Objective To study the curative effect of luterinizi releasing hormone anogist(LRH-A) with Zhibaidihuang pill treatment for girls idiopathic true precocious puberty(ICPP).Methods 29 girls with ICPP,the breast in 3rd period were selected.9 of them were treated with LRH-A,12 of them were treated with LRH-A and Zhibaidihuang pill,8 of them as comparison group were no-treated.The growth speed,secondary sexual characteristics,bone age,LHRH inspire experiment,ultrasonic measurement of uterus volume and ovarian follicle size and forecast target of height were separately tested before and after treatment.Results Two groups after 4 period of treatment were compared:one group after only treated with LRH-A,the average growth speed was lower;The predict final target of height was not obviously increased;The secondary sexual characteristic reduced;The blood lever of E2,FSH and LH differ decreased;The bone age had no change.The other group after bio-treated with LRH-A and Zhibaidihuang pill,the average growth speed was slow down(P

The characteristics of C8051F340 MCU and USB communication, and the design method of system's hardware and software structure are introduced briefly. The whole system is proved stable and reliable by experiment. The Universal Serial Bus (USB) communication technology has great value in course of system design and study.

The suceptibilities of ascitic S180 cells to NK cell-mediated binding and killing during their development in vivo were studied at a single cell level, usingsingle cell cytotoxic and binding assaies. The results showed that the NK binding and killing suceptibilities of ascitic S180 cells changed sequentialy during their growth in vivo, the kinetics of which had an appearence of reversed S with both NK binding and killingsuceptibilities being the highest at the fifth day and the lowest at the second day and the tenth day after inoculation of the tumors. However, the changes were seen to be similar when the tumors were inoculated in either adult(6-7-week-old) or yaung(3-week-old) mice, or in different strains of adult mice. Analysis at a single cell level revealed that the change in the NK suceptibilitg of the tumor cells at different growth stages were concomitant with the changes in the number of the tumor target cells capable of being bound by NK cells as shown with an NK-target binding assay, which was consistant to the flactuation of the capability on which the tumor target cells could bind more than one NK cell. Our results indicate the NK-suceptibility of ascitic S180 cells changes uring their growth in vivo, due to the changes of the ratio of NK-suceptible and-nonsuceptible target cells in the tumor cells at different growth stages. The possible cause(s) for the changes is discussed here.

Objective To investigate the expression of extracellular matrix metalloproteinase inducer CD147 in patients with bladder urothelial carcinoma and its relationship with clinicopathologic features and prognosis.Methods RT-PCR and Western blot were used to evaluate the mRNA and protein expression of CD147 in cancer tissues and corresponding paracanerous tissues from 20 patients with bladder urothelial carcinoma;tissue microarray containing specimens from 108 patients with bladder urothelial carcino-ma and 20 normal controls was constructed and immunohistochemistry was applied to examine the expression of CD147,and the correlations between CD147 and clinicopathological characteristics and prognosis were also analyzed.Results Expression level of CD147 mRNA and protein in cancer tissues from 20 bladder urothelial carcinoma patients was significantly higher than that of cor-responding adjacent tissues(P<0.01).Immunohistochemical detection showed normal bladder urothelium from 20 control cases were either no or weak protein expression of CD147,positive expression rate of CD147 in 108 cases of bladder urothelial carcinoma was 73.1%.the CD147 expression level had positive correlation with lymph nodes metastasis,histological grade,tumor stage and tumor size of patients with bladder urothelial carcinoma(P<0.05)and had no relationship with age,sex,the number of tumor(P>0.05).Kaplan-Meier survival curves analysis showed that the survival time of patients with bladder urothelial carcinoma whose ex-pression of CD147 were high was significant lower than that of patients with bladder urothelial carcinoma whose expression of CD147 were low(P<0.01).Univariate analysis showed that histological grade,tumor stage,lymph node metastasis,tumor size and CD147 expression were all positively correlated with a poor prognosis(P<0.05).Cox-multivariate analysis revealed that histologi-cal grade,tumor stage,lymph node metastasis,and CD147 expression level were independent predictors of an unfavorable prognosis (P<0.05).Conclusion High expression of CD147 in bladder urothelial carcinoma may be correlate with the its progress and its expression state is an independent prognosis factor.

This paper introduces the so ftware development method of the driver for the auto-weatherstation under the s ituation of configuration software,which is to realize the data collection.The m ethod has a bright future in the market and its application.

