98%.Thick myofibers were observed by transmission electron microscopy after induction with 5-aza.Four weeks after transplantation,the left ventricle ejection fraction,the movement extent of left ventricle,left ventricle systolic wall thickening and dp/dt of rabbits were all higher than those of the control group and cardiac infarction model group(P

ObjectiveTo explore the sleep quality and psychical health of the patients with cancer.Methods96 cancer patients were tested by Pittsburgh Sleeping Quality Index(PSQI) and Symptom Check List 90 (SCL-90). ResultsThe PSQI scores of the patients with ache were higher than that without ache (P<0.05).Sleep problems were occurred in 87.55% of the patients. Sleep quality of 9.38% of patients were poor. The sleep quality of the male patients were better than those of the female (P<0.05). Apart from interpersonal sensitivity, paranoid ideation and psychoticism, scores of the rest were higher than the general people(P<0.05).10.2% of the patients with cancer had psychical problems. Apart from sleep time and using sleep pill, there was a high correlation between the scores of SCL-90 and PSQI (P<0.05). ConclusionThe results showed that sleep problems of the patients with cancer affected their psychical health.

Carrying out targeting an oncolytic adenovirus strategy in gene therapy of pancreatic cancer is a new direction.Currently,related research including vitro test and animal models vivo test,targeted strategies on molecular biology and gene level are carried out.Some of oncolytic adenovirus drugs have entered phase Ⅲ clinical trials.Oncolytic adenoviruses alone or in combination with other treatments,can enhanced anti-tumor effect.

Objective To compare heparin binding protein (HBP)and procalcitonin(PCT)in the evalua-tion of in prognosis of patients with sepsis in ICU.Methods 80 sepsis patients were selected.According to the sever-ity of the disease,they were divided into general sepsis group (n =31),severe sepsis group (n =29)and death group (n =20).The differences of HBP and PCT in three groups were compared.Results Compared with HBP and PCT in the general sepsis group[(3.91 ±0.36)ng/mL,(1.26 ±0.35)ng/mL)],PCT of the severe sepsis group (11.81 ± 0.54)ng/mL was significantly increased(F =2 777.87,P =0.000);HBP and PCT of the death group[(15.28 ± 1.21 )ng/mL,(36.68 ±0.36)ng/mL)]were significantly increased compared with the general sepsis and severe sep-sis groups (F =49 789.02,P =0.000).Conclusion The sensitivity of PCT was significantly higher than HBP in the groups,PCT was better in judging the prognosis of sepsis.

Dietary management plays an important role in the diabetes mellitus therapies. Effective dietary management can find the deficit of dietary management in patients with diabetes mellitus. Recently these tools primarily were consisted in the comprehensive diabetes mellitus management instruments and a fraction of the ones aim at the evaluation of the dietary management for diabetes. Timely and effective assessment of the effect on diabetes diet management depends on these tools. Therefore, the feasibilities, usefulness and deficit about these instruments were analyzed to prompt the application and investigation of the instruments in the future.

Objective To explore the effect of water analgesia on the pain relief for primiparas in labor, especially on the point of the acutest pain and total time of severe pains by tracking and comparing with remifentanil patient- controlled intravenous analgesia and the conventional vaginal delivery. Methods A total of 139 singleton and full-term primiparas who chosed analgesia labor were selected. There were 3 groups:56 cases in water analgesia group (hereinafter referred to shortly as water group), 37 cases in remifentanil patient-controlled intravenous analgesia group (hereinafter referred to shortly as vein group ) and 46 cases in traditional vaginal delivery group (hereinafter referred to shortly as traditional group). In addition, labor pain intensity was assessed with numerical rating scale (NRS). All groups were evaluated by NRS score in five different time points during the delivery:cervical dilation to 2-3 cm or 1 minute before labor analgesia; labor analgesia after 10 minutes; labor analgesia after 30 minutes; labor analgesia after 60 minutes;point of acutest pain. Meanwhile, total time of acutest pain, progress of labor, use of oxytocin, mode of delivery, postpartum hemorrhage and neonatal asphyxia were all observed. Results Comparison of labor progress and postpartum bleeding, mode of delivery and neonatal Apgar score in three groups of primipara showed no significant difference (P>0.05). Compared with the traditional group, the NRS score and point of acutest pain in water group obviously declined, the total time of severe pain shortened 36.58 min on average, which showed significant difference (t=-4.400, P<0.05). Compared with the vein group, the NRS score of water group at 10 minutes after labor analgesia was below the vein group (t=-2.358, P<0.05), so was point of acutest pain (t=-2.703, P<0.05). But the score of water group was higher than intravenous analgesia after 60 minutes, which showed significant difference (t=2.833, P<0.01). The rate of oxytocin application in water group was only 12.5%(7/56), significantly less than the rate in vein group, which was 37.84%(14/37), there were significant differences (χ2=8.182, P<0.05). Conclusions Water analgesia can effectively alleviate maternal pain and reduce intrapartum intervention, and more, less influence on maternal and newborn, and is a safe and effective analgesia method.

CD4 + CD25 + regulatory T cells are produced in the thymus and have anergic and immunosuppressive properties.Researchers measured the antibody level related with CD4+ CD25+ T cells,CD4+ CD25hi T cells,CD4+ CD25+ Foxp3 and CD4+ CD127 in regenerative anemia,leukemia,ITP,NHL,MDS.Then they got the conclusions that regulatory T cells decreased in the autoimmune blood diseases and increased in the neoplastic diseases.The regulatory T cells have great prospect in the treatment of autoimmune diseases,allergic diseases,transplant rejection,tumors and specific vaccination.

After a brief description of standards for HL7 and its application in foreign countries and China, the lo-calization and implementation principles of HL7-based application of integrated medical information system, and its advantages and disadvantages were analyzed with its development trend in China pointed out.

Myeloid-derived suppressor cells (MDSCs) play an important immunosuppressive role during the tumor development process.And the progression of many tumors are always accompanied with abnormal accumulation of MDSCs.Moreover,both the accumulation and functions of MDSCs could be affected by complicated factors.Therefore,how to effectively reduce the immunosuppressive effects of MDSCs in oncotherapy has become the focus of scholars.Recent studies show that anti-tumor drugs can affect many biological behaviors of MDSCs.