and SAS, and the occurrence rate of positive symptom were obviously higher than those of healthy people. In the group of ulcer patients, we compared the data of SDS one by one, the emo-tion of patients was different when their profession was different. The difference between patients with and without anxiety in keeping emotion steady and appropriate diet was significant. 45.8%～78.1% of patients with negative emotions didn't understand the cycle of treatment, regular consultation with a doctor or com-plication. Conclusions Nurses should evaluate the emotional state of patients, establish nursing plan based on individual patients, give different nursing and education to different patient. Thus patients' general self-management knowledge and compliance can be improved, their spirit health level can be alleviated. It can also reduce incidence of the disease and prevent relapse.

Lung cancer is the leading cause of cancer death worldwide. Significant advancements have been observed in the thera-py for non-small celllung cancer (NSCLC). With constant extension of new awareness regarding the histopathology of lung cancer, ho-mologous chemotherapeutic regimens have been developed on the basis of histopathological sub-typing methods. With developments in molecular biology, driving gene mutations during tumorigenesis and progression have been discovered. A series of targeted drugs for various molecular subtypes has also been investigated and developed on the basis of these mutations. This review summarizes recently published clinical outcomes on the management of advanced NSCLC and strategies to apply drugs in clinical treatments.

Objective:To analyze data of 5604 cases who received health examination in our hospital ,and understand morbidities of overweight and obesity in these people and their relationship with blood glucose level . Methods :Morning venous blood was taken from the 5604 subjects undergoing health examination to measure blood glucose lev‐el ,and their body weight and height were measured at the same time ,then body mass index (BMI) was calculated and analyzed .Results:Among the 5604 subjects , prevalence rates of overweight and obesity were 42.1% and 13. 3% respectively ,and they were 50% and 16. 4% in men ,and 25. 4% and 6. 8% in women respectively .Among different age groups (except ≥71 years group) , prevalence rate of overweight in men was significantly higher than that of women , P<0.01 all;except ≥61 years subjects , prevalence rate of obesity in men was significantly higher than that of women ,P<0.01 .In overweight group ,risk relative (RR) of impaired fasting blood glucose and dia‐betes mellitus to those of subjects with normal body weight was 2.32 (95% CI 1.91~2.82) and 2.92 (95% CI 2.31~3.70) respectively ;in obesity group , RR of impaired fasting blood glucose and diabetes mellitus to those of subjects with normal body weight was 3.2 (95% CI 2.57~3.99) and 5.17 (95% CI 4.53~5.90) respectively , P=0.001 all . Conclusion:Overweight and obesity have become a common problem among our customer groups .Compared with those with normal body weight ,overweight and obesity greatly increase risk ratio of impaired fasting blood glucose .

Holter monitoring remains an useful diagnostic tool in the evaluation of syncope in children if synco-pe remains unexplained after the initial examination.But it should not be used as a screening tool.Holter monitoring is recommended in children who were suspected as cardiac syncope or who had an abnormal electrocardiogram.For chil-dren with frequent syncope,Holter monitoring is highly recommended.More information can be provided with extended Holter monitoring to 48 hours if possible.Heart rate variability is probably useful in predicting head -up tilt test diagno-sis of neurally mediated syncope.

Due to the advance of CT equipment, combined with the current intensifying doctor-patient conflict, the indication of CT examination is relaxed, even expanded to the examination of benign lesions, which contributes to the blind diagnosis using CT or the so-called“Casting a big net”. However, X-rays bring two kinds of risks. One of them is the risk of the accumulated X-rays, the other one is the missed diagnosis resulting from the poor image quality, which is caused by the low amount of radiation. Therefore, how to strike a balance between these two not only becomes the focus of academic circles, but sparks the whole society’s attention. This article elaborates X-rays hazards, CT radiation does, application of Multiple Detector Spiral CT, purpose and principles of radiological protection and optimization of CT scanning technology. The author believes “exposure does individualization” can be achieved under the principle of ALARA (as low as reasonably achievable), or we can even minimize the exposure does according to the requirements of diagnosis and accept the image with appropriate noise.