Embodied as an abstract concept as well as concrete regulations and material environment on the campus,the campus culture is the organizational culture among universities,which plays a significant role in enhancing students' quality of career starting.Similar to its social culture,the American campus culture is characterized by a strong personal heroism thus is known as a "cowboy culture".As the so-called "dragon culture",the Chinese culture is a more conservative one and thus lack of innovation-oriented career starting concepts among Chinese university students.Therefore,in order to effectively carry out entrepreneurship education in colleges and universities,the innovation-oriented campus culture should be constructed,students' entrepreneurship conception strengthened,thus students' sense of career starting and mental status be enhanced.

Programmed cell death-1 (PD-1), as a member of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), is ex-pressed on the membrane of activated T cells , B cells and macrophages.Combining with programmed cell death-ligand 1 (PD-L1), PD-1 will inhibit the proliferation of T cells and further involve in T cell receptor signaling negative feedback regulation .As the signifi-cant relationship between PD-1 /PD-L1 expression and prognosis in tumor cells , monocytes and T cells of ovarian cancer patients , this review focuses on the biological significance , influencing factors , advances of related drugs and clinical application of PD-1 /PD-L1 in ovarian cancer .

This paper discussed the ethical principles in the medical sci-tech journal editing work, namely, respect, fairness, equality, honesty, and combining with the particularity of medical journals, further discussed these principles during choosing manuscripts, inviting manuscripts, peer review, rejection, and so forth. This pa-per proposed that medical journal editors should adhere to in the work of ethical principles, and constantly improve their ethics quality.

Objective To investigate the therapeutic effects of Astragalus & Angelica (A&A) , the mixture of Chinese herbs, on different vasoconstrictors and vasodilators in the process of renal interstitial fibrosis in rats with unilateral ureteral obstruction (UUO). Methods Wistar rats were randomly divided into Sham,UUO and UAA (UUO+A&A) groups. After administration of A&A (14 g?kg-1?d-1) for 0, 3, 7 and 10 days, the levels of Ang-II , ET-1, nitric oxide(NO) and the activities of different NOS in renal homogenate were measured by RIA or enzyme method. The expression levels of eNOS, nNOS, iNOS were detected in the kidney by immunohistochemistry and semi-quantitively assessed by Western blot. Results After A&A administration, the levels of Ang- II and ET-1 were increased in UUO at all time points (P

Aim The mixture of Chinese herbs,Astragalus & Angelica(A&A) has been found that has antifibrotic effect in rats.Methods To elucidate themechanisms underlying the renoprotective effects of A&A in the process of renal interstitial fibrosis,we investigated the pathology changes of kidneys in unilateral ureteral obstruction(UUO) rats.In the study,Wistar rats were randomly divided into CON,Sham,UUO and UUA(UUO+A&A) groups.After administration of A&A(12 g?kg?d~(-1)) for 0,3,7 and 10 d,renal damage including interstitial cell infiltration,tubular atrophy and interstitial fibrosis were quantified on HE and Masson stained tissue sections.The expression of ?-smooth muscle actin(?-SMA),transforming growth factor-?_1(TGF-?_1) and fibronectin(FN) was measured using computer image analysis of immunohistochemistry staining sections,ELISA and Western Blot.Results Renal damage and the expression of ?-SMA,TGF-?_1 and FN were all significantly exacerbated in UUO group compared with those of Sham group(P

Aim To research the effects of HSP70 in-hibitor ( PFTμ) on the expressions of iNOS induced by IFN-γ in RAW 264. 7 cells. Methods The NO con-centration was measured by Griess Kit. The expression of interest protein was measured by Western blot and iNOS mRNA was measured by RT-PCR. Mouse cardi-ac ischemia-reperfusion ( I/R ) model was established to set up the inflammatory response. These were divid-ed into control and treated groups. The infarct size was monitored on myocardial I/R mice. Results We found that PFTμsignificantly blocked the production of NO and the expression of iNOS protein and mRNA in RAW 264. 7 cells. The mechanism may be part of the inhibition of nuclear IRF-1 protein expression. We also found that PFTμ reduced the infarct size in myocardial I/R mice ( P <0. 05 ) . Conclusion These results suggest that PFTμ down-regulates the IFN-γ-induced iNOS transcription through decreasing translocated IRF-1 protein.

Objective: To investigate the preventive and theraputic effects of Astragalus and Angelica mixture(A&A)on renal tubulointerstitial fibrosis after unilateral ureteral obstruction(UUO)in rats and their mechanisms. Methods: UUO rats were randomly divided into Sham, UUO, A&A or ACEI groups. A&A, ACEI or the same amount of water was administered by gavage beginning 24 hours before UUO preparation and continued through ten days after UUO. Sera and the kidney tissues were collected from each group on the tenth day. Scr and BUN were measured. Trichrome staining, measurement of tubulo interstitial damage index and immunohistochemical studies localizing ? smooth muscle actin(? SMA), TGF ? 1, fibronectin(FN), laminin(LN)were carried out. Results: In UUO rats, the tubular interstitial damage index, the expressions of ? SMA, TGF ? 1, FN and LN were all increased compared with those of Sham group. The tubulo interstitial damage index had positive correlation with expressions of ? SMA, TGF ? 1, FN and LN. A&A significantly ameliorated deterioration of renal function, tubulo interstitial damage index and inhibited the over expressions of ? SMA, TGF ? 1, FN and LN in UUO rats. These anti fibrotic effects were similar to those affected by ACEI. Conclusion: In renal interstitial fibrosis induced UUO rats, A&A retard the progression of renal fibrosis and renal function deterioration by inhibiting myofibroblasts and suppressing TGF ? 1 expression, which may consequently result in a decreased production of extracellular matrix.

