Objective:To observe the effect of simvastatin at different doses on the inflammatory factors and renal function in se-nile patients with diabetic kidney disease ( DKD) . Methods:Totally 160 cases of DKD patients were randomly divided into the control group, low dose group, conventional dose group and high dose group. All the patients were given the foundation treatment, and the low dose group, conventional dose group and high dose group was respectively given simvastatin 10, 20,40 mg·d-1 . The changes of in-flammatory cytokines (CRP, ICAM-1 and IL-1β) and renal index (BUN, Cr, UAER, 24hUpro and Uβ2-MG) among the groups were observed and compared before and after the 4-week treatment. Results:CRP in the high dose group after the treatment was significantly decreased when compared with that before the treatment and that in the control group after the treatment, and the difference was statisti-cally significant (P<0. 05). ICAM-1 in the low dose group, conventional dose group and high dose group was significantly decreased when compared with that before the treatment and that in the control group after the treatment, and the difference was statistically sig-nificant (P<0. 05). IL-1β in the four groups after the treatment had no obvious change when compared with that before the treatment, and there was no significant difference among the groups (P >0.05). BUN in the four groups after the treatment had no obvious change when compared with that before the treatment, and there was no significant difference among the groups (P>0. 05). Cr and UAER in the four groups after the treatment were significantly decreased (P<0. 05), those in the low dose group, conventional dose group and high dose group after the treatment were significantly lower than those in the control group after the treatment (P<0. 05), and those in the conventional dose group and high dose group after the treatment were significantly lower than those in the low dose group after the treatment (P<0. 05). 24hUpro in the low dose group, conventional dose group and high dose group after the treatment was significantly decreased when compared with that before the treatment and that in the control group after the treatment (P<0. 05). Uβ2-MG in the low dose group, conventional dose group and high dose group after the treatment was significantly decreased when com-pared with that before the treatment and that in the control group after the treatment (P<0. 05), that in the conventional dose group and high dose group after the treatment was significantly decreased when compared with that in the low dose group after the treatment (P<0. 05), and that in the high dose group after the treatment was significantly lower than that in the conventional dose group after the treatment (P<0. 05). ③There was no statistically significant difference in the adverse reactions incidence among the four groups (P>0. 05). Conclusion:Simvastatin can improve diabetic nephropathy conditions in two aspects of inflammation factors and renal in-dex, and simvastatin at high dose shows more advantages.

0.05), reduced obviously in hydrotherapy group as compared with sham group. Postsynaptic density (PSD) in hippocampus was more in intervention group than non-intervention group. Conclusion Enriched environment stimulus and hydrotherapy can promote the rehabilitation of neonatal rats with HIBD. The intervention effects of enriched environment and combined application of enriched environment stimulus and hydrotherapy is better than hydrotherapy. The change of NMDA receptor in hippocampus might be one of the mechanism.

0.05).There was a negative correlation between PASP and the level of H2S in 3 groups at time points of pre-operation,1 h and 24 h post-operation (pre-operation,r=-0.66,P

OBJECTIVE:To compare the therapeutic effects of taurine and catalin eye drops.METHODS:All the mice were divided into the normal control group,the cataract control group,the taurine group and the catalin eye drops group.Except the normal control group,the rest ones were used to establish the galactose cataract models and then received eyedrop administration everyday.The contents of taurine,glycin and glutamic acid in crystalline lens were measured by high perfor?mance liquid chromatography.RESULTS:The contents of amino-acids were not found lower in the taurine group as com?pared with the catalin eye drops group.CONCLUSION:Taurine shows the preventive and therapeutic effects on the experi?mental cataract,which can be comparable to that of catalin eye drops or even more advantageous.

With the special organization structure and function,retina is thought to be a prime candidate for developing the cellular therapies.Many types of stem cells have been explored to use for the treatment of retinal diseases and exhibit significant potential for further clinical application.However,before these results are translated to a clinical setting,sufficient investigations are required,such as the selection of the type of stem cells,transplantation strategy,the mechanism of therapeutic effect and biological safety,and how to get high differentiation efficiency,clarify the best development phase before transplantation,and achieve effective functional and structural integration of stem cells in the retina,etc.

