Objective]To explore the experiences in syndrome differentiation and treatment of acute leukemia from chief physician Xia Xiaojun. [Metheod] Learning my teacher diagnosing the disease, I refer to literature and combine with the study to summarize and introduce my teacher's clinical experiences and academic point of view in treatment of acute leukemia from the etiology and pathogenesis, syndrome differentiation, treatment, prescriptions and so on. [Results]Teacher Xia thinks that the emphasis of acute leukemia is deficiency in origin and excess in superficiality.The treatment is replenishing qi and blood,enforcing spleen and nourishing kidney and detoxication and activating blood stasis.Weighing the illness samples priorities and distinguishing between primary and secondary so as to improve the curative effect.[Conclusion]Teacher Xia bases on the progress of acute leukemia in different stages of syndrome characteristics,combines traditional Chinese with western medicine and finds the Huisheng Decoction series hebal medicine for treatment according to syndrome differentiation.The clinical curative effect is remarkable and the knowledge is worthy of our further in-deep learning.