Objective To explore the preventive and protective effect of CGRP on focal cerebral infarction in rats.Methods Focal cerebral infarction model was made by photochemical reaction. The level of cerebral edema was assayed by measuring brain water content.Nervous system evaluation was scored by the method of Ohno, Bederson, LeWay standard. The volume of cerebral infarction and its location were determined by TTC staining.Results CGRP has significant preventive and protective effect to focal cerebral infarction which showed the nervous system scores took a favourable turn, brain edema descended and infarction volume reduced. This effect was related with the dose and the way of administration of CGRP. A single dose (1.33 BU/gBW) of CGRP didn't have significantly effective.It should be given for at least over 2 days. This protective effect did not increase when the dose increased to a certain level. As for the effect of the way of administration of CGRP, multiadministration of fewer doses CGRP was better while the total dose kept constantly.Conclusion CGRP has definite preventive and protective effect to focal cerebral infarction in rats.It has also better effective in inhibition of brain edema. However its dose should be confined in a proper level.

Objective To analyze the clinical features of lobar hemorrhage and the differences in etiology,clinical manifestation and prognosis between young,middle-aged and aged patients.MethodsSix hundred and twenty patients with spontaneous intracranial hemorrhage (ICH) were consecutively admitted to our hospital.The following data were recorded:gender,age,risk factors,cause of disease,symptoms at the early stage,Glasgow coma score (GCS) and Neurological deficit scale (NDS),bleeding part and amount,complications during hospital stay and outcome.Patients were divided into lobar hemorrhage group (n=73) and non-lobar hemorrhage group (n=547),and compared with each other on the parameters mentioned above.Patients with lobar hemorrhage were subdivided into young and middle-aged subgroup (

BACKGROUND: Gong's nonverbal intelligence test(GNIT) is a nonverbal and cross-cultural test of intelligence designed primarily to suit the use in the minority groups and those with linguistic difficulties by Professor Gong Yao-xian. At present 5 unified norms of the minority groups as well as norms of Chinese Han children and adult aged below 55 years have been developed, but the norms for the elderly above 56 years of age are not available. Nonverbal intelligence test is especially suitable for the elderly and has therefore wide applications.OBJECTIVE: To establish regional norms of the GNIT for healthy elderly people above 56 to enable the completion of nonverbal intelligence test norms suitable for each age groups.DESIGN: A controlled study with stratified sampling of healthy elderly retirees over 56 years of age in the community.SETTING: Department of Physiology in Medical College of Henan University of Science and Technology; Center for Psychology, Xiangya Second Hospital,Central South University.PARTICIPANTS: Healthy elderly retirees above 56 years of age in Luoyang cityor the counties were selected on a voluntary basis with stratified sampling according to the proportion of each region. The selected subjects aged between 56 and 101 years, and 8 age groups were divided at the interval of 5 years(about 200 people in each age group). Totally 1 460 subjects were selected, including 679 male and 781 female subjects.METHODS: With the instruments and manual of GNIT, the subjects were tested for color identification, classification, blank-filling with numbers or graphs, characters and encoding tests. The results were original scores, scale scores and intelligence quotient.MAIN OUTCOME MEASURES: The norms of GNIT for the elderly above 56 years of age.RESULTS: The norms included three scores, namely the original scores, scale scores and standard deviation scores. To test of reliability and validity of the norms, retest was performed in 40 1 or 2 weeks after the initial test, resulting in the test-retest reliability coefficient ranging from 0.59 to 0. 89, with the total test-retest reliability coefficient of 0.83. The correlation coefficients the original scores between the subtests ranged from 0. 35 to 0. 63, and the correlation coefficients between the standard deviation scores of the verbal intelligence quotient(VIQ), performance intelligence quotient(PIQ) and full intelligence quotient(FIQ) of Wechster intelligence scale for children(WAIC-RC) were 0.43,0.51 and 0.54 respectiyely, based on a study of a sample of 50 elderly subjects.CONCLUSION: Primary regional norms of GNIT for elderly subjects above 56 years of age have been established to measure mainly the perception and reasoning factors loaded with also visual motor psychological factors and abstract summary factors, with satisfactory reliability and validity equivalent to similar tests.