Asthma is a chronic airway inflammatory disease.Detection and evaluation of airway inflammation has important clinical significance in asthma diagnosis and severity judgement.It is also important to select drugs,dosage,and withdrawal time for patients whose symptoms have been controlled.So,it is necessary to find the technology which can response to airway inflammation to guide the asthma diagnosis and therapy.At present,many inflammatory biomarkers have been researched including exhaled nitric oxide,leukotrienes,exhaled breath condensate determination,Periosrin,YKL-40 etc.This review summarizes the biological characteristics and clinical application of inflammatory markers in asthma.

The Wireless Body Area Network (WBAN) is a key part of the wearable monitoring technologies, which has many communication technologies to choose from, like Bluetooth, ZigBee, Ultra Wideband, and Wireless Human Body Communication (WHBC). As for the WHBC developed in recent years, it is worthy to be further studied. The WHBC has a strong momentum of growth and a natural advantage in the formation of WBAN. In this paper, we first briefly describe the technical background of WHBC, then introduce theoretical model of human-channel communication and digital transmission machine based on human channel. And finally we analyze various of the interference of the WHBC and show the AFH (Adaptive Frequency Hopping) technology which can effectively deal with the interference.
Computer Communication Networks ; Humans ; Models, Theoretical ; Wireless Technology

Objective To evaluate the efficacy and safety of acarbose tablets combined with protamine zinc recombinant lai pulp mixing insulin injection in the treatment of elderly patients with type 2 diabetes.Methods 170 elderly patients with type 2 diabetes were randomly divided into the observation group and the control group.85 cases in the observation group were given acarbose tablets combined with protamine zinc recombinant lai pulp mixing insulin injection,85 cases in the control group received aspart 30.The patients were followed up for 12 weeks,the blood glu cose levels,blood glucose fluctuation,glycosylated hemoglobin (HbAlc),the incidence of hypoglycemia and insulin dosage were observed.Results' The level of fasting plasma glucose (FPG) (t =9.92,P ＜ 0.05),2h postprandial blood glucose(2hPG) (t =18.18,P ＜0.05),the mean blood glucose within 4h(t =13.62,P ＜0.05),days of average blood glucose fluctuations (t =14.56,P ＜ 0.05) of observation group dropped significantly compared with that before treatment;HbAlc achieved rate(6.5％)of the observation group and control group were 35.29％,28.23％,re spectively,HbAlc achieved rate (7.0％) of observation group and control group were 57.64％,52.94％,the differences were not statistically significant(all P ＞ 0.05).The dose of insulin was significantly lower in the observation group(20.11 ±3.36) u/d than(35.78 ±4.68) u/d in the control group(t =25.08,P ＜0.01).There were 2 cases of hypoglycemic events and 3 cases in the control group.Conclusion Protamine zinc recombinant insulin lispro injection combined with acarbose has reliable clinical efficacy and safety.

This paper reviews the long-term care policy in Japan and discusses successes and challenges in order to provide policy guidelines for China. All Japanese adults aged 65 or over are covered by the long-term care in-surance ( LTCI) program and are eligible for both in-home and institutional-care services following a thorough, sys-tematic care certification process. The program is financed by a mix of general tax revenues from the three levels of gov-ernment , income-tested premiums, and standardized co-payments. A key success of the policy is its universal and compre-hensive coverage. Notwithstanding this success, increasing costs remain a challenge as Japan’s population ages and the number of LTCI users increases. Learning from the experience of Japan, China should establish a long-term care system, which covers all the aged population, mainly focuses on in-home care, and qualifies social funding to invest.

Epilepsy is a common disorder of neurological system in children.Inborn errors of metabolism (IEMs) is one of an important etiology of epilepsy.Seizures may be the first and the major presenting feature of IEMs.IEMs are a relatively rare cause of epilepsy,but their recognition and diagnosis is very important because several disorders are treatable.This review will concentrate on diseases where epilepsy is the predominant clinical manifestation and especially where the disease course can be positively influenced by specific metabolic therapies.

