Objective To explore the efficacy and safety of multimodality analgesia for patients undergoing radical resection of colon cancer.Methods Seventy patients aged 46-75 years old,undergoing the radical resection of colon cancer were divided randomly into two groups:the trial group (parecoxib preemptive analgesia and ropivacaine local analgesia combined with sufentanil patient-controlled intravenous analgesia) and the control group (sufentanil patient-controlled intravenous analgesia only),each group of 35 patients.The visual analogue scale (VAS) and the usage amount of sufentanil were recorded at 12,24,48 h after operation.The number of unsatisfied demand and the number of successfully delivered doses,sufentanil consumption at 12 h and 24 h after operation,the patients' global evaluation of the postoperative analgesia and adverse effects related to analgesia were recorded and compared between the two groups.Results The VAS scores at 12,24 h after operation in trial group were lower than those in control group [(3.1 ± 1.0) scores vs.(4.0 ± 1.3) scores,(2.8 ± 1.4) scores vs.(3.7 ± 1.2) scores].The degree of satisfaction in trial group was higher than that in control group(P ＜ 0.05).The demand and the number of successfully delivered doses and the usage amount of sufentanil in trail group were significantly lower than those in control group (P ＜ 0.05).The incidence of respiratory depression,nausea and vomitting in trial group were significantly lower than those in control group[0 vs.5.7％(2/35),2.9％(1/35) vs.11.4％ (4/35)] (P ＜ 0.05).Conclusion Multimodality analgesia may have the good analgesic effect in the patients undergoing radical resection of colon cancer,and with fewer adverse events.

Caudate lobectomy is still a great challenge for surgeons due to unique anatomy of caudate lobe.A 38-year-old male patient with a huge recurrent hepatic cancer (diameter =16 cm) in caudate lobe received caudate lobectomy with portal triad and inferior vena cava clamping.The operation was paused due to hemorrhage (volume of blood loss =1000 ml).After heat preservation and blood transfusion,the caudate lobectomy was completely removed with inferior vena cava clamping.The patient gradually recovered,and no tumor recurrence was detected during the follow up (14 months).Caudate lobectomy could be safely carried out under the condition of accurate preoperational estimation,clear indication for surgery and precise hepatectomy.

Objective To investigate the role and expression of serum substance P (SP) in the patients with breast cancer.Methods The quantity of serum SP by using ELISA in 21 patients with breast cancer (breast cancer group) and 10 healthy women (control group) were detected,the data were analyzed according to AJCC guide line.Results The positive rate of serum SP in breast cancer group was significantly higher than that in control group [57.1％ (12/21) vs.0] (P ＜ 0.01).The level of serum SP in breast cancer group was significantly higher than that in control group [(240.14 ± 435.04) ng/L vs.(16.80 ± 11.74) ng/L](t =2.9852,P ＜ 0.01).There was no relationship between serum SP and estrogen receptor in the patients with breast cancer (t =0.1856,P ＞ 0.05).The level of serum SP showed significantly difference according to AJCC stages respectively (F =3.24,P ＜ 0.05).Conclusion The level of serum SP in the patients with breast cancer increase and may play a role in the progress of breast cancer.

Biliary cystic tumors (BCTs) are rare cystic tumors and are accounted for less than 5％ of liver cysts.BCTs are very common in middle-aged and elderly women,and depend on diagnosis of imaging including papillary projection or multilocular cystic liver mass.BCTs are frequently misdiagnosed due to the absence of specific diagnostic indicators,which should differentiate from diagnosis of hepatic cystic.Complete surgical resection is the first choice for BCTs with a good out-come,in addition to low recurrence.Once recurrence was identified in follow-up,BCTs can be treated by reoperation with a good outcome.

