Objective To observe the clinical efficacy of peppermint oil capsules combined with domperi-done in the treatment of bile reflux gastritis(BRG)after gastric surgery.Methods Totally 47 patients with BRG after gastric surgery were treated with peppermint oil capsule (0.9g,tid)and domperidone(10mg,tid).Each patient's gas-troscopic manifestations and histopathology were rechecked after 4 weeks.The efficacy was observed on the improve-ment of symptoms and gastric mucosal injury,and on the reduction of bile reflux.Results 42 patients attained satis-factory therapeutic effect with the total efficiency rate of 89.4%.No adverse effects during the treatment period. Conclusion Peppermint oil capsules combined with domperidone shows better efficacy in treatment of BRG after gastric surgery.

Not only shofld the process of program establishment be emphasized for the management of the newly developed programs,but also great attention should be paid to the normal management after the establishment.The management and supervision should be practiced on the whole process of the programs newly developed by hospital departments so that the written report on the program advancement should be submitted in the half a year as planned.Furthermdre,an exclusive account should be opened for the granted fund of the program;and the establishment of new research program and the purchase of equipment should be approved according to the related rules and regulations of the hospital.

Purpose To analyze the 64-row spiral CT manifestations and evaluate the diagnostic value in early primary ureteral carcinoma.Materials and Methods Fifteen cases of early primary ureteral carcinoma proved by surgery and pathology were reviewd.Unenhanced scan,enhanced scan in arterial phase,parenchymal phase,delayed phase and CPR construction were performed in all patients.MIP were performed in 10 cases.Results ① the localization of lesions:7cases were located at the right ureter and 8 cases at the left.2 cases were located at the upper portion of the ureter,6 at mid portion,and 7 at lower portion;② CT manifestations:8 cases showed irregular thickened wall and central lumen stenosis,4 cases eccentric soft tissue mass in lumen and crescent or linear vestigial lumen,3 cases soft tissue density and obsolescent lumen;③the enhanced features:the tumor was demonstrated apparent and uniform enhancement in 13 cases,inhomogeneous enhancement in 2 cases after administration of contrast medium;④ the accompanied signs:proximate renal and ureteral presented distention,dropsy in different degrees,5 cases appeared delayed development.Conclusion 64-row spiral CT volume scan and 3D reconstruction with multiplane and multiorientation,combined with axial enhanced scan,can show lesions dimensionly and increase the dignostic accuracy in early primary ureteral carcinoma,which has an important value.

Objective To screen single nucleotide polymorphism(SNP)of DNA methyltransferase 1 gene in patients with systemic lupus erythematosus(SLE).and to investigate the significance of abnormal expression of DNA methyltransferase in the pathogenesis of SLE.Methods Peripheral blood mononuclear cells(PBMCs)were obtained from 11 patients with SLE and 12 normal human controls.DNA was extracted from the PBMCs.and PCR was performed to amplify some exons(1 to 7)and corresponding introns followed by direct sequencing.Results There was a 21397T/C SNP in the intron 7 between exon 7 and exon 8 of DNA methyltransferase 1 gene in patients with SLE.The frequency of CC homozygote increased in patients with SLE compared with that in normal controls(5/11 vs 1/12,X~2=4.10,P＜0.05).Conclusions There is a 21397T/C SNP in DNA methyltransferase 1 gene in patients with SLE.which may be a component of genetic background underlying the abnormal expression Of DNA methyltransferase 1.

OBJECTIVE:To evaluate the efficacy and safety of dronedarone for atrial fibrillation or atrial flutter.METHODS:The publicly published literatures about the clinical trials on dronedarone for atrial fibrillation or atrial flutter were retrieved from PubMed.The quality analysis of included studies and extraction and cross-check of data were conducted by two reviewers independently using Meta-analysis.Response indexes were tested in tests for heterogeneity and summarized and analyzed using RevMan 5.0.The safety of dronedarone was evaluated.RESULTS:Five RCTs were included.As compared with placebo,dronedarone reduced the hospitalization rate due to cardiovascular events and all-cause mortality(RR=0.76,95%CI=0.72～0.79,P

