1.The clinical significance of a new model with emergency triage information system combined with pre-registration during the emergency process
Chinese Journal of Emergency Medicine 2017;26(7):802-806
Objective To explore the clinical significance of a new model with emergency triage information system (ETIS) combined with pre-registration during the emergency process.Methods A total of 1 000 patients who applied the new model with ETIS combined with pre-registration from January to April 2016 were assigned as the observation group,while another 1 000 patients from January to April 2015 who applied the conventional model with triages were assigned as the control group.The used time of triage,used time of registration,collection conditions of vital signs,and accurate rate of triage were compared between these two groups.Meanwhile,mortality,rescue success rate,omission rate,excessive-detection rate,transferring surgical duration,as well as door-to-needle time (DNT) and percutaneous coronary intervention (PCI) time in red region,were compared between these two groups.Results Subjects in the observation group had notably shorter used time of triage and registration,prominently higher accurate rate of triage,markedly better collection conditions of vital signs (P < 0.01),obviously lower mortality,omission rate,excessive-detection rate,transferring surgical duration,DNT and PCI time (P < 0.05),and significantly higher rescue success rate (P < 0.01),compared with patients in the control group.Conclusions The application of the new model with ETIS combined with pre-registration has high clinical significance.It greatly optimizes the emergency process,significantly shortens patient's triage and registration time,promotes the accurate rate of triage,allows the rapid and complete collection of vital signs,and more importantly,it also improves the time for rescuing critical patients,tremendously raises the rescue success rate and reduces mortality.
2.Exploration of rabbit respiration regulation and respiratory failure designing experiment
Chinese Journal of Medical Education Research 2006;0(07):-
The article expatiated on the process of rabbit respiration regulation and respiratory failure designing experiment.It can fully excitate students'potential and strengthen the teaching effects.It is very important for cultivating students'synthesis diathesis and abilities.
3.Combined anterior and posterior operation in the treatment of 50 cases with cervical spondylotic myelopathy
Chinese Journal of Primary Medicine and Pharmacy 2014;21(6):886-887
Objective To explore the clinical efficacy of combined anterior and posterior operation in the treatment of cervical spondylotic myelopathy.Methods 50 patients with cervical spondylotic myelopathy,in accordance with anterior,posterior surgery and combined anterior and posterior operation three different surgical methods,were divided into the treatment group A(21 cases),group B(16 cases) and group C(13 cases).The surgical efficacy was analyzed.Results Before treatment,the JOA score among the three groups had no significant difference [Cgroup (9.3 ± 2.3) points,B group (9.4 ± 1.4) points,A group (9.2 ± 2.2) points].After treatment,the JOA score in group C (14.5 ± 3.4) points was significantly higher than that of group A (12.6 ± 1.2) points (t =3.09,P <0.05) and group B (11.3 ± 1.4) points (t =4.62,P < 0.05).The excellent and good rate of C group was 76.9%,which was significantly higher than that in group A 43.8% (x2 =3.84,P < 0.05) and group B 42.8% (x2 =4.11,P < 0.05).Conclusion Combined anterior and posterior operation in the treatment of cervical spondylotic myelopathy has better recovery of spinal cord function,complete decompression,significant effect,less complications,etc.,it is an effective,safe and reliable treatment.
4.Advances in treatment of radiation of non-small-cell lung cancer in the 15th World Conference on Lung Cancer
Cancer Research and Clinic 2014;26(2):73-75
The 15th World Conference on Lung Cancer (WCLC) received about 210 abstracts on radiotherapy.These abstracts covered many realms,including the efficacy,safety,evaluation methods and dose fractionation study of stereotactic body radiotherapy (SBRT) on early stage non-small-cell lung cancer (NSCLC); control studies of high and standard radiation dose,different chemotherapy regimens and whether combined cetuximab in concurrent radiochemotherapy on locally advanced NSCLC clinical significance of postoperative 3D-conformal radiotherapy (3D-CRT) for patients with p Ⅲ A-N2 NSCLC after complete resection; the efficacy and safety of TKIs in combination with whole brain radiation therapy (WBRT) in NSCLC patients with multiple brain metastases,as well as the influence of EGFR mutation status on the curative effect.Besides,there are many reports about radiotherapy protection,toxicity,efficacy,prognosis and life quality assessment.
5.Progress in integrin in acute leukemia
Journal of Leukemia & Lymphoma 2016;25(8):506-508
Acute leukemia (AL) is an early hematopoietic stem/progenitor cell malignant cloning disease.Minimal residual disease and drug resistance are considered to be the origin of relapse and refractory.Recently,more and more evidences have shown that the interaction between leukemia cells and stromal cells or extracellular matrix in the bone marrow microenvironment can promote their survival,and enhance the resistance to conventional chemotherapy drugs.Integrin is the major molecule mediating the adhesion between leukemia cells and extracellular matrix (cellular and non cellular components),which plays a key role in cell proliferation,survival and other biological processes;however,the mechanism is not fully understood yet.This paper will review molecular mechanisms of the relationship between integrin and AL discovered recently.