Hearing loss caused by cochlear damage is the main symptom of sudden deafness (SD). Some patients also suffer from vestibular symptoms. In recent years, more attention has been paid to the vestibular dysfunction in patients with SD. The lesions could involve the whole inner ear in SD patients with and without vertigo. Comprehensive evaluation of vestibular function may help us understand the extent of lesions in sudden deafness and analyze the pathogenesis of disease. A less involvement of inner ear lesion may indicate a better hearing recovery.
Cochlea ; injuries ; Hearing Loss, Sudden ; diagnosis ; pathology ; Hearing Tests ; Humans ; Vertigo ; Vestibule, Labyrinth ; physiopathology

OBJECTIVETo construct a 3D finite-element model of the craniofacial complex with the original DICOM data of CT and to investigate the preliminary biomechanical characteristics with different directions and magnitudes of retractive forces to the maxilla of rhesus monkeys.

METHODSA male rhesus monkey with mixed dentition was used. Spiral CT was performed to establish a 3D finite-element model of the craniofacial complex. The ANSYS 12.1 software was used to analyze craniofacial complex displacement.

RESULTSEach landmark showed larger displacement with increasing force value. The displacement values and force size exhibited a linear relationship. In the x-axis direction, all displacements were small. In the y-axis direction, all displacements showed significantly higher changes with increasing force value displacement. In the z-axis direction, the A-point and ANS point moved downward, but PNS moved upward.

CONCLUSIONLoading retractive force resultes in an apparent backward and clockwise rotation on the maxilla with no obvious effects on the width of the upper jaw.

Objective To observe and study the influence state of ulinastatin for multi system function state of patients with acute abdomen during the the perioperative period.Methods 60 patients with acute abdomen treated with operation in our hospital during the time of October 2015 to July 2016 were selected as the research object, and they were randomly divided into control group ( conventional perioperative treatment group ) 30 cases and observation group(conventional treatment and ulinastatin group)30 cases,then the liver function,renal function,gastrointestinal function and immune function related indexes of two groups before the operation and at second,fifth and seventh day after the operation were detected and compared.Results The liver function,renal function,gastrointestinal function and immune function related indexes of two groups before the operation were compared ,,while the liver function,renal function,gastrointestinal function and immune function related indexes of observation group at second,fifth and seventh day after the operation were all significantly better than those of control group(P<0.05),those detection results of two groups after the operation all had significant differences.Conclusion The ulinastatin can effectively protect multi system function state of patients with acute abdomen during the the perioperative period,so its application value in these surgical patients is higher.

Monocyte chemoattractant protein-1 (MCP-1) is a cytokine which belongs to the CC chemokine family.Retinal pigment epithelium (RPE) cells,photoreceptors and microglial cells in the retina can secrete MCP-1.Physiological level of MCP-1 is important for preserving morphology of RPE and glial cells,as well as retinal function and gross morphology.MCP-1 is likely released from Müller glia and the RPE cells when retina under stress,and attracts microglia/macrophages to the sites of retinal damage,activates the microglia to ingest cell debris.MCP-1 has been found upregulated in the intraocular fluid of retina in patients and animal models with retinal detachment,posterior uveitis and age-related macular degeneration.The expression of MCP-1 may be response to retinal inflammation.Therefore,it is tempting to speculate that pharmacological targeting of MCP-1 may be a safe and viable strategy in treatment of retinal disease.

Objective To reveal the main authors, institutions and countries and analyze their cooperation models by plotting the cooperation network knowledge map of highly cited papers on diabetes mellitus published in 2004-2013 .Methods The cooperation network knowledge map was plotted using the visual software Citespace for the au-thors , institutions and countries that published highly cited papers on diabetes mellitus in 2004-2013 .Results The core authors were Graham Nichol, SM Grundy and Hertzel C.Gerstein, etc.The cooperation in teams was close while the cooperation between teams was rare.The core institutions were Harvard University, Brigham and Womens Hospital, University of Sydney, etc.Universities played the important role in scientific research.The most influential countries were USA, Britain and Canada which had a very close cooperation between each other.Conclusion Single point type, double core type, development type and complete type are the cooperation models of authors, institutions and countries that published highly cited papers on diabetes mellitus in 2004-2013.Geoproperty-and institutional property-based cooperation is still in its infancy, cooperation and exchange should thus be strengthened between cities, between universities, between medical institutions , between general institutions and scientific institutions .