Objective:To explore the reversal effect of Docetaxel and Capecitabine on rat breast precancerous from angiogenesis and expression of related regulatory factors VEGF mRNA in rats.Methods: 350 SD rats were divided into 7 groups.Model of rats mammary was induced by DMBA and was treated by Docetaxel and Capecitabine for 4 weeks.All of them were killed from 8th week.The microvascular were detected in the specimens, examination of histopathology was performed and the expression of VEGF mRNA was measured by in situ hybridization.Results:The rat mortality and the incidence of precancerous lesions increased obviously, and the incidence of precancerous lesion of the high-dose group and the middle dose reduced.The positive rate of the expression of MVD,TGF-αand VEGF mRNA tend to increase in all the groups.The positive-cell rate of VEGF mRNA of Docetaxel,Capecitabine, Docetaxel and Capecitabine in ADH was lower than in the model group,and the positive-cell rate of VEGF mRNA of Docetaxel and Capecitabine was lower than Capecitabine and Docetaxel separately.Conclusion: Combination of Docetaxel and Capecitabinecan decrease the expression of VEGF mRNA in precancerouslesion of rats mammary.

BACKGROUND:The success of the preservation of vital pulp in carious deciduous teeth depends not only on determining the health status of the pulp,but also on selecting the most suitable pulp capping agent.At present,the commonly used pulp capping agent materials contain calcium hydroxide preparation and mineral trioxide aggregate (MTA).Recently,new biomaterials,such as Bioaggregate,Biodentine,and TheraCal,with good biocompatibility and good edge sealing,have been developed and extensively used.OBJECTIVE:To compare the efficacies of MTA,calcium hydroxide preparation,Biodentine and TheraCal LC that are commonly used in pediatric dentistry in the preservation of vital pulp in carious deciduous teeth.METHODS:This prospective,single-center,randomized controlled clinical trial will be conducted in Chengdu Maternal and Child Center,China.Children with deep caries of deciduous teeth,who will be scheduled to undergo indirect pulp capping,direct pulp capping,and vital pulpotomy,will be selected and randomized into four groups according to pulp capping agents:MTA group,calcium hydroxide group,Biodentine group and TheraCal group.Patients will receive return visit at postoperative 3,6 and 12 months during follow-up.By using X-ray,we will observe and compare the speed and quality of the formation of the dentin bridge with different biomaterials,and assess the reason for the failure of treatment.This trial was registered in ClinicalTrials.gov identifier:NCT03220360,on July 14,2017.The study protocol has been approved by the Ethics Committee of Chengdu Maternal and Child Center,China (approval number:20170506).All protocols will be performed in accordance with the Ethical Principles for Medical Research Involving Human Subjects in the Declaration of Helsinki.Written informed consent will be provided by each patient and their family members after they indicated that they fully understood the treatment plan.RESULTS AND CONCLUSION:This study will compare the efficacies of various biomaterials in the preservation of vital pulp in carious deciduous teeth.New materials Biodentine and TheraCal will be selected in classical technique to verify their efficacies and explore their superiorities.Classical materials calcium hydroxide and MTA will be selected as controls,which will be separately used in indirect pulp capping,direct pulp capping,and vital pulpotomy to provide reliable choices for clinicians.

Objective: To explore the effects of early higher protein nutrition support and growth hormone in patients with severe craniocerebral injury. Methods: 60 patients with severe craniocerebral injury were randomized into observation group and control group.The observation group (30 cases) had received on higher protein nutrition support [2-2.5 g/(kg?d)] and growth hormone for one week. The control group(30 cases) had received lower [1.2-1.5 g/(kg?d) protein nutrition support] for one week. The levels of protein index were determined. The clinical effect and complication were compared between the two groups. Results: The serum prealbumin, albumin, transferrin and hemoglobin in the observation group were significantly higher than those in the control group.The staying time in ICU was significantly shorter and the progrosis was better in the observation group. There were no statistical differences about the index of liver function, renal function and the morbility between the two groups. Conclusion: Early higher protein nutrition support and growth hormone can improve the nutrition status and the prognosis of patients with severe craniocerebral injury.