Objective To summarize and analyze the examination result of serum specific IgE in patient with allergic skin disease,and seek the cause of disease for the allergic skin disease patient and provide the clinical treatment basis.Methods The serum specific IgE of ingestion and inhalation were detected by enzyme-linked immunoassay in 529 patient with allergic skin disease.Results In 529 cases,the serum specific IgE of inhalation and ingestion were positive in 336 cases,and simple positive of inhalation were in 92 cases,and simple positive of ingestion were in 51 cases.In the inhalation group,D1,1D2 (dust mites,mites) was highest,followed by T3,T8,T11,T18,T70 (birch,elm,eucalyptus,and indus,and the mulberry tree) and H1 (house dust).In the ingestion group,F13,F17 (peanut,hazelnut) was highest,followed by F3,F40,F37 (COD,tuna,scallop),F47,F48,F263 (garlic,onion,green pepper).In 14 items,more than one item were positive in 96.2％.Concluslon Detecting allergic skin disease patients serum allergen specific IgE can guide patient awareness of their allergen and clinical treatment,which has effect on allergic skin disease prevention and treatment.

Objective To understand the distribution characteristics of HIV infection status among the outpatients in this hospi-tal to provide the beneficial supplement for local large-scale survey and the basis especially for the hospital infection control.Meth-ods The HIV screening situation on the outpatients of our hospital from 2007 to 2012 was retrospectively analyzed.Results Dur-ing these 6 years,108 999 specimens were detected,88 cases were positive in the preliminary screening and 81 cases were confirmed positive.The positive rate of anti-HIV antibody was 0.074%.In addition to voluntary counseling and testing,the specimens submit-ted by the outpatient anorectal department and the inpatient hematology department had the higher positive detection rate,which was 1.16% and 0.84% respectively.Conclusion The HIV infection rate in non-infectious disease specialized hospitals shows the increasing trend.The key departments must increase the intensity of the medical staff training,pay attention to early diagnosis of HIV/AIDS,prevent the hospital infection and reduce the risk occurred after the occupation exposure.

China ; Surgery/*history

Objective To study and analyze the clinical application of five kinds of antihypertensive drugs in Department of cardiology. Methods In our hospital from January 2015 to December 2016 treated 100 cases of oral antihypertensive drugs in cardiovascular disease patients as the research object of this study, retrospective analysis of clinical data of patients, medication of patients, the system analysis of selected patients with medication, including patient name and the category, record the daily dose and the drug combination. Evaluation was made by using frequency index and index of utilization of drugs. The standard of rational drug use is drug utilization index (<1). Results After the corresponding analysis, the number of available urine drugs was 32 cases, the utilization rate was 32%. The number of use of beta blocking drugs was 28, with a utilization rate of 28%. The number of use cases of calcium antagonists was 20 cases, and the utilization rate was 20%. Angiotensin converting enzyme inhibitors were used in 14 cases, with a utilization rate of 14%. The use of angiotensin receptor Ⅱ blockers was 6 cases, with a utilization rate of 6%. Five of the three antihypertensive drugs were diuretic drugs, beta blockers and calcium antagonists. The highest frequency of use of metoprolol was 25%. The number of cases with furosemide was 13, and the frequency of medication was 13%. The number of drugs used in Extended Release Nifedipine Tablets was 12 cases, and the frequency was 12%. After the research, we can conclude that the combination of two or triple drugs is more effective in the combined use of hypertension. The utilization index of Hydrochlorothiazide Tablets and amlodipine tablets was greater than 1, and the other drugs met the standard of rational use. Conclusion The rational use of antihypertensive drugs can guarantee the effect of treatment to some extent, help patients to stabilize blood pressure, improve the quality of life of patients.

s international forum of higher education focused on the theme of characteristics,personality and a powerful country with talents and the common understanding was reached.That is only by orientating scientifically,running characteristically and cultivating more and more talents of high quality,personality and creativity,can Chinese higher institutions of learning shoulder the historical task entrusted by the strategy of propelling China to be a power country of opulent human resource.

Carrying forward the reform of quality education in universities,we should pay more attention to the integration of specialized education and general education,emphasize the training of creative competence,and never neglect the cultivation of the humane quality,which is the original purpose of quality education.