Olympic volunteer spirit is a valuable spiritual treasure of Beijing Olympics.It is of great significance for enhancing the devotion consciousness of current college students and stimulating their innovative competence to take full advantage of the social educating function of Olympic volunteer spirit.Meanwhile,the Olympic volunteer spirit is also a major carrier of CPC construction and the cultivation of Party members among college students.

Objective To observe the changes of tissue doppler Tei index (TDI-Tei index) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in children with atrial septal defect(ASD) before and after interventional therapy,in order to investigate the evaluation value of the two parameters on the improvements of right cardiac function.Methods Ninety children with ASD who were treated in the First Hospital of Hebei Medical University from June 2013 to June 2015 as the ASD group,including 48 male and 42 female at the age of (3.0-13.0) years old,and the average age was (5.4±2.7) years old.Fifty healthy children with matched age and gender as the control group.Concentrations of serum NT-proBNP were measured by using Bi-directional lateral flow immunoassay before and the 7th day and 6th month after cardiac catheterization,respectively.The right ventricular Tei index(RV-Tei index) was measured by tissue doppler Imaging.The changes and the correlations of parameters before and after interventional therapy were compared and analyzed respectively.Results (1) Before interventional therapy,the right ventricular TDI-Tei index in ASD group was higher than control group(0.56±0.09 vs 0.31 ±0.05,P＜0.01),and the TDI-Tei index was decreased gradually at different time points after interventional therapy in ASD group,especially at the 6th month was lowest(P＜0.01);TDI-Tei indexes at before and the 7th day and 6th month after the procedure were significantly different(0.56±0.09 vs 0.44±0.06,0.56±0.09 vs 0.33±0.04;t=22.56,23.27;P＜0.05).Compared with control group,there was significant difference about the TDI-Tei index in ASD group at the 7th day after transcatheter closure(P＜0.05),while there was no significant difference about TDI-Tei index at the 6th month (P＞0.05).(2) Before interventional therapy,the level of serum NT-proBNP in ASD group was higher than control group ((259.49± 43.99) ng/L vs (102.11 ± 34.53) ng/L,P＜0.01),and the levels of NT-proBNP were decreased gradually at different time points after interventional therapy in ASD group,especially at the 6th month was lowest(P＜0.01);the levels of NT-proBNP at before and the 7th day and 6th month after interventional therapy were significantly different ((259.49 ± 43.99) ng/L vs (192.93 ± 56.46) ng/L,(259.49±43.99) ng/L vs (108.46±36.88) ng/L;P＜0.05).Compared with control group,there was significant difference about the level of serum NT-proBNP in ASD group at the 7th day after transcatheter closure (P ＜0.05),while there was no significant difference about NT-proBNP at the 6th month(P＞0.05).(3) Before and the 7th day and 6th month after interventional therapy,NT-proBNP level and the right ventricular TDI-Tei index was significantly positive correlated in ASD group (r =0.719,0.753,0.732;P＜0.01).Conclusion The changes and correlations of the right ventricular TDI-Tei index and serum NT-proBNP in the children with ASD after intervention operation indicates that TDI-Tei index and serum NT-proBNP could evaluate the improvement of right cardiac function.

Objective:To explore whether Chinese herbs Astragalus and Angelica mixture(A&A) have renoprotective effects on chronic renal failure in rats.Methods:5/6 nephrectomized kidney in rats was used as chronic renal failure model.Rats were randomly divided into four groups which included sham,Model,A&A and enalapril(Ena) groups.The remnant kidney was harvested after 2,4,8,12 weeks,and levels of serum creatinine(scr),urea and urinary protein excretion were measured using routine biochemical methods.The pathological lesions were observed by light microscope.The expressions of fibronectin(FN) and collagen Ⅳ(Col-Ⅳ) in glomeruli and interstitium were detected by immnuohistochemistry.Results:5/6 nephrectomized rats were presented with the characteristics of increasing scr and urea,persistent proteinuria at the end of the 2nd,4th,8th,12th weeks,respectively.They had increasing size of glomeruli with progressive proliferation of mesangial cells and mesangial matrix followed by glomerulosclerosis and progressive elevated expressions of FN and Col-Ⅳ.Compared with Model group,the administration of A&A could decrease urinary protein excretion for 34%,44%,25%,45% at the end of the 2nd,4th,8th and 12th weeks,respectively(P