Problems in pathology teaching requires the introduction of PBL pedagogy.Teaching experiments show that PBL teaching has a positive impact on the improvement of clinical medical students'ability and quality and can be conditionally applied and promoted. And at the same time, it is a challenge to traditional teaching mode of pathology and therefore the reform of medical education needs to be deepened.

Implementing PBL teaching in the political theory course,making sure the scientific nature of the problem setting are the fundamental guarantees of the right track of political theory education.There are several specific approaches to implement the PBL teaching effectively:leading up to the problem when teacheing in the large class; completing the analysis and research by dividing groups; carrying out class discussions by teams; submitting discussion experiences by each student.Practice has proved that,PBL teaching is better than LBL one.

Objective To observe endothelial and fibrinolytic functions of clinical AF patients and effects of cilazapril on it and to investigate the mechanism and treatments of thrombogenesis in AF.Methods 63 AF patients were randomly divided into control group(n=30)and cilazapril group(n=33).All patients received general treatment according symptoms.In addition,the patients in cilazapril group received cilazapril(2.5mg/d,2 weeks).Plasma Ang Ⅱ, vWF,t-PA and PAI-1 level were measured before and after 2 weeks.There were 36 patients with sinus rhythm (SH)in non-AF control group.Results AF patients had higher plasma Angll level than SH patients that indicated RAS activated[(107.7?22.0)pg/mL vs(70.2?15.8)pg/mL,P

Objective To observe endothelial and fibfinolytic functions of clinical AF patients and effects of cilazapril on it and to investigate the mechanism and treatments of thrombogenesis in AF.Methods 63 AF patients were randomly di- vided into control group (n=30) and cilazapril group (n=33).All patients received general treatment according symptoms.In addition,the patients in cilazapril group received cilazapril (2.5mg/d,2 weeks).Plasma Ang Ⅱ, vWF,t-PA and PAI-1 level were measured before and after 2 weeks.There were 36 patients with sinus rhythm (SH) in non-AF control group.Results AF patients had higher plasma AnglI level than SH patients that indicated RAS acti- vated[(107.7?22.0) ng/L vs (70.2?15.8) ng/L,P

Radical trachelectomy (RT) is known as a developing sign of the surgical treatment of cervical cancer in the 21st century.RT brings hope for the patients with early cervical cancer who eager to retain their fertilities.The extent of surgery include RT and pelvic lymphadenectomy.The major methods of radical trachelectomy include abdominal (RAT) and vaginal (RVT) approaches.The efficacy and feasibility of RT is similar with standard treatment,which has great application value in clinical.

Objective To investigate the level of urinary TGF-β1 and evaluate its clinical significance in patients with chronic nephritis.Methods 22 healthy people and 40 patients with chronic nephritis were selected,the levels of urinary TGF-β1 were measured by RT-PCR and ELISA.Results Urinary TGF-β1 were significantly increased in Mesangial Proliferative Glomerulonephritis (76.44± 24.29 ng/mmol.Cr vs 31.53 ± 11.59 ng/mmol.Cr,P<0.01);Focal Glomerular Sclerosis (65.07±20.59 ng/mmol.Cr vs 31.53±11.59 ng/mmol.Cr,P<0.01)and IgA Nephritis (67.01±21.95 ng/mmol.Cr vs 31.53±11.59 ng/mmol.Cr,P<0.01),comparing with normal group.Conclusion The levels of urinary TGF-β1 could be a predictor in reflecting the sate of renal diease,estimating pathological type,diagnosing the renal diease and observing the therapeutic effects.

MTH1 enzyme belongs to the family of Nudix hydro-lases, which can prevent the oxidative damage of nucleic acid by cleaning up oxidized purine nucleotides .Close relationships were found between the activity of MTH 1 and neurodegenerative dis-eases, anti-aging et al.In recent years, MTH1 has been regar-ded as a new promising target for cancer treatment , because it plays an essential role in tumor growth , survival , invasion and metastasis.The transcription and translation , structure, catalyt-ic mechanism, detection and application of MTH1 were de-scribed, as well as various MTH1 inhibitors.

Aim: To develop marine microporous osmotic pump tablets and to investigate drug release in vitro of the optimized formulation and the release mechanism.Methods: Wet granulation and film-coating were used to develop marine micro-osmotic pump tablets.In vitro release studies were applied to evaluate the impacts of various factors on the release of the formulation.Central-composite design was exploited to aid the optimization of the formulation,and the mechanism of in vitro release was characterized.Results: There existed fairly good reproducibility in the preparation of marine micro-osmotic pump tablets.It was found that no change in the release rate of the tablets were elicited by the pH of the release media,the rotating speed selected,the hardness of the tablet core,and the amount of the plasticizer incorporated into the coating formulation.It was proved that the release of marine micro-osmotic pump tablets was closely related to the magnitudes of NaCl amount in the tablet core and the pore former in the coating formulation as well as the coating level.In addition,there existed 12-hr zero-order kinetics in the in vitro release study of the tablets.Moreover,it was shown that the osmotic pressure-controlled delivery is greatly responsi-ble for the release of the developed tablets.Conclusion: The prepared marine microporons osmotic pump tablets are expected to be a new sustained-release medication.

Proteomic research first came to the fore with the introduction of two-dimensional gel electrophoresis and proteomics has been increasingly applied to cancer research with the wide-spread introduction of mass spectrometry and protein chip.As important research tools,oncoproteomics that targets the entire cancer-specific protein network has already been applied in cancer research.In this article the development of the oncoproteomics and its applying in cancer is reviewed.

Objective To study the effective constituents from the stem bark of Erythrina variegata.Methods The compounds Ⅰ-Ⅸ were isolated by a combination of silica gel,Sephadex LH-20,and ODS chromatographies and their structures were identified by spectral methods.Results Nine known compounds were isolated from the stem bark of E.variegata.Their structures were identified by means of spectroscopic analysis as: 5,4′-dihydroxy-8-(3,3-dimethylally)-2″,2″-dimethylpyrano [5,6∶6,7] isoflavone(Ⅰ),stigmasterol(Ⅱ), erythrinasinate B(Ⅲ),3-hydroxy-2′,2′-dimethylpyrano [5,6∶9,10] pterocarpan(Ⅳ),5,7-dihydroxy-8-(3,3-dimethylally)-dihydroflavanone (Ⅴ),5,4′-dihydroxy-2″,2″-dimethylpyrano [5,6∶6,7] isoflavone(Ⅵ),5,7,4′-trihydroxy-6,8-di(3,3-dimethylally) isoflavone(Ⅶ),5,2′,4′-trihydroxy-8-(3,3-dimethylally)-2″,2″-dimethylpyrano [5,6∶6,7] isoflavone(Ⅷ),5,4′-dihydroxy-6-(3,3-dimethylally)-2″,2″-dimethylpyrano [5,6∶7,8] isoflavone(Ⅸ).Conclusion Compounds Ⅰ,Ⅲ,Ⅳ,Ⅶ,and Ⅸ are isolated from this plant for the first time and compound Ⅴ is newly isolated from the plant of Erythrina Linn.