Objective To evaluate the validity and reliability of social avoidance and distress scale (SAD) for conforming it' s applicability in Mongolian college students.Methods Social avoidance and distress scale (SAD)security scale (SQ),self-esteem scale (SES) and life satisfaction scale (AULC) was used to measure 399 undergraduates whose can understand Mongolian and Chinese language.Results The total scale reliability was 0.872,avoidance scale was 0.726,distress scale was 0.742,total scale heavy reliability (r) was 0.86,avoidance scale (r) was 0.789,distress scale (r) was 0.814.(2)the confirmatory factor analysis verified the effectiveness of the structure,the revised model fitting index x2/df=4.864,NFI =0.92,TLI =0.90,GFI =0.90,IFI =0.87,GFI =0.92,AGFI =0.93,RMSEA =0.06,model fitting was better.(3) There was a significant positive correlation between avoidance scale and distress scale (r=0.634,P＜0.01),and there was a negative correlation (r=0.202-0.499,P＜0.01) between avoidance scale and SES,SQ and AULC.There was a negative correlation between distress scale and SES,SQ and AULC (r=0.192-0.556,P＜0.01).Conclusion SAD (Chinese version) has a good reliability and validity in Mongolian college students.

As the products of modern science,the effects of video games on children and adolescents drew the attention of psychologists.Anderson and Bushman proposed the General Aggressive Model,which could explain both the development of aggressive behavior and the difference of individual vulnerability to the effects of violent video games,and they advocated the effects,including short-term effects and long-term effects.Many researches about the relation of violent video games and aggression reported five consistent results:exposure to violent video games increased aggressive behavior,cognition,affect and physiological arousal,and decreased helping behavior.The positive intervention of parents can decrease negative effects of video games.

Fecal microbiota transplantation(FMT),as a special organ transplantation,can be used to reconstruct the intestinal flora.It has been concerned by clinical practice,but it has not become a routine treatment method.With the gradual deepening of the study of FMT,the refractory difficile fusiform bacillus infection,inflammatory bowel disease,irritable bowel syndrome,chronic fatigue comprehensive syndrome and some metabolic disorders related to intestinal diseases were obtained using.In recent years,there are some reports about the application of FMT in children's diseases.Combining with the relevant literature at home and abroad,this paper reviews the indications and the taboo of the application of FMT in children,the aim is to provide a reference for FMT to be better applied in pediatric clinical.

Objective To investigate psychosocial distress status of hospitalized patients with nasopharyngeal carcinoma and then analyze its influencing factors.Methods Using the method of convenience sampling,the level of psychosocial distress of hospitalized patients with nasopharyngeal carcinoma was measured with psychosocial distress thermometer (DT),then by orderly classification Logistic regression analysis methods,the main factors affecting the degree of psychosocial distress were obtained.Results This study in cluded 235 patients,and 228 patients completed the survey effectively,DT score was (4.030±2.993) points,including DT ＜ 4 points (mild pain) accounted for 36.8％ (84/228),DT 4-6 points (moderate pain) accounted for 38.2％ (87/228),DT≥7 points (severe pain) accounted for 25.0％ (57/228).Regression analysis showed that the economic problems,emotional problems (depression,fear,sadness),body problems (eating,oral ulcer,sleep problems),age,education degree,stressful life events in the recent year,the time of disease diagnosis,and disease recurrence were the main factors influencing the degree of psychosocial distress.Conclusions Hospitalized patients with nasopharyngeal carcinoma have widespread psychosocial distress,clinical medical personnel should take individualized psychological evaluation and intervention according to the related factors of psychosocial distress in order to reduce the degree of psychosocial distress.

Objective:To study the fracture resistance of nanofilled composite resin restoration for the treatment of incisally fractured in-cisors. Methods:30 extracted permanent maxillary central incisors were randomly divided into A, B and C groups (n=10). In group A and B, the teeth were cut obliquely from the mesial incisal angle. Labial reduction of 0. 5 mm for veneer and dovetails in the lingual surfaces were prepared. In group A, additional 2mm of the incisal edge were cut horizontally. The teeth were restored with nanofilled com-posite resin. The samples in group C were unprepared as the controls. The specimens were stored in artificial saliva and underwent 2 000 cycles of thermal cycling test. Fracture resistance of the teeth was measured by a test machine and the fracture mode was observed. Re-sults:The mean fracture load(N) of group A, B and C was 466.93 ±171.68, 444.5 ±173.00 and 474.77 ±97.55 respectively(P>0. 05). All fractures in the 2 test groups but 1 in the control group were in a favorable way. Conclusion:Incisally fractured incisors restored with nanofilled composite resins can achieve the fracture resistance similar to that of intact natural tooth. Failure modes of the restored teeth are in favorable way. Additional cut of 2 mm of the incisal edge dose not affect the fracture resistance of the restored teeth.