6.Research on value of different administration models of tiotropium bromide applied to treat asthma combined with COPD
Chinese Journal of Biochemical Pharmaceutics 2016;36(4):58-60
Objective To explore clinical value of different administration modes applied to treat the asthma combined with chronic obstructive pulmonary disease ( COPD ) .Methods Clinical data of 180 patients with bronchial asthma combined with COPD admitted by the department of respiratory medicine of the Hospital from June 2013 to June 2015 were retrospectively analyzed, and such patients were divided into three groups including 58 patients in the control group, 60 patients in the observation group A and 62 patients in observation group B ( n =62 ) in random cross double-blind method.The patients in the control group were administered and treated with placebo ( once in the morning and at night daily respectively) , the patients in the observation group A were administered and treated with 2.5 μg of tiotropium bromide ( once in the morning and at night daily respectively), and the patients in the observation group B were treated with 2.5 μg of tiotropium bromide (once at night daily respectively), and the treatment efficacy on three groups of patients were observed.Results Average questionnaire scores of FEV1, AUC0 ~24 h , FEV1(0 ~24 h) peak valley value, PEFam , PEFpm , FEV1 and ACQ -7 in 24 hours of patients in the observation group A and observation group B, there were no statistically significant differences between two groups;Questionnaire scores of FEV1, AUC0 ~24 h , FEV1(0 ~24 h) peak valley value, PEFam , PEFpm , FEV1 and ACQ-7 in 24 hours of patients in the observation group A and observation group B were significantly higher than such indexes of patients in the control group, and the differences were statistically significant ( P <0.05 ) .Conclusion Two different dosage regimens of tiotropium bromide with daily dose of 5 μg can significantly keep the bronchus expanding for 24 h, and delivers significant efficacy on the asthma combined with COPD treatment.
7.Quantitative Determination of Endotoxin Concentration in PVC Disposable Transfusion Set by Limulus Test
China Pharmacy 1991;0(02):-
This paper recommends the quantitative determination of endotoxin in PVC disposable transfusion set by limulus test for the first time in our country. The data obtained can act as reference material for eontroling the quality of the transfusion set. The p-nitroaniline staining combined with spectrophotometry was used in this study. The precision, sensitivty and repetition rate of this method were satisfactory. We conclude that this method is an ideal one for quantitatively determining endotoxin in PVC transfusion set.
8.Research progress in the relationship between adipokines and breast cancer
Cancer Research and Clinic 2013;(3):208-210
Research on the relationship between obesity and breast cancer has been deepened in recent years.Obese breast cancer patients have poorer prognosis than normal-weight patients.Weight variation is correlated with relapse in breast cancer survivors.The role of adipokines in this process can not be ignored.The correlations between adipokines,estrogen,cell proliferation,angiogenesis and breast cancer prognosis are reviewed in this article.
9.The curative effect observation of combined octreotide and omeprazole for the treatment of esophageal variceal bleeding
Chinese Journal of Primary Medicine and Pharmacy 2015;(5):717-719
Objective To explore the clinical effect of combined octreotide and omeprazole for the treatment of bleeding of esophageal and gastric varices(BEV),analyze its security and provide objective basis for clinical treatment.
Methods 92 patients with BEV were randomly selected .According to the treatment methods , they were randomly divided into the control group and observation group .45 cases in the control group were treated with octreotide ,47 cases in observation group were treated with omeprazole on the basis of the control group .The main indexes were the treatment effect,48h rebleeding rate,bleeding time and volume of blood transfusion and adverse reaction .Results The total effective rate of the observation group was 93.62%,more than that of control group 82.22%,the difference was statistically significant(χ2 =6.24,P<0.05).The effective rate of the observation group was 6.38%,lower than that of the control group 17.78%,the difference was statistically significant (χ2 =6.17,P<0.05).The bleeding time of the observation group was (30.41 ±1.82) h,less than that of the control group (41.83 ±2.69) h,the difference was statistically significant (t =9.47,P <0.05).The blood transfusion of the observation group was (374.16 ± 28.30)mL,less than the control group(582.33 ±36.19)mL,the difference was statistically significant (t=12.31, P<0.05).48h the rebleeding rate of the observation group was 6.38%,lower than that of the control group 20.00%,the difference was statistically significant (χ2 =5.90,P<0.05).The adverse reactions of two groups had no significant difference(χ2 =2.78,P>0.05).Conclusion There is the better for clinical effect of combined octreoti-de and omeprazole for the treatment of BEV , which could reduce the rebleeding rate , shorten the bleeding time , decrease the volume of blood transfusion ,and there was no obvious adverse reactions .
10.Study thought on diagnosis of TCM syndrome in animal model of modern medicine disease
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(10):-
To define the diagnostic thought on TCM syndrome in animal model of modern medicine disease.To diagnose "apparent syndrome" outside and "hidden syndrome" inside of TCM syndrome differentiation existed possibly in the model animal by multi-aspectual indexes such as observing the appearance of modeled animal,examining the laboratory indexes and morphology,disproving by prescription and medicine etc.It is an effective method of diagnosing TCM syndrome in animal model of modern medicine disease that using multi-aspect and multi-index diagnostic standard.