Objective:To explore the effect of Weishenjiang Liquor on immune function in mice.Methods: Feeding mice with 8.5, 17, 50ml/kg Weishenjiang Liquor which contains 10mg/dl polysaccharide continuously for 28d, were determined the spleen index, chest gland index, phagocytosis of monocytes phagocytes, activity of NK cell, hemolysin formation, lymphocyte transformation and DTH test.Results: Phagocytosis of monocytes phagocytes, NK cell activity, hemolysin formation, lymphocyte transformation rate were increased in mice with a dose of 50ml/kg group. Conclusions: Weishenjiang Liquor has the function of strengthening cellular and humoral immunization in high dose.