OBJECTIVE:To analyze disease burden of antibiotic associated colitis(AAC)in patients with severe traumatic brain injury,and to explore prevention and treatment countermeasures. METHODS:Retrospective analysis method was used to analyze the relationship between the occurrence of AAC in 157 cases of severe traumatic brain injury and application duration,dosage and category of antibiotics. RESULTS:Overuse of antibiotics was closely associated with the occurrence of AAC,especially cephalosporins(P

Objective] To observe the efficacy of acupuncture combined with Chinese herb and conventional treatment for allergic rhinitis. [Method] 272 patients were randomly divided into four groups: Control group, Traditional Chinese Medicine(TCM) group, Acupuncture group, Acupuncture combined TCM group. Patients in Control group received conventional treatment for allergic rhinitis;based on Control group, acupuncture was added in Acupuncture group; based on Control group, TCM was used in TCM group; patients in Acupuncture combined TCM group received both acupuncture and TCM. After treatment, the efficacy of all these groups was analyzed. [Result] The cure rate and total efficiency of Acupuncture combined TCM group, Acupuncture group and TCM group was significantly increased. Compared with the control groups the differences were statistically significant( P<0.05). Among them the therapeutic effect of acupuncture combined TCM group had the best cure rate. Compared to the differences over the TCM group and acupuncture group, the cure rate and total efficiency were statistically significant( P<0.05). [Conclusion] It's important to combine acupuncture together with TCM to improve the clinical efficacy of allergic rhinitis.

It is important and of heavy workload for the client in C/S system to update.According to the actuality of our hospital,this paper suggests three methods and discusses the suitable conditions respectively.These methods have great value in practice.

Objective To explore the role of intracranial electrode EEG monitoring for localizing epileptogenic zone in epilepsy.Methods 20 patients with refractory temporal lobe epilepsy,whose seizure onsets were unable to be localized by MRI、routine EEG and clinical characteristic,accepted long-term intracranial electrode EEG monitoring.Bitemporal lobe subdural implanted trip electrode were used to perform the ictal and interictal EEG monitoring under the guiding of the stereotactic technique.The results routine of EEG,MRI and intracranial electrode EEG were combined.The accuracy for localization of epilepitogenic zone was evaluated based on the followed-up.Results The intracranial electrode EEG monitoring was implanted within 1～5 d.Each patient was recorded the ictal and interictal discharge and was detected clinical onsets at least twice.All patients could be localized by ictal EEG.The consistency between interical EEG and ictal EEG were observated in 15 cases,the inconsistency in 3 cases,and 2 cases were bilateral discharge in interictal.The clinical outcome showed that patients were seizure-free in 13 cases(65%),improved significantly in 3 cases(15%),improved in 3 cases(15%),unimproved in 1 case(5%)according to Engel's criteria after surgery.No significant complication was found in all patients.Conclusion The intracranial electrode EEG monitoring can localize epileptogenic zone and offer reliable evidence for epilepsy surgery.

Objective To investigate the effects of nordihydroguaiaretic acid (NDGA) on the ovary in rats. Methods Forty female SD rats in normal estrous cycles were randomly divided into PBS group and NDGA group, subcutaneously injected of PBS solution and 3% NDGA at the dose of 30 mg/kg respectively every other day for 16 d. The serum concentrations of follicle stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E 2) and progesterone (P) were measured by chemiluminoimmunoassay before and after administration and the mating was confirmed by the occurrence of vaginal plugs and the morphological changes of uterus and ovaries were examined by immunohistochemistry after administration. Results None of the NDGA-treated rats were able to successfully mate as the absence of vaginal plugs were detected. The endometrium could maturate in all of the NDGA-treated rats, but there had a decrease not only in the number of endometrial glands, but also the proliferation rate of the glandular epithelial cells, the endometrial stroma cells, the vessels and the microvacular density (P

Objective To investigate the effects of nordihydroguaiaretic acid (NDGA) on the embryos growth and decidual development in rats. Methods Fifty pregnant SD rats were randomly divided into NDGA-treated group(N)and control group (P), which were given subcutaneous injection of NDGA or PBS on embryonic day 1(E1), E7 and E14, and then killed on E6 and E9. The number of implantations was calculated, the diameter of the embryos was measured and the numbers and weight of neonates were recorded. The expressions of VEGF, PCNA and FⅧRAg in the deciduas and embryos were detected by immunohistochemistry and then made image analysis. The serum concentrations of progesterone on E9 were measured. Results The number of implantations were decreased with NDGA treatment on E1 (P

Objective To investigate the effects of nordihydroguaiaretic acid(NDGA)on the embryos growth and decidualization of rat by intrauterine perfusion and to investigate the new medication for planned parenthood.Methods Fifty-six pregnant SD rats were randomly divided into NDGA-treated group(N)and PBS-treated control group(P)and blank control group(B).By intubation,NDGA or PBS was perfused into the uterus on embryonic day 1(E1)and day 7(E7).Rats were killed on E9 to calculate the number and measure the diameter of the embryos,as well as the number and weight of litters.The expression of VEGF,PCNA and FⅧRAg in deciduas and placenta were detected by immunohistochemistry and image analysis.The serum concentration of progesterone on E9 was measured.Results In comparison with two control groups,the number and the diameter of embryos after perfusion were decreased with NDGA treatment on E1(P0.05).Conclusion NDGA can inhibit the growth of early embryo and interfere with the progress of decidualization obviously by intrauterine perfusion,but has little effect on the serum concentration of progesterone.

[Objective]To evaluate the incidence and predictors of stiff knees after primary TKA.[Method]A retrospective review was given to the data from 1216 patients undergoing primary total knee arthroplasty between October 1996 and October 2006.Forty-five stiff TKA patients with a 1-year postoperative flexion range of less than 90?was taken as treatment group.Forty-five TKA patients with greater than 90? flexion at 1 year postoperative as control group.The age,sex,body mass index,American Society of Anesthesiologists(ASA) rating,surgeon,implant type,and fixation of the control group were matched to those of the treatment group.A case-control study was conducted to determine predictive factors of stiff TKA.[Result]No significant differences were found with regard to the mean age,ratio of sex and preoperative medical comorbidities.Preoperative flexion and intraoperative flexion were predictive of ultimate postoperative flexion(P=0.001 and P=0.039,respectively).Preoperative and postoperative relatively decreased patellar heightwere significantly correlated with postoperative stiffness(P=0.001).[Conclusion]Stiffness post-TKA is multifactorial,careful attention to surgical exposure,restoring gap kinematics,minimizing surgical trauma to the patellar ligament/extensor mechanism,appropriate implant selection,and physiotherapy may all serve to reduce the incidence of post-TKA stiffness.

Objectives To study ho to make an accurate diagnosis of ectopic pregnancy in the early stage through different ultrasonic checking ways, so as to decrease the misdiagnosis and missed diagnosis rates. Methods 195 cases of ectopic pregnancy patients, which were diagnosed by abdominal ultra-sound (TAS) or by vagina ultra-sound (TVS), were collected, then compared with the operational pathological results and anzlyzed the reasons of the misdiagnosis and missed diagnosis, so as to find out the best ultrasonic way. Results 195 cases of ectopic pregnancy patients were diagnosed by ultrasound, the positive coincidence rate was 95.4% (186/195), misdiagnosis rate was 4.1% (8/195) and missed diagnosis rate was 0.5% (only 1 case). Among 186 cases of ectopic pregnancy, which totally conformed to the operational pathological results, 82 cases were pelvic adhesion, 51 cases (62.2%) were diagnosed ectopic pregnancy by TAS. 104 cases were not pelvic adhesion, in which 48(46.2%) cases were diagnosed ectopic pregnancy by TAS, then the significant differences were being shown. Conclusions When in pelvic adhesion, the ultrasonic checking way is mutually related to the positions of the oviduct and ovary in the pelvic cavity. When the oviduct and ovary are pressed close to the anterior abdominal wall, TAS is the best way while they are pressed close to posterior pelvic wall, TVS is the best way. The ultrasonic checking way for ectopic pregnancy is varied upon different patients.It is the main reason of misdiagnosis and missed diagnosis, that the clinical material and dynamic observation were not taken into consideration