1.Studies on origin, morphology and histology of Galla Cinnamomi Camphorae specially produced in Jiangxi Province
Cuisheng FAN ; Xiaolan CHU ; Xiaomei FU ; Chunlin YUAN ; Jianrong HUANG ;
Chinese Traditional and Herbal Drugs 1994;0(08):-
Object To study the origin, morphology and histology of Galla Cinnamomi Camphorae(GCC). Methods By the literature investigation and the survey in the production area, GCC was identified by microscopic technique. Results The origin and the medicinal part of GCC were defined. Conclusion GCC is the abnormal fruit of Cinnamomum camphora (L.) Presl which has been infected by Exobasidium sawadae Yamada and formed with hymenium and fruit. The characters in morphology and histology of GCC provide the scientific reference of identification of the crude drug.
2.Effects of Lactobacillus rhamnosus on postpartum depression-like behavior, monoamine neurotransmitter and intestinal flora in mice
Teng LI ; Xiaolan ZHOU ; Jing CHU ; Liqin WANG ; Guofen CAO ; Haimiao ZHANG
Journal of Xi'an Jiaotong University(Medical Sciences) 2021;42(6):862-867
【Objective】 To explore the effect of Lactobacillus rhamnosus on postpartum depression (PPD) and its potential mechanism. 【Methods】 The mouse model of PPD was established by using dexamethasone sodium phosphate during pregnancy. At the end of adaptive feeding, 50 pregnant female mice were randomly divided into low-dose group (group Ⅰ), high-dose group (Group Ⅱ), positive control group (Group Ⅲ), model control group (Group IV), and blank control group (Group Ⅴ). The mice in Group Ⅰ and Group II were given Lactobacillus rhamnosus 1×107 and1×108CFU(kg·d). The mice in Group Ⅲ were given 1.8 mg /(kg·d) paroxetine, and the mice in Groups IV and V were given the same amount of normal saline for 4 weeks. The 24-hour food consumption test, open field test and sugar water consumption test were used to detect the behavior of mice in each group. The concentrations of 5-hydroxytryptamine (5-HT), norepinephrine (NE), and dopamine (DA) were determined by RP-HPLC. The changes in Enterococcus faecalis, Bifidobacterium, Lactobacillus and Escherichia coli in the cecum of mice were detected by Real-time fluorescence quantitative PCR (RT-qPCR). 【Results】 Before modeling, there were no significant differences in food intake, weight change rate, open field moving distance and speed, and percentage of sugar consumption among the groups (P>0.05). After modeling, there was no significant difference in food intake or weight change rate among the five groups, but the open field moving distance, moving speed and percentage of sugar preference were significantly reduced (P<0.05). After intervention with Lactobacillus rhamnosus, compared with Group Ⅳ, the depression-like behavior in Group Ⅰ and Group Ⅱ mice was improved; the weight change rate, open field moving distance and speed, percentage of sugar preference, and monoamine neurotransmitter concentration in Group I and Group Ⅱ were significantly increased compared with those in Group Ⅳ (P<0.05), while Enterococcus faecalis, Escherichia coli and lactobacillus were significantly decreased (P<0.05), and Bifidobacterium had an upward trend, but without significant difference. There was no significant change in food intake. 【Conclusion】 Lactobacillus rhamnosus can improve the depression-like behavior, affect monoamine neurotransmitters in mice, and regulate intestinal flora, which provides a new direction for studies on postpartum depression.
3.Working Mode and Case Analysis of the First Pharmaceutical Ward Rounds in Our Hospital
Wei ZHUANG ; Suying YAN ; Xiaolan LIN ; Fei CHEN ; Li GAO ; Yingnan FENG ; Jing TANG ; Beibei JIA ; Yanqi CHU
China Pharmacy 2021;32(17):2129-2133
OBJECTIVE:To est ablish the working mode of the first pharmaceutical ward rounds of clinical pharmacists in our hospital,in order to provide a useful reference for establishing a national standardized pharmaceutical ward rounds model. METHODS:By sharing the clinical cases of the first pharmaceutical ward rounds ,the work content and process of the first pharmaceutical ward rounds in our hospital were introduced. RESULTS & CONCLUSIONS :The clinical pharmacist ’s first pharmaceutical ward round in our hospital mainly includes self introduction of clinical pharmacists ,diagnosis of patients ’condition under the guidance of doctors ,collection and evaluation of patients ’previous medication information (including previous medication varieties ,usage methods ,efficacy and safety evaluation ),assistance for doctors in formulating initial treatment plan , carrying out initial medication and diet education ,and intensive communication and cooperation with nurses. The development of first pharmaceutical ward rounds promotes the rational use of drugs in clinic ,elevates the hospitalization satisfaction of patients and improves the professional quality of clinical pharmacists.