1.Predictive value of cord blood bilirubin level for subsequent neonatal hyperbilirubinemia in ABO hemolytic term infants
Chinese Journal of Perinatal Medicine 2015;18(1):20-23
Objective To evaluate the predictive value of cord blood bilirubin levels for subsequent neonatal hyperbilirubinemia in term infants with ABO hemolytic disease.Methods A total of 292 term newborns with ABO hemolytic disease admitted from August 1,2011 to July 31,2012 were enrolled.Cord blood bilirubin levels were analyzed and the clinical characteristics of the neonatal hyperbilirubinemia group (n=34) and non-hyperbilirubinemia group (n=258) were compared.A receiver operating characteristic (ROC) curve analysis was performed to identify the predictive value of the occurrence and cut-off point of hyperbilirubinemia in term infants with ABO hemolytic disease.Paired-t-test,Chi-square test and Spearman correlation were used for statistical analysis.Results Of the 292 term infants with ABO hemolytic disease,34 cases had hyperbilirubinemia,with an incidence of 11.6%.Cord blood bilirubin levels were significantly associated with the presence of hyperbilirubinemia.The mean cord blood bilirubin level in infants who developed hyperbilirubinemia was (52.4± 13.2) μ mol/L,and was (35.0±8.0) μ mol/L for those who did not develop hyperbilirubinemia (t=7.540,P=-0.001).When cord blood bilirubin concentration increased,the incidence of hyperbilirubinemia gradually increased (x2=113.715,P<0.001; rs=7.19,P<0.001).The ROC area under the curve of 0.882 (standard error 0.005,95%CI:0.873-0.891,P<0.001) was significant in predicting neonatal hyperbilirubinemia by cord blood bilirubin,and the occurrence of hyperbilirubinemia increased with increasing cord blood bilirubin level.Neonatal cord blood total bilirubin ≥ 50 μ mol/L predicted hyperbilirubinemia,and the positive predictive value was 0.683,negative predictive value was 0.959,sensitivity was 0.690 and specificity was 0.958.Conclusions Cord blood bilirubin level is useful in predicting subsequent neonatal hyperbilirubinemia in term infants with ABO hemolytic disease.
2.The effects of two-suppression therapy compared for school-age children with monocular amblyopia
Chinese Journal of Postgraduates of Medicine 2009;32(12):10-12
Objective To compare the effectiveness of two-suppression therapy with over-plus hyperopia lens and atropine mydriasis for school-age chihtren with monocular amblyopia. Method One hundred and sixty-seven cases of children with monocular amblyopia in the age of 7-12 years old were observed, who were randomly divided into two groups, using over-plus hyperopia lens or atropine mydriasis to suppress the normal eye, and the amblyopia eye was comprehensive trained, followed-up of 3 years. Results The effect rate was similar between over-plus hyperopia lens and atropine mydriasis [90.7%(78/86) and 91.4%(74/81), respectively]. There was no significant difference (P>0.05). Conclusions For school-age children with monocular amblyopia, you can use over-plus hyperopia lens inhibit the normal eye sight, its effect is similar with the atropine mydriasis.
3.Way of DIB Derived from DICOM Medical Image File
Chinese Journal of Medical Physics 2009;26(6):1500-1503,1512
Objective: According to clinical investigation, analysis on the storage format of DICOM3.0 medical images files and displaying them is the basis of medical image processing. It is very important for medical imaging technology. Methods: Firstly, with the DICOM standard, the format of the medical images is studied, mostly the format of the information header and data element. Then the DIB display of the DICOM images in Windows platform is put forward, using linear window-transformation. Results: It is successfully realized the display of CT、MR images. With the manual window-transformation, the displaying would be better. Conclusion: As the results show, the method studied in the paper can preferably realize the display of the DICOM medical images, meeting certain clinical needs, and laying a foundation for the following study.
4.The role of p38MAPK transduction system in chronic bronchitis
Xiaoming MENG ; Yan HUANG ; Jun LI
Chinese Pharmacological Bulletin 2003;0(07):-
Mitogen activated protein kinase(MAPK) is one of the four biggest signal transduction systems which contain four subtribes named p38,ERK5/BMK1,ERK and JNK/SAPKrespectively.Previous studies have shown that MAPK pathway is involved in growth,cell differentiation,perishing,the synchronization of cell function and so on.p38MAPK,one of the members of MAPK family,plays an important role in the activation of inflammation-related cells to release inflammation mediator,modulating enzyme production as well as transferring factors activity in the process of chronic bronchitis(CB).This review focuses on multiple roles of p38MAPK in the pathogenesis and progression of CB.