Aim To clone the muscarinic receptors M1, M3 and M5 sequences of astrocyte cells,and compare the gene and protein sequences with those of neurons. Methods Specific primers were designed to clone the M1, M3 and M5 sequences of astrocyte cells by RT-PCR according to those of neurons,then sequenced the sequences. Result By comparing the M1, M3 and M5 sequences expression by astrocyte cells with those by neurons and we found four, eight,and one different bases and one, four and one different amino acids in M1, M3 and M5 between astrocyte cells and neurons respectively. Conclusions The gene and protein sequence differences are evident in M1, M3 and M5 between astrocyte cells and neurons.

Using HB55 McAb, we detected HLA-DR antigens on Daudi, H18, PBL and K562 cells by dot-ELISA. Results corresponding to situation of the antigen expressions on various cell lines were obtained: colour reaction in Daudi, H18 cells and PBL was positive in different degree and K562 sample presented negative reaction. Chromatogram peaks were printed by Dual-Wavelength Flying-Spot scanner CS-9000 (SHIMADZU). Areas and high values of peaks, meaning size and colour of spot respectively, were increased with cell concentration. Both cell concentration and volume of cell suspension did not influence the diffusion of sample. An analysis for the antigen expression on cell surface and its dynamic change can be supplied by the technique.The study on quantitative assay of MHC class Ⅱ antigens on cell surface are still going on.

Objective To sum up the characteristics of hemorrhagic fever with renal syndrome(HFRS)and acute pancreatitis,to improve the understanding of the cases of atypical HFRS,reduce the misdiagnosis rate and improve the cure rate.Methods 3 cases of HFRS complicated with acute pancreatitis in our hospital from 2011 to 2015 were retrospectively analyzed.Results 3 cases were middle -aged men,with an average age of 46.6,of which two cases occurred in Huangling county in the city,the remaining 1 case occurred in Yichuan county of the city. Occupation was the railway workers,drivers,farmers.Respectively occurred in February,July,December.3 cases of blood routine,urine routine,blood coagulation performance were consistent performance for RBC,WBC,PLT decrease;hematuria,proteinuria;3 cases of plasma amylase were higher than that of more than 3 times the normal value,the serum lipase was higher than the more than 3 times the normal value;hemorrhagic fever antibodies were positive;treatment of 2 cases with hemodialysis treatment,1 case underwent intestinal dialysis treatment,successful treatment of all.Conclusion HFRS with acute pancreatitis patients were less,easy to be misdiagnosed or ignored,easy illness of incur loss through delay and once with acute pancreatitis will add to the original condition,treatment more difficult tend to have higher mortality rate.It should be according to the clinical manifestations,early blood and urine amylase, abdominal B ultrasound and CT examinations of the abdomen as soon as possible,to improve the accuracy of diagnosis, take appropriate treatment measures,especially blood dialysis treatment,can reduce the mortality rate.

Intracranial aneurysms are mainly caused by the local arterial wal defects and the increased intraluminal pressure. Usualy, the unruptured smal aneurysms are asymptomatic, and the ruptured aneurysms can cause subarachnoid hemorrhage. So far, the etiology and pathogenesis of intracranial aneurysms are not fuly understood. A lot of evidence has showed that intracranial aneurysms are a complex disease of environmental factors and multi-gene interaction. This article reviews the correlation between polymorphisms of elastin and colagen type Ⅰ α2 genes and intracranial aneurysm.

OBJECTIVE:To explore the necessity of pharmaceutical care provided by clinical pharmacists during the use of ad-vertised drugs. METHODS:Through retrospectively analyzing drug advertisements permission number of which had been revoked issued by China Food and Drug Administration during Jan. 2013-Jun. 2015 statistically,the reasons for permission withdrawal were analyzed to put forward the focal point of pharmaceutical care development. RESULTS & CONCLUSIONS:A total of 46 items of permission number had been revoked,including 45 items of Chinese patent medicine (97.83%),1 item of western medicine (2.17%). The reasons for permission revoking mainly included overstating therapeutic efficacy without authorization,guaranteeing onset time,guaranteeing recovery in certain time,propagandizing drugs in the name of experts,etc. These drug advertisements sent relatively one-sided information so as to easily mislead patients and consumers to use drug irrationally. So,it is necessary to provide pharmaceutical care by clinical pharmacists about this kind of drug. The focal points of pharmaceutical care contain telling patients usage and dosage detailedly,and explaining possible ADR and relevant countermeasures;emphasizing different therapeutic efficacy,onset time and recovery time due to individual difference;strengthening prescription check and medication suitability ap-praisal,and so on.