Objectives To explore the effects of follow-up health edueation of cardio-vascular patients outside hospital on their compliance with doctor's advices.Methods Eighty cardio-vagcular patients were selected and divided randomly into the control group and the follow-up group with 40 cases in each group.The patients of the control group were siren instmcfons only before leaving hospital while those of the follow-up group received follow-up health education as well as the leaving-hospitsl insuuctions.Investigations were carried out one year after follow-up health education in the two groups' compliance with doctor's advices including their thempeutic changes of lifestyle,re-admittance to hospital and mortality.Results Signitlcant differences were found between the follow-up gtonp and the control group in respect of the pationts' compliance with doctor's advices,re-admittance to hospital and mortality,P＜0.01,P＜0.05.The complialice with doctor's advices in the follow-up group Wag obviously better than that of the control group.Conclusions The follow-up health education can be an effective way for promoting the cardio-vascular patients' compliance with doctor's advice after leaving hospital.

Objective: To study the effect of active attention with/without target counting on event-related potentials (ERPs) Method: ERPs were elicited by non-target (750 Hz, 80%) and target (2000 Hz, 20%) stimuli in an auditory oddball paradigm for 18 healthy young subjects Results:Compared to the active attention with target counting manner, P3 amplitude was significantly smaller when without target counting (P

0.05). Significant differences of post-operative VA, time of retinal detachment, and neurepithelial thickness were found (P0.05). Conclusions The time of retinal detachment and post-operative VA in patients with retinal detachment relate to the neurepithelial thickness detected by OCT. When the duration of retinal detachment becomes longer, the macular neurepithelium becomes thicker, the histomorphological changes increase, and the post-operative VA decreases.

Human bocavirus 1 ( HBoV1 ) is closely related to lower respiratory infections in children. Respiratory symptoms elicited by HBoV1 include cough, tachypnea, wheezing and dyspnea, which are of mild degree and haven′t found to be distinguished. Few single infected patients with dyspnea needing mechanical ven-tilation were reported,however,the number of severe cases caused by HBoV1 is increasing in recent years. Here we reviewed the epidemiological characteristics, clinical manifestations, treatment and prognosis of HBoV1 in-duced severe lower respiratory infections.

Objective To observe the effects of multidisciplinary therapy on central pain of patients with spinal cord injury.Methods 32 cases of spinal cord injury with central pain were treated with accupuncture, massage and drugs, and the effects were assessed by McGill Pain Questionnaire (MPQ), Visual Analogous Score (VAS) and Barthel Index (BI).Results The scores of pain of all patients significantly decreased and the scores of BI highly increased after treatment (P<0.01).Conclusion Multidisciplinary therapy is effective on central pain in patients with spinal cord injury.

Objective To investigate the application of quality control cycle activity in reducing thedisquali-fication rate of bowel preparation for colonoscopy outpatients.Methods Set up a group of quality control circle,and select the issues that reducing the disqualification rate of bowel preparation for colonoscopy outpatients as the activity theme.According to the activity steps of quality control circle,the activity was carried out.The causes of disqualifica-tion rate of bowel preparation were analyzed and the countermeasures to improve and implement were implemented. Also,the disqualification rates of bowel preparation before and after quality control circle were compared.Results The disqualification rate of bowel preparation was reduced from 39.09% to 14.03% after quality control circle activi-ty.The difference was statistically significant(χ2 =53.65,P <0.01).Target success rate was 104.42%,and the pro-gress rate was 64.11%.Conclusion The quality control circle activity can effectively reduce the disqualification rate of bowel preparation for colonoscopy outpatients,thereby improve the quality of diagnosis and treatment,and reduce the economic burden of patients.After clear improvement of focus,the leading causes of disqualification bowel prepa-ration are obtained through characteristic diagram (figure 2)analysis.Also,true causes are validated based on the three principles.The four true causes final defined include short contact time nurses and patients,large liquid dosage, none nursing intervention outside hospital,and chronic constipation without intervention.

Objective　To evaluate the effectiveness of intratracheal tube suctioning by respiratory mechanics measurement.Methods　The indexes of respiratory mechanics,including respiratory rate,expiratory tidal volume,% leak around the tube,dynamic respiratory compliance and mean airway resistance were measured just before and 20 minutes after intraendotracheal tube suction in mechanical ventilated children with respiratory failure.Results　Fifty-two measurements was carried out in 11 patie nts.The mean values of respiratory risistance was (116.73±27.12)cmH2O/L.s before suctioning and (93.38±26.64)cmH2O/L.s after suctioning,with significant differrence(P＜0.01)；The mean values