5.Study on the Antidepressant Effects and Mechanism of Hypericum Perforatum L.(EHP)in Stress-induced Depressive Model
Xiaoming ZHONG ; Qingqiu MAO ; Zhen HUANG
Journal of Zhejiang Chinese Medical University 2006;0(02):-
[Objective]To study the antidepressant effects and mechanism of Hypericum peratum L.(Elqe).[Methods]Forced-swimming test in mice,tail-suspension test in mice mensurating cerebracontents of monoamine neurotransmitters in chronic stress-induced depressive rats done to study the antidepressant effects and mechanism of extract of Hypericum peratum L [Results]Immobility time of forced-swimming and tail-suspension in mice which were significantly shortened by EHP (320mg/kg,160mg/kg)(P
6.An immunohistochemical and ultrastructural study on skeletal myodystrophy
Xiaoming JIN ; Zhijiu ZHONG ; Qi HUANG
Journal of Clinical Neurology 2001;0(05):-
Objective To study the relationship between pathological, immunohistochemical and ultrastructural changes of skeletal myodystrophy (SMD) and the development of the disease.Methods SMD tissue of 20 cases were routinely processed,the paraffin sections,the semi thin sections and the ultrasthin sections were observed by light microscopy and electron microscopy.Results 20 cases with SMD tissue were divided into three groups: Simple SMD for 8 cases, major changes were regional; Progressive SMD for 10 ca ses, the pathological changes were diffuse with large amount of degeneration of cell organs; SMD derived from nerve injury for 2 cases, pathological changes of the part controlled by the nerve were observed. While SMD was injured, myosin got deneration first.Conclusion The pathological and ultrastructure changes could be used to judge the progressive degree of myodystrophin. The amount of lost myosin could forecast the progression of the disease.
7.The latest development of artificial vision technology
Hujun ZHANG ; Xiaoming HUANG ; Jianwen GU
Chinese Medical Equipment Journal 1989;0(01):-
The latest domestic and foreign development of artificial vision technology is introduced in this paper. Its prospect and feasibility in China are mentioned too.
8.The design of the network database of tele-monitoring system
Bangyu HUANG ; Xiaoming WU ; Yanfang LIU
Chinese Medical Equipment Journal 1989;0(04):-
As an important component of multi-physiological-parameter tele-monitoring system, database system is characterized by its large capacity, complex data type and being realtime. According to the design flow of the database, this paper develops a multi-physiological parameter network database with EER concept model and distributed database technology.
9.The Application of Fat-suppressed Spoiled Gradient-Echo (3D-FS-SPGR) Sequence in Association withThree-Dimensional Reconstruction in Cartilage Disorder of Knee
Sirun LIU ; Xiaoming LENG ; Li HUANG
Journal of Practical Radiology 1992;0(11):-
Objective To evaluate the clinical value of 3D-FS-SPGR and 3D-reconstructional technique in detecting the lesion of articular cartilage of knee.Methods Fifty eight knees with OA(42 cases)or trauma (9 cases) in 54 cases (12 cases were confirmed by operation) were imaged with eight different MR imaging sequences including T 1-weighted,proton density-weighted,T 2-weighted FSE,STIR,3D-FS-SPGR,2D-FS-SPGR,3D-SPGR and 3D-FS-GRE.The classification and three-dimensional reconstruction of cartilage in four locations of knee were performed on different MR sequences.The detecting rate of cartilage lesion were calculated.The results in partly cases were analysed compared to operation. Results The detecting rate was different on each sequence as follow:T 1WI,GRE,STIR,PDWI,T 2WI and SPGR were 8.91%,16.36%,19.32%,19.57%,21.36% and 24.09% respectively (? 2=23.523,?
10.Study of microsurgical anatomy and multi-slice helical CT scanning of cochlear aqueduct
Chunlei LU ; Chunlin HUANG ; Xiaoming QI
Medical Journal of Chinese People's Liberation Army 1983;0(02):-
Objective To obtain more detailed microsurgical anatomical data and multi-slice helical CT scanning of cochlear aqueduct for the translabyrithine approach. Methods Twenty cadaver heads(40 sides)fixed with formalin were dissected under a microscope ,and cochlear aqueducts were found and measured. Five cadaver heads(10 sides) were scanned by multi-slice helical CT. Results The width of external aperture of cochlear aqueduct was (2.64?0.82)mm. The length of cochlear aqueduct was (8.40?1.35)mm. The distance between cochlear aqueduct and cranial nerves Ⅸ, Ⅹ, Ⅺ, and that between the inferior petrosal sinus was(1.08?0.36 )mm,(2.71?0.63)mm,(4.52?1.25)mm, (1.14?0.46)mm, respectively. The distance between external aperture of cochlear aqueduct and the inferior margin of internal acoustic meatus aperture was (5.53?0.93)mm. The otic capsule segment of cochlear aqueduct could not be demonstrated on the coronal section. The petrosal portion could be demonstrated by both coronal and axial scannings. Conclusion The axial scanning was useful for detecting cochlear aqueduct. Cochlear aqueduct could be regarded as one of the landmarks in translabyrithine approach for cerebellopontile angle operation.