Objective To evaluate the effect of Caspase-1 inhibitor on hepatic tissue and on the expression of hepatic interleukin-18 of rats with experimental severe acute pancreatitis(SAP).Methods Forty-two SD rats were randomly assigned into 3 groups: healthy control group(HC,n=6),SAP+normal saline group(SAP-S,n=18) and SAP+ICE inhibitor group(SAP-ICE-I,n=18).SAP was induced by retrograde infusion of 4% sodium taurocholate into the pancreaticobliliary duct in SD rats.Animals in HC group received similar surgical procedure and duct cannulation but without sodium taurocholate inoculation.In SAP-S group,rats received the first intraperitoneal injection of isotonic saline 2 hours after induction of acute pancreatitis,and the same injection was repeated at 12th hour.ICE inhibitor was injected into the rats in SAP-ICE-I group 2 hours after induction of acute pancreatitis,and the same injection was repeated at 12th hour.Blood samples were obtained from the rats in SAP-S and SAP-ICE-I groups via cardiac puncture at 6,12 and 18h after modeling,respectively.The levels of serum amylase(AMY),alanine aminotransferase(ALT) and aspartate aminotransferase(AST),and the peritoneal fluid,were detected at these three time points.The histopathology of pancrease and liver were observed under light microscope.Intrahepatic expression and localization of IL-18 protein were detected respectively by Western blotting and immunohistochemistry.Results Serum AMY,ALT,AST and peritoneal fluid were significantly increased in SAP-S and SAP-ICE-I groups compared with those in HC group(P

Objective To study the expression of bivalent DNA vaccine against Schistosoma japonicum in vitro/vivo and lasting time in vivo. Methods The bivalent DNA pVIVO2-SjFABP/Sj23 was transfected transiently into the human embryonic kidney cells of the line 293. RT-PCR was used to detect the expressions of SjFABP and Sj23 mRNA in the 293 cells. Indirect immunofluorescence antibody test(IFAT) was used to detect the expressions of SjFABP and Sj23 proteins. Twelve BALB/c mice were inoculated with pVIVO2-SjFABP/Sj23 via intramuscular injection. Two blood samples were collected from eye sockets and two mice were vivi-perfused each month. This work lasted for 6 months. IFAT was used to detect the expression of proteins in skeletal muscle. Western-blot was used to detect the serum IgG level. Results RT-PCR and IFAT showed the expressions of SjFABP and Sj23 in the HEK-293 cells. IFAT showed SjFABP/ Sj23 was present in vivo at least for 6 months. Special IgG was not detected by Western blot. Conclusions pVIVO2-SjFABP/Sj23, bivalent DNA vaccine, could express correctly in vitro/vivo, and lasts for 6 months at least in vivo.

Objective To investigate the effects of nordihydroguaiaretic acid (NDGA) on the ovary in rats. Methods Forty female SD rats in normal estrous cycles were randomly divided into PBS group and NDGA group, subcutaneously injected of PBS solution and 3% NDGA at the dose of 30 mg/kg respectively every other day for 16 d. The serum concentrations of follicle stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E 2) and progesterone (P) were measured by chemiluminoimmunoassay before and after administration and the mating was confirmed by the occurrence of vaginal plugs and the morphological changes of uterus and ovaries were examined by immunohistochemistry after administration. Results None of the NDGA-treated rats were able to successfully mate as the absence of vaginal plugs were detected. The endometrium could maturate in all of the NDGA-treated rats, but there had a decrease not only in the number of endometrial glands, but also the proliferation rate of the glandular epithelial cells, the endometrial stroma cells, the vessels and the microvacular density (P

By using thrombolysis therapy,34 patients suffering from actue myocardial infarction were treated .And by comparing chromium,cobalt,nickel,vanadium and molybdenum contents in serum of 34 patients suffering from acute myocardial infarction with that of contrast group and the contents between before-treatment and after-treatment,following results were revealed;treatment before chromium,cobalt,nickel,vanadium and molybdenum contents in serum of the patients were low and there is great difference between the patients and control groups(P0 05).

Objective To investigate the effects of nordihydroguaiaretic acid (NDGA) on the embryos growth and decidual development in rats. Methods Fifty pregnant SD rats were randomly divided into NDGA-treated group(N)and control group (P), which were given subcutaneous injection of NDGA or PBS on embryonic day 1(E1), E7 and E14, and then killed on E6 and E9. The number of implantations was calculated, the diameter of the embryos was measured and the numbers and weight of neonates were recorded. The expressions of VEGF, PCNA and FⅧRAg in the deciduas and embryos were detected by immunohistochemistry and then made image analysis. The serum concentrations of progesterone on E9 were measured. Results The number of implantations were decreased with NDGA treatment on E1 (P