The Socialist legal construction needs to strengthen the legal education.It is significant to seek for the path of legal education in order to enhance the actual effect of legal education.The path of legal cducation includes traditional education,utilitarian education,reasonable education,legitimate education and feeling education,etc.We can get a better actual effect of legal education if different paths of legal education (traditional education,utilitarian education,reasonable education,legitimate education and feeling education) can be integrated,infiltrated and complemented.

The tumorigenesis of breast cancer is a multistep process with many factors.The microRNAs (miRNA) participates in the development and distance metastasis of tumor by regulating proliferation,apoptosis and migration of tumor cells.The study of the mechanisms that miRNA impacting breast cancer cell proliferation and metastasis may provide new ideas for the diagnosis and treatment of breast cancer.

Objective To explore the influences of indoor and outdoor sources of air pollutants on NO 2 concentra tions in indoor air.Methods The dynamic variations of NO 2 concentrations in indoor and outdoor air were continuously monitered by ML 9841B chemiluminescence continuous monitoring analyzer in2families of White haven town of west Cumbrra,UK.Results During the period of indoor air monitoring,typical background concentrations of NO 2 in air in the center of White haven were between19and28?g /m 3 (10min-mean),and rose to38-47?g /m 3 (10min-mean)during the morning and evening rush of traffic.NO 2 concentration increased about 190?g /m 3 (10min-mean)after the use of a gas cooker in the kitchen A1-hour mean concentration of253?g /m 3 was recorded in the kitchen air of one of the houses,which substantially exceeded the NAQS standard of200?g /m 3 .Conclusion The increase of NO 2 concentration in kitchen air induced by the use of gas appliances played a more important role in influencing the indoor air quality than outdoor air did.

Objective To investigate the gene polymorphism of HLA-DR locus and feature of HLA haplotypes of Han Population in Tianjin area.Methods Reverse PCR-SSOP typing results of HLA-DR alleles of 3000 cord blood units from Han population pregnant women in Tianjin area were compared to those of European Caucasian and the Han populations in Xi’an area.Results DRB1 *15, allele presented the highest frequency,followed by DRB1 *09,DRB1 *07,DRB1 *12,and DRB1 *04.The main haplotypes were A *02-DRB1 *09,A *02-DRB1 *15,B *13-DRB1 *07,A *02-DRB1 *12,A *30-DRB1 *07 and B *46-DRB1 *09 in sequence.The frequencies of DRB1 *12 and DRB1 *09 alleles were significantly higher than in European Caucasian,while the frequencies of DRB1*01 and DRB1 *03 alleles were significantly lower than those in European Caucasian.As compared with that of the Han population in Xi’an,there was not significantly difference except a decrease in frequencies of DRB1 *04 and DRB1 *13 alleles.Conclusions Distribution of the allelic polymorphism of HLA-DR locus was similar to those in northern Han population,such as in Xi’an area,and it was obviously different from those in European Caucasian.

Oxidative damage theory is currently one of the predominant theories on the mechanisms of aging. Previous research has shown that antioxidants can extend the lifespan in the model organism by scavenging free radicals,inducing the expression of stress related genes and hormesis. However, recent studies have suggested that these pharmaceuticals may cause serious side effects,such as promoting oxidation,increasing the risk of cancer,and destroying the metabolic balance. The low absorption and targeting property also limit the efficiency of most antioxidants. As a result ,the correlation between antioxidants and lifespan extension remains to be demonstrated. We reviewed the research progress in the field of lifespan extension by antioxidants in recent years and provided references for future research in related areas.