Objective To compare the effect of different cryoprotectants and different concentrations on controlled?rate freezing of human ovarian tissues. Methods Ovarian tissues were sampled from 15 patients undergoing benign ovarian tumor surgery. Cortical slices were frozen by controlled?rate freezing using three cryoprotectants,propanediol,ethanediol,and dimethylsulphoxide,and the concentration of each cryoprotectant was 1.5 mol/L or 2.0 mol/L. Cortical slices obtained from each patient were processed with each cryopreservation procedure simultaneously. Morphology of fol?licles was studied by light and electron microscopy and the normal rate was compared with that of the fresh tissues from the patient. Results There were no significant differences in distribution of follicles of different developmental stages between each group(P<0.05). Light microscopy showed 1.5 mol/L EG and 2.0 mol/L EG groups had the best freezing effect,and the difference in the morphologically normal rate of follicles was not statisti?cally significant compared to fresh controls(P>0.05). However,the difference was statistically significant for 1.5 mol/L PROH,2.0 mol/L PROH, 1.5 mol/L DMSO and 2.0 mol/L DMSO groups(P<0.05). Electron microscopy showed the oocyte quality declined after controlled?rate freezing pro?cedure. However,the statistical analysis was not conducted due to little data. The viability of granulosa cells was significantly declined after all the freezing procedures compared to that of the fresh control tissues(P<0.01). The number of morphologically normal granulosa cells was slightly higher in the tissues which had been cryopreserved with 2.0 mol/L PROH and 1.5 mol/L EG,but no significant differences were found between any of two frozen groups(P>0.05). Conclusion Controlled?rate freezing using 1.5 mol/L EG as the cryoprotectant can better save oocytes and granulosa cells. It is a preferable freezing procedure for ovarian tissues.

Triple-negative breast cancers (TNBC) comprise a heterogeneous group of tumors characterized by poor survival and lack of targeted therapeutics. In recent years, androgen receptor (AR) has been demonstrated to play an important role in the genesis and development of TNBC. There has been increased interest in the role of AR in TNBC and AR-targeting has been introduced as a novel therapeutic option for TNBC. This review offers an overview of the relationship between AR expression and TNBC, and provides insights into the novel drugs in the development for targeting this signaling pathway.

OBJECTIVE To compare mycophenolate mofetil(MMF) with azathioprine(AZA) addition to ciclosporin-prednisone protocol after kidney transplantation in aspect of infections,and to study the etiology of pulmonary infection and urinary tract infection in the two groups.METHODS Totally 249 patients with kidney transplantation were analyzed retrospectively.These patients were divided into two groups according to the immunosuppressive regimen: AZA group(89 patients),and MMF group(160 patients).The various infectious complications were analyzed during a 1-year follow-up,and the etiology of pulmonary infection and urinary tract infection was studied in the two groups.RESULTS The total incidence of the infections,the incidences of the pulmonary infection,urinary tract infecion,wound infection,and so on,during a 1-year follow-up,were equivalent between the two groups.But the incidence of ARDS and the mortality of patients with lung infection was significantly different.The etiology of pulmonary infection was different between the two groups.Cytomegalovirous and fungal infections were higher in MMF group than those in AZA group.Also the etiology of urinary tract infection was different,the incidences of Gram-positive bacterial and fungal infections were higher in MMF group than those in AZA group.CONCLUSIONS Comparing with AZA,MMF increased the opportunity of serious lung infection.The incidences of opportunistic infection and fungal and viral infections increased obviously in MMF group.So therapy should be individualized and aimed.

Objective To investigate the effect of rAAV2 VEGF 165 (recombinant adeno associated Virus 2 vector encoding VEGF 165 cDNA) in stimulating angiogenesis, its dose effect relationship in swine acute coronary occlusion model, and to search for a suitable dose for further investigation in swine myocardium ischemia model Methods Ligation of LAD (left anterior descending coronary artery) was performed in swine modles via mini thoracotomy rAAV2 VEGF 165 (experimental group) or phosphate buffer saline (control group) was injected around the infarcted region The experimental group was divided into four subgroups: according to the amount of virus genome, which were: 1?10 11 v g (virus genome), 5?10 11 v g, 1?10 12 v g and 5?10 12 v g Animals underwent angiographic evaluation of collateral development four weeks after the operation Expression of VEGF was assessed by semiquantitative RT PCR and immunohistochemical staining Results Four weeks after the operation, expression of VEGF was detected in all the four experimental subgroups and the level of expression was higher than that of the control group Capillary density was higher in both of the 1?10 12 v g and 5?10 12 v g subgroups, compared with the control Coronary angiography demonstrated higher collateral index to the occluded LAD in the groups of 5?10 11 v g,1?10 12 v g and 5?10 12 v g than that of the control Conclusion Direct injection of rAAV2 VEGF 165 can achieve effective expression of VEGF in swine acute ischemic myocardium At certain dosage, rAAV2 VEGF 165 can promote generation of blood ressels in swine acute ischemic myocardium and 1? 10 12 v g is a more suitable dosage for swine myocardium ischemia model

Objective To investigate the effect of nifedipine on brain edema and neurological function in patients with cerebral hemorrhage . Methods 72 patients with ICH from October 2013 to October 2015 in our hospital were selected, and randomly divided into experimental group and control group, 36 cases in each group.The control group used dehydration to reduce intracranial hypertension, improve cerebral circulation, promote nutritional metabolism and anti infection and other conventional treatment,and the experimental group daily intravenous infusion of 1.0 mg of nifedipine on the basis of control group, a course of ten days.The activity dependence, clinical efficacy, MESS score, ICH score, BI score, brain hematoma and brain edema volume were observed and compared between the two groups before and after treatment.Results After treatment, the activity dependence of the experimental group was significantly better than that of the control group ( P <0.05 );the clinical effective rate of the experimental group was significantly higher than that of the control group (P<0.05).BI scores of both groups were increased after treatment, MESS scores were reduced(P<0.05);The BI score of the experimental group was significantly higher than that of the control group (P<0.05),and the MESS score was significantly lower than that of the control group (P <0.05).The volume of cerebral hematoma and the volume of cerebral edema were significantly reduced after treatment in both groups (P<0.05),there was no significant difference in the volume of cerebral hematoma between two groups,there was significant difference in the volume of cerebral edema between two groups (P <0.05).Conclusion Nifedipine can effectively reduce cerebral edema in patients with cerebral hemorrhage, reduce the degree of neurological deficit, improve clinical efficacy.