Objective To explore the effects of Qiuxieling associate with Licorzinc therapy on infantile rotavirus enteritis. Methods Infants with rotavirus enteritis were divided into 4 groups (symptomatic and supportive treatment group,Licorzinc group,Qiuxieling group,and Qiuxieling combined with Licorzinc group).The curative effect was analyzed.Results The total ef-fective rates of symptomatic and supportive treatment group,Licorzinc group,Qiuxieling group,and Qiuxieling combined with Licorzinc group were 77.5%,82.5%,85.0% and 92.5%.The average disease courses of symptomatic and supportive treatment group,Licorzinc group,Qiuxieling group,and Qiuxieling combined with Licorzinc group were (6.44 ± 0.79 ),(5.82 ± 0.55 ), (5.66±0.50)and (4.78 ±0.50)days.The curative effects were significantly higher in Qiuxieling combined with Licorzinc group compared to symptomatic and supportive treatment group,Licorzinc group and Qiuxieling group (P <0.05).Conclusion Qiuxiel-ing and Licorzinc were significantly effective in the treatment of infantile rotavirus diarrhea,and can short the disease course.

AIM: To observe the difference in the application of proportion of pinellisa decoction for purging stomach-fire, ginger rind and licorice root with different BP (back propagation,BP) method of artificial neural network. METHODS: The influence of gastric mucuqas content in normal rats was measured, and the groups of different flavor of a drug and dosage were divided according to homogeneous design. This research was programmed with MATLAB6.5, conformed the experimental data with BP artificial neural network, and the research compared the different structural topology of 8-3-1?8-8-1?8-12-1, and compared the different influence with the different BP method to network. And then, the expected mode of gastric mucus content was formed, which based on the BP neural network. RESULTS: The artificial neural network model that had 8-10-1 structural topology and improved BP method was formed, and it was a kind of good method to uniform the studied samples and to forecast the unstudied samples, Moreover, the expected effect of variable learning rate back propagation was best. CONCLUSION: Using the studying of pinellisa decoction for purging stomach-fire, ginger rind and licorice as an example, and give birth to the new model in studying proportioning of compound prescription. This model will found its position in studying proportioning of compound prescription.

Objective To observe the structure changes of the synapse of the neurons in hippocampus CA3 of young rats and study the basis for the mechanism of polyene phosphatidyl in providing learning and memory and the effect on synaptic plasticity.Methods A total of 20 Wistar rats with 5 months were randomly divided into polyene phosphatidyl group and normal control group.Each group had 10 rats.After 4 weeks feeding,Water maze training was peformed in all the rats for 1 weeks.The immue expressions of synapsin(SYN) of the rats in polyene phosphatidyl group and control groups were observed with immunohistochemical method and analyzed by MOTAC imagine analyzing system.The change of synapse of hippocamal CA3 was observed with electron microscope.And the other 24 to 26 months rats were selected as aged group,and fed in the same condition.Moreover,the ultrastructures of hippocamal CA3 of aged rats were observed by transmission electron microscopy(TEM).Results The SYN in polyene phosphatidyl group(0.430 0?0.022 4) was higher than that in control group(0.3567?0.0209) (P

The development of the minimally invasive targeted ablation tendency creates a new therapy for lung cancer. This treatment is featured with considerably extensive indication ,excellent local control and survival time, low incidence and controllable complications. There are many strong proofs of clinical efficacy and safety in this field presently.

Objective To analyze factors affecting quality of life (QOL)in patients with chronic hepatitis B (CHB),and provide reference for improving QOL of patients. Methods The MOS 36-item short form health sur-vey (SF-36)was adopted to survey QOL of patients with CHB,Morisky medication adherence scale was used to measure patients'adherence to medication,factors affecting QOL of patients with CHB were analyzed. Results Of 357 CHB patients,271(75.91% )were married,107(29.97% )received college or above education,163(45.66% ) patients'average household monthly income were ￥ 2000-￥ 5000,138(38.66% )patients'family members were also with CHB,198 (55.46% )patients smoked,150 (42.02% )drank. The average score of CHB patients' adherence to medication was (2.15±1.29). Factors affecting QOL in patients with CHB were age,education level, duration of disease,whether or not hospitalized,whether or not drink,as well as adherence to medication. Age, drink,and duration of hepatitis B,and previous hospitalization were negative factors affecting QOL in patients with CHB,education level and adherence to medication were positive factors affecting QOL in patients with CHB. Conclusion Strengthening CHB patients'understanding on disease and improving their medication adherence can help them to improve QOL.