The Milestones has become an important component of Graduate Medical Education (GME) of the United States, and the Milestones Guidebook (2016) can help understand and implement the Milestones and improve graduate medical education and practice.This article outlines the basic principles of the Competency-Based Medical Education (CBME) and the Milestones, introduces the guidelines and responsibilities of related stakeholders in Implementing and Using Milestones Effectively, and highlights the Importance of Assessment and Feedback.The Milestones includes 6 core competencies to be achieved in skills, knowledge, and behaviors, its formative process, the causes of its development, and its effective implement and application.The Milestones is the development of CBME and designed to help all practitioners make highly competent physicians.The primary objective of this program is to cultivate trustworthy medical graduates and provide high-quality health care to the general public.

Co-citation analysis, co-word analysis and strategic coordinates are combined to make known the subject theme evolu-tion. The research history of general surgery is described by eo-citation eluster analysis, citation strategic diagram is pictured by the theory of strategy coordinates to learn more about the novelty and attention of each hot topic. The present research focused on general surgery that would be found by co-words cluster analysis, and stages of development about each topic are discussed by strategic coordinates based of cluster results. It is helpful to provide a decision-making reference for professionals and managers.

OBJECTIVE: To observe the effects of different maintain doses of Dexmedetomidine on plasma cortisol and glucose during anesthesia recovery period in patients undergoing uvulopalatopharyngoplasty under sevoflurane inhalation anesthesia. METHOD: In this prospective, randomized, double-blind study, 120 ASA I and II patients undergoing selective uvulopalatopharyngoplasty under general anesthesia were included. The patients were randomly allocated to three groups (n = 40): Dexmedetomidine low maintain dose group (D1), Dexmedetomidine high maintain dose group (group D2) and control group (group C). The Dexmedetomidine groups and control group were given Dexmedetomidine 1 microg/kg and normal saline in 20 ml within 15 min just before induction of anesthesia. Then Dexmedetomidine were maintained at 0.2 microg x kg(-1) x h(-1) and 0.7 microg x kg(-1) x h(-1) in group D1 and group D2 and were withdrawed 5 min before the end of operation, the same maintained speed of normal saline was given in group C. BIS value was maintained at 40-60 by adjusting the inhaled concentration of sevoflurane. Anesthetic was withdrawed 10 min before the end of operation. Thus, plasma cortisol concentration and blood glucose was needed to be detected just before anesthesia (T0), tracheal extubation (T1), 5 min after extubation (T2) and 15 min after extubation (T3). Duration of operation and anesthesia, consumption of sevoflurane, emergence time, extubation time, the occurrence of dysphoria, bucking and hypoxemia (SpO2 < 90%) during extubation were recorded. RESULT: Compared with group C, MAP and HR at T1, plasma cortisol concentration and blood glucose at T1 - T3 were all significantly lower in group D1 and group D2 (P < 0.05), and so were the consumption of sevoflurane and the occurrence of dysphoria (P < 0.05). The emergence time and extubation time were significantly prolonged in group D2 compared with group D1 and group C (P < 0.05). There was no significant difference in the occurrence of bucking and hypoxemia in three groups (P > 0.05). CONCLUSION In the patients undergoing UPPP under sevoflurane inhalation anesthesia, Dexmedetomidine infused at 0.2 microg x kg(-1) x h(-1) maintains a stable hemodynamics without respiratory depression, alleviates stress response during extubation and reduces both the consumption of sevoflurane and the occurrence of dysphoria without prolonging emergence time and extubation time.
Adult ; Anesthesia Recovery Period ; Anesthesia, Inhalation ; Blood Glucose ; metabolism ; Dexmedetomidine ; administration & dosage ; Double-Blind Method ; Female ; Humans ; Hydrocortisone ; blood ; Hypnotics and Sedatives ; administration & dosage ; Male ; Methyl Ethers ; Middle Aged ; Otorhinolaryngologic Surgical Procedures ; Palate, Soft ; surgery ; Pharynx ; surgery ; Sevoflurane ; Uvula ; surgery

Objective To study the effect of in utero exposure of TCDD on synthesis of EGF and EGFR in submandibular gland of rat offspring. Methods SD rats were treated with TCDD 5??g/kg on Day 15 of gestation, the expression of EGF and EGFR in submandibular gland of rat offspring were analyzed by immunohistochemistry method. Results On PND32 and PND49, the expression of EGF and EGFR in TCDD experiment group were more than that of control group, the difference was statistically significant.Conclusion In utero exposure of TCDD can promote the synthesis of EGF and EGFR in submandibular gland of rat offspring from prepuberty stage through puberty stage. [