Oceanic carbon monoxide(CO) has been of biogeochemical interest due to its significant role in global carbon cycle and the greenhouse effect. A headspace method coupled with ta3000 trace gas analyzer system for the determination of CO in seawater was developed. The effects of temperature, equilibrium time and water/gas volume ratio on the sensitivity of headspace analysis were studied in detail. The results showed that CO concentrations in seawater were measured successfully by the 50-mL glass-only syringes with a water/gas volume ratio of 44∶ 6 and an equilibrium time of 5 min at 20 ℃ room temperature. Under the optimized conditions, the linear range of concentrations of CO was 0-2.7×10~(-6), r=0.999,p<0.0001. The relative standard deviation of the analysis method was <4.4%, with a detection limit of 0.02 nmol/L. The average recovery of CO was 90.5%. The concentrations of CO in surface waters of the North Yellow Sea were measured using this method and ranged from 0.20 nmol/L to 3.13 nmol/L, indicating that this method can be successfully applied to the detection of the in situ CO concentrations in seawater.

It was found that Ag nanoparticles (NPs) could enhance the chemiluminescence (CL) intensity of luminol- potassium ferricyanide system. On the basis of enhancement effect,a flow injection method was developed for the determination of terbutaline sulfate. The structure and shape of Ag NPs were characterized by transmission electron microscopy. The UV-Vis absorption spectra and chemiluminescence spectra suggested that new luminophor was not formed after Ag NPs introducing in luminol-potassium ferricyanide chemiluminescence system. A possible mechanism of Ag NPs strengthening on luminol-potassium ferricyanide CL reaction was also discussed. The effect of concentration of luminol,potassium ferricyanide,sodium hydroxide and Ag NPs on CL reaction was investigated respectively. In the optimum conditions,the linear range was 1.0×10~(-9) -2.0 ×10~(-5) g/L(r =0.9935) and the detection limit was 1×10~(-10) g/L. The relative standard deviation (RSD) was 3.6% for 1. 0 ×10~(-6) g/L terbutaline sulfate (n = 11 ). The recommended method has been successfully applied to the determination of terbutaline sulfate tablets and the recovery was between 98. 5% - 102. 5% ,moreover the results were almost identical with the same results of Pharmacopoeia method.

Objective:To synthesize substituted pyridine propynyl carbamates and to test their antimicrobial activities. Methods: Eight novel compounds were designed and synthesized. Antimicrobial tests in vitro were carried out with 8 common mildews (Aspergullus niger, Aspergillus flavus, Aspergillus versicolor, Trichoderma viride, Paecilomium varioti Bainier, Chaetomium globsum, Penicillium citrinum, Cladochytrium clodospoium) and 5 bacteria (Escherichia coli, Pseudomonas fluorescens, Bacillus fluorescens, Bacillus megatherium). Results: All compounds synthesized showed antimicrobial activity, especially the compound 1f, whose activity was more potent than that of compound 3-iodo-2-propynyl-butyl-carbamate (IPBC). Conclusion: Compound 1f is worth further studying and exploration.

Objective To explore the clinical effect of hysteroscopic scar defect correction in the treatment of cesarean scar.Methods Eighty-four cases patients with cesarean section uterine incision scars who were treated in Affiliated Hospital of Hubei Polytechnic University from August 2015 to July 2016 were selected and randomly divided into observation group with hysteroscopic surgery and control group with vaginal surgery,42 cases in each group.The operation condition,clinical efficacy and the incidence of complications of the two groups were observed and compared.Results The amomt of blood loss,hospitalization expenses,hospitalization time and operation time in the observation group were (22.45±3.78) ml,(3028.89±218.79) yuan,(3.89 ±0.80) d,(20.13±2.90) min respectively,in the control group were (40.56±5.48) ml,(4189.58±269.78)yuan,(5.46 ± 1.02) d,(30.78 ± 6.99) min respectively,the differences were significant (P ＞ 0.05).The incidence of infection,relapse and incisional wound healing in the observation group were significantly lower than in the control group,the differences were significant (P＜0.05).The total effective rate was 90.48％ in the observation group and 85.71％ in the control group after treatment,the difference was not significant(P ＞0.05).Conclusion Hysteroscopic scar repair has the same effect as that of vaginal surgery,but the rate of blood loss and complication is lower than that of vaginal operation,which is safer and more effective.