OBJECTIVE:To provide reference for the understanding of quality status of Insulin injection and improvement of related standards. METHODS:The statutory methods of Insulin injection were adopted to test 32 batches of samples(including ap-pearance,identification,capacity,visible foreign matter,sterility and potency determination of biological method). Consulting specification of other similar products,RP-HPLC was conducted to determine the related impurities,content and phenol in sam-ples;HPSEC was conducted to determine the high molecular weight proteins and atomic absorption spectrophotometry was conduct-ed to determine the Zn content. RESULTS:Results of all the 32 batches of samples were qualified by the test of statutory methods. According to the method of other similar products,the determination result of A21 desamido insulin was 15.6%-39.2% and general-ly greater than 5.0%, which was the highest limit of similar products;insulin was 93.2%-102.7%;protein polymer was 0.5%-0.6%;phenol was 2.34-2.51 mg/ml and Zn was 12.3-14.8 μg/100 U. CONCLUSIONS:The statutory specification of Insulin injection is short of many key specification items such as impurities and content determination;the contents of protein polymer, phenol and Zn were in good control;the contents of A21 desamido insulin are generally high,and stability of insulin main peak is relatively poor.

Malignancies threaten human health seriously.Recently studies show that intercellular signal transduction influences the biological characteristics of tumor cells.It has closely relationship with tumor growth and metastasis.Insulin-like growth factor ( IGFs ) signal transduction system is a potential mitogen that distributed in the body′s tissues, organs and blood.Researches show that the abnormal expression of IGFs exists in many tissues, such as breast cancer, colorectal cancer, gastric carcinoma, lung carcinoma, pancreatic cancer and so on, which may play an important role in occurrence and metastasis as a novel tumor marker.

0.05)in visual analogue scales and blood-gas results,but the respiratory recovery function in ropivacaine group was markedly better than that in the bupivacaine group(P

AIM: To study the role of p38 mitogen-activated protein kinase (p38MAPK) activation in high glucose-induced collagen Ⅲ synthesis in NRK52E cells. METHODS: Normal rat tubular epithelial cell line NRK52E was cultured in D-glucose of different concentrations, pretreated with SB203580 and collected at different time points. The levels of phospho-p38MAPK and extracellular matrix collagen Ⅲ were examined by Western blotting. RESULTS: The activation of p38MAPK was shown to be dependent upon D-glucose concentration and the time-course. Pretreatment with SB203580 blocked p38MAPK activation induced by high concentration of D-glucose in NRK52E cells. CONCLUSIONS: The activation of p38MAPK induced by high concentration of glucose may play a role in diabetic interstital renal fibrosis. SB203580 has a potential value of clinical applications in the prevention and treatment of diabetic nephropathy.

Objective To discuss the clinical effect of normal saline flushing and heparinized saline flushing in invasive arterial blood pressure monitoring in the critical patients. Methods A total of 140 critical patients were randomly divided into the experimental group and the control group with 70 cases in each group according to the envelope method. The experimental group used normal saline for tube flushing, the control group used heparinized saline (5 U/ml) for tube flushing. The incidence of complications and coagulation index were compared between two groups. Results There was no statistically difference in the incidence of the catheter jam and local infection (P>0.05). The incidence of bleeding events was 14.3% (10/70) in the control group, which was higher than 2.9% (2/70) of the experimental group. The difference was statistically significant(χ2=4.466, P<0.05). The activated partial thromboplastin time, prothrombin time of the control group were (32.22 ± 4.22) s, (11.56 ± 2.12) s, which were longer than (29.84 ± 3.64) s, (10.66 ± 1.48) s of the experimental group. And international normalized ratio of the control group was 1.12±0.14, which was higher than 1.03±0.20 of the experimental group. The difference was statistically significant (t values were-3.573,-2.912,-3.084, P <0.05). Conclusions The normal saline flushing liquid was more safer and reliable in the invasive arterial blood pressure monitoring.