Objective To investigate the clinical characteristics of methylmalonic acidemia.Methods Methylmalonic acidemia diagnosis and treatment of 12 cases of clinical data were collected,the clinical manifestations,laboratory examinations,gas chromatography/tandem mass spectrometry analysis of the measurement results of urine organic acids,blood gas analysis,glucose,lactic acid,ammonia and other characteristics were sumarized,and the clinical features and outcome of the situation were also sumarized.Results 1 year old first visit eight cases,12 cases,8 cases from rural areas;12 cases of major treatment complained of anorexia,poor spirit hospitalized one case;respiratory infection hospitalized five cases; seizure hospitalized three cases;weight gain admission,one case;vomiting admitted three cases,three cases of drowsiness,coma admitted one case,the movement behind the main complaint admitted two cases.After hospitalization check urine organic acid analysis found significantly increased methylmalonic acid,respectively,while ammonia,lactic acid increased,high blood sugar,high uric acid,low albumin,urine protein abnormalities,abnormal urine ketone bodies,abnormal increased anion gap,video science and abnormal electrophysiological examination.Diagnosed with methylmalonic acidemia,according to the case were given VitB12,betaine,folic acid,L-carnitine,limiting protein intake and other treatment.Symptomatic treatment improved in seven patients,two patients were lost;automatically discharged one case,two cases of death.Conclusion Methylmalonic acidemia based on clinical characteristics,so early detection,early diagnosis,early treatment will help to improve prognosis.

Hepatoblastoma (HB)is the most common malignant liver tumor in children.Surgical resection was the major treatment approach to HB,whereas more than 60% patients had unresectable mass at diagnosis,even though complete resection,there were about 30% patients recurrent.With the introduction of adjuvant chemotherapy,the treat-ment of HB has been developed to multidisciplinary cooperation from single surgical resection,such strategy greatly im-proved the prognosis of children with HB,but there still be a great challenge in the treatment of high -risk patients.All famous children′s HB study groups have begun to focus on the optimization of chemotherapy,surgery opportunity,strate-gy based on risk -stratification,looking for new potential therapeutic targets and prognosis -related risk factors.

The medical student took future the medical worker.shoulders iS protecting the humanhealth the sacred mission,must havethe higher humanities quality,stronger society adaptiveness.Facingthe current medical student humanities qual ity present situation,thehigher medicine collegesand universities must transform the educationidea,reasonably establishes the humanities curriculumsystem,strengthens the teachers troop to COnstruct.the creation gOOd eall;puSctllture atmosphere and soon.strengthens the medical studenthumanities quality raise,sharpens the medical studentsocietyadaptiveness.

Objective To know the dynamic dose of individual external exposure for radiological workers in Qinghai province from 2001 to 2005. Methods Individual exposed dose for 2 733 radiological workers were measured with thermoluminescent method. Results Individual average effective dose was less than 0.53 mSv/a, 97.84% of radiological workers dose was less than 5 mSv/a. Conclusion The individual external exposure level for radiological workers is less than 5 mSv/a in Qinghai Province and it does not exceed the national standard limit.

Since the 1990s,models of genetically modified mice(gene knockout,mutation or transgene overexpression) have been increasingly used in heart research.The findings from this class of murine models have contributed significantly to a number of research breakthroughs achieved in the last 15 years.Currently,the number of genetically modified mouse strains has been increasing steadily.These models that targeted a family or a functionally relevant group of proteins have formed systemic tools for research use.The database of mouse cardiac phenotype has been established.Meanwhile,the research methodology and strategic approach exploring mouse cardiac phentypes at molecular to in vivo levels have been mature.It is expected that the use of this class of genetically targeted mouse models will become increasingly important in future research.

Eye and nervous system are anatomically and physiologically very close.About 40% of the nerve fibers in brain are correlated with visual function.Seven of twelve cranial nerves are straightly correlated with visual afferent or eye movement.Neurological diseases can affect eye in many different ways.Furthermore,systemic disorders can cause secondary neurological lesions or even primary neurological disorders,which sequentially show ocular symptoms and signs.Better understanding of the close relationship between eye and brain,together with intimate cooperation between ophthalmologists,neurologists,neurosurgeons and other specialties,are the key point to improve our neuro-ophthalmology service in China.

Objective To investigate the feasibility and safety of combined coronary and renal angiographies through transradial approch.Methods Three hundred and twenty patients in hospital from August 2007 to April 2009 who underwent combined coronary and renal angiographies through transradial approach were included in this study.Renal artery angiography of 300 cases was done by 5 FMP-A1 catheter (MP-A1 group),and 20 cases was done by TIG catheter (TIG group).Control group had 625 patients in hospital from January 2004 to April 2009 who underwent combined coronary and renal angiographies through transfemoral approach.The achievement ratio,operating time,dosage of contrast agent and complication of angiography were observed.Results The achievement ratio was higher in MP-A1 group [97.0%(291/300) ]and control group [98.4%(615/625)]than that in TIG group [40.0%(8/20)](P< 0.01).The operating time was (32.21 ± 3.37) min and the dosage of contrast agent was (52.72 ± 7.91) ml in MP-A1 group,and it was (30.78 ± 3.23) min and (51.88 ± 7.22) ml in control group respectively.There was no significant difference between two groups(P>0.05).The operating time was (26.42 ±4.31) min and the dosage of contrast agent was(51.72 ± 10.11) ml in TIG group.There was significant difference in the operating time between TIG group and the others groups (P < 0.05).The complications of angiography through transradial approach (0.9%,3/320) were less than those through transfemoral approach (3.0%,19/625) (P <0.05).Conclusions Renal artery angiography through transradial approach by 5 F MP-A1 catheter(125 centimeter) is safe and has minor complication.The achievement ratio of transradial approach for renal artery angiography by 5F MP-A1 catheter is higher than that by TIG catheter.

Objective To discuss the etiology,clinical features,diagnosis and treatment measures of female pseudohermaphroditism.Methods Five Cases,of female pseudohermaphroditism were collected.The etiology,clinical features,diagnosis and treatment measures were discussed.Results One case induced by exogenous androgenic hormones,4 cases induced by congenital adrenal hyperplasia.All the 5 cases presented with abnormal development of vulva and the sex chromosomes karyotype of 46XX.The combined treatment ofreconstructive surgery (5 cases)and supplementary glucocorticoid (4 cases)wefe performed.After 3months,the levels of adrenocorticotrophic hormone and virosterone were normal.Followed up for 1-10 years,The postoperative appearance of external genitalia was similar to the normal.The secondary sex characters were improved obviously,3 cases were mainly feminilism,2 cases existed different degree of psychologic obstacle.Conclusions The diagnosis and treatment in the early stage are very important.The combination treatment of surgery and medicine for the patients with female pseudohermaphroditism is satisfied.

Arsenicals ; therapeutic use ; Humans ; Leukemia, Promyelocytic, Acute ; drug therapy ; Medicine, Chinese Traditional ; Oxides ; therapeutic use

OBJECTIVETo observe the effect of conical atone needle on foot combined with Nan anvil at Yintang (CV 29) for insomnia.

METHODSSeventy patients were randomly divided into a ibian technique group and an acupuncture group,35 cases in each one. In the Sian technique group, conical stone needle on foot combined with bias anvil at Yintang(GV 29) were used,and the therapy was applied at Yongquan(KI 1), Taichong(LR 3) and Gongsun(SP 4), etc. In the acupuncture group, common acupuncture was implemented at Sanyinjiao(SP 6), Shenmen (HT 7) and Sishencong(EX-HN 1), etc. In the two groups, treatment was given for 2 weeks,once a day. There were two days to have a rest between 5-time treatment. The change of Pittsburgh sleep quality index(PSQI) before and after treatment was recorded and the clinical effect was observed after 10-time treatment and in two weeks aftet treatment.

RESULTSAfter treatment,the total scores of PSQI were declined significantly compared with those before treatment in the two groups(both P<0. 01). The total PSQI scores after treatment,the curative and effective rates and total effective rates when followed up bad no statistical significance(all P>0. 05).

CONCLUSIONConical stone needle on foot combined with Sian anvil at Yintang(GV 29) treating insomnia is safe and effective,and this treatment acquires similar efficacy with less suffering.

Acupuncture Points ; Acupuncture Therapy ; instrumentation ; Adult ; Female ; Humans ; Male ; Middle Aged ; Needles ; Sleep ; Sleep Initiation and Maintenance Disorders ; physiopathology ; therapy ; Treatment Outcome