Objective To investigate the relationship of D-dimer(DD) and fibrinogen levels in blood plasma and diabetic nephropathy(DN).Methods According to the results of urinary albumin excretion rate (UAER), 98 cases of type 2 diabetas were divided into simple diabetic mellitus ( SDM), early diabetic nephropathy ( EDN) and clinical diabetic nephropathy (CDN); other 45 healthy persons were employed as control. Plasma levels of DD and the fibrinogen of all groups were examined.Results There was significant difference of DD and fibrinogen levels in all groups as compared with control group (P

Objective To investigate the diagnostic value of biexponential model of DWI in nontypical hippocampal sclerosis (HS) of the youth.Methods DWI with multiple b values were performed on 75 youths with right temporal lobe epilepsy and 20 healthy youths(control group).There were no abnormalities in hippocampus on conventional MRI.11 of 75 patients were proved right HS by surgery and pathology (HS group).Compare the volume of the right hippocampus and their D,D? and f values in HS group and control group.Results There were statistical differences in D and f values between HS group and control group (Z=-3.08,Z=-2.23,P<0.05). There were no statistical differences in the volume of hippocampus and D? values between two groups (Z=1.77,Z=-0.19,P>0.05). Conclusion When HS does not have typical appearances on conventional MRI,D and f values can provide help from diffusion and the perfusion of microcirculation aspects.

Lower urinary tract symptoms due to benign prostatic hyperplasia is of great prevalence among ageing males,and it can markedly affect patients' quality of life.Personalized drug therapy according to genetic characteristics is the ideal choice for this problem.Here we summarized the latest research findings on the associations of gene polymorphisms with drug efficacy and adverse reaction in the treatment of benign prostatic hyperplasia/urinary tract symptoms.

Child ; Combined Modality Therapy ; Drugs, Chinese Herbal ; administration & dosage ; Eye Diseases ; drug therapy ; therapy ; Female ; Humans ; Middle Aged

Objective To investigate the characterized imaging in conventional MRI, get information about the metabolites in basal ganglia from proton MR Spectroscopy(~1H-MRS) of acute bilirubin encephalopathy(ABE) and find out the relationship between those changes and bilirubin levels. Methods Twenty-eight patients with acute bilirubin encephalopathy and 15 normal neonates underwent MR and ~1H-MRS examinations T_1 WI, T_2WI and DWI were collected via conventional MRI scanning of all neonates. All patients underwent multi-voxels scanning and 15 of them had single voxel scanning. ~1H-MRS used point resolved spectroscopy (PRESS) both in multi-voxels and single voxel scanning. The data of them were acquired from the ROIs placed in basal ganglia and globus pallidus, respectively. The metabolites including NAA choline, Lactate, glutamate and glutamine, myoinositol and creatine were quantitatively analyzed to compare them between the control group and the case group. Equality of variance between patient data and normal values were tested by using the two-tailed t test. The case group was divided into three groups of 342.0 μmol/L < TSB ≤ 427. 5 μmol/L,427.5 μmol/L < TSB ≤ 513.0 μmol/L, TSB > 513.0 μmol/L including 8,9,11 patients, respectively. Analysis of variance was used for statistics. Results Conventional magnetic resonance imaging showed symmetrical high signal of T_1WI in globus pallidus of 23 patients. The case group and the control group were significantly different. Single voxel ~1H-MRS revealed that the relative concentrations of Glx/Gr and mI/Cr in the control group were 0.95±0.23, 0.57±0.20, respectively, While those in case group were 1.45±0.37, 0.74±0.23, respectively. There were significant differences between two groups (t =2. 13,4. 40,P =0.04,0.00 respectively). Multi-voxels scanning 1H-MRS revealed that Glx / Cr were 0.51±0.36 in case group and 0.29±0.18 in control group. There was also a significant difference between two groups (t =2.17,P =0.03). And the values of Cho/Cr, NAA/Cr and Lac/Cr were not significantly different. The results were same in multi-voxels ~1H-MRS. Total bilirubin level and the concentration of metabolites in the brain do not have obvious correlation. Conclusions ABE has a characteristic signature which is symmetrical high signal of T_1 WI in globus pallidus on conventional MBI; The values of mI/Cr and Glx/Cr remarkably increase as detected by ~1H-MRS, which is generally in agreement with what has been known about bilirubin pathology.

o statistical difference between WMD group and control group (t = 1.83, t = 0. 88, P 0. 05). Conclusion Conventional MRI is able to quantify the brain maturation and prognosis of premature infants using TMS.

Objective To study of relationship between elderly people's alexithymia and mind-reading. Methods There were 108 old people over 70 years old, tested by mind-reading,cognitive ability and twenty-item Toronto alexithymia scale. Results There were significant difference in mind-reading(16.00±4.84, 19.36±2.91,t =3.38,P ＜0.01), memory span(5.80±1.42,7.18±1.13,t =4.28,P ＜0.01), working memory( t =4.05,P ＜0.01),processing speed( t =-4.80,P ＜0.01) between high and low alexithymia groups.Alexithymia scores were negatively related to the scores of mind-reading, memory span,working memory,processing speed,correlation coefficient was 0.227( P <0.05),-0.377( P <0.01),-0.334( P <0.01),-0.470( P <0.01),respectively. With mind-reading,cognitive processing and educational level as independent variables,with total scores, F1, F2, and F3 of TAS as dependent variable,respectively,the regression equation of total scores was significant( F =8.594,P ＜0.01), and the one of F1 was significant( F =8.796,P ＜0.01),but the one of F2( F =1.735,P ＞0.05) and F3( F =1.181,P ＞0.05) was not significant. Conclusion Elderly people's alexithymia is negatively related to mind-reading and several cognitive abilities. Mind-reading could affect emotional recognition, but not affect emotional description and export-oriented thinking.

OBJECTIVE To investigate the infection status and drug resistance of mycoplasma and chlamydia isolated from female genitourinary tract in order to provide reference for doctors′ reasonable use of medicine.METHODS The IST2 kit produced by Bio-Merieux was used to culture the mycoplasma strains and to do drug susceptibility test.The VEDALAB kit was used to detect chlamydia.RESULTS Among 376 suspected patients with nongonococcal urethritis(NGU),the number of the patients infected by Ureaplasma urealyticum(Uu),mixed strains of Uu and Mycoplasma hominis(Mh),and Chlamydia trachomatis(Ct) were 216,35 and 125,respectively.The positive rate was 57.4%,9.3% and 33.3%,respctively.The drug susceptibility test showed that drug resistance rates of the other six antibiotics in mixed infection of Uu and Mh were higher than that in simple infection of Uu except for josamycin,ofloxacin and doxycycline.The sensitivity of doxycycline,josamycin and platenomycin in mycoplasma was the most highest.CONCLUSIONS Infection in female genitourinary tract is mainly due to Uu.We should reasonably choose and use antibiotics according to drug susceptibility.

Objective To determine the contents of lutein,zeaxanthin and ?-carotene in 31 vegetables.Method High performance liquid chromatography method with Develosil C30 column and ultraviolet detector was used to detect lutein,zeaxanthin and ?-carotene at wavelength of 480nm.A gradient elution method with elution A (acetonitrile:methol=75:25) and B (methyl-tert-butyl-ether) was used to separate the carotenoids in both raw and cooked vegetables.Results The retention time of lutein,zeaxanthin and ?-carotene was 10.355,10.732 and 20.789 min respectively.The contents of lutein,zeaxanthin and ?-carotene were linearly related with the peak area.Analysis showed that dark leafy vegetable such as amaranth,Chinese celery leaf,parsley,spinach and pakchoi petiole contained the highest amount of lutein.Zeaxanthin was detected only in dehydrated daylily.There was little or no loss of lutein,zeaxanthin and ?-carotene but an average increase in lutein and ?-carotene in vegetables after cooking.Conclusion Vegetables,especially dark leafy vegetables are major sources of dietary lutein,and ?-carotene.Consuming cooked vegetables tends to increase the intakes of lutein,zeaxanthin and their bioavailability.

Objective To investigate the receptor involved in the TNF?induced HO-1 expression and the related signal transduction mechanisms in the brain microvessel endothelial cells.Methods TNF? receptor 1(TNFR1)knockout murine brain microvessel endothelial cells(BMVECs)in vitro culture were stimulated respectively by TNF?(5ng/ml).After 24 hours,the level of HO-1 gene mRNA were detected by semi-quantitative RT-PCR,the effect of TNF?on JNK 、ERK or transcription factor AP-1 were analyzed by Western blot,while ERK inhibitor(PD98059)or JNK inhibitor(SP600125)were used.Results Exposure of wild-type BMVECs and TNFR1(p55)knockout BMVECs [BVEC/TNF-RI(-/-)] to TNF?(5ng/ml,24 h)caused a marked increase in HO-1 mRNA expression.Furthermore,TNF? stimulation also lead to the activation of JNK,ERK and the transcription factor AP-1 in the BVEC/TNF-RI(-/-),However,incubation with the JNK inhibitor SP600125 but not the ERK inhibitor PD98095 attenuated the TNF?-induction of HO-1 in the BVEC/TNF-RI(-/-).Conclusions TNFR2 and JNK activation but not TNFR1 might be essential for mediating the TNF?-induction of the HO-1 in the endothelial cells.