1.Negative expression of RECK indicates unfavorable clinical outcome for breast cancer
Shaoqiang CHENG ; Yang LIU ; Xiaoshuan ILANG ; Da PANG ; Guoqiang ZHANG ; Jinsong WANG ; Yanni SONG
Practical Oncology Journal 2014;(1):12-18
Objecive To explore the significance of RECK expression in breast cancer .Methods Im-munohistochemical staining was used to analyze RECK expression levels in patients with breast cancer .We com-pared these data with the clinicopathological features of these patients .Rseults Breast cancer patients with nega-tive RECK expression had significantly lower DFS and 5-year survival rates than patients with positive RECK expression.In addition,for node-negative breast cancer ,negative RECK expression indicated markedly unfavor -able survival rate than positive arm .Multivariate analysis further confirmed that RECK expression was an inde -pendent prognostic factor for patients with breast cancer .Conclusion The loss of RECK expression indicates un-favorable survival rate for patients with breast cancer .RECK expression is a new ,important risk factor for recur-rence in breast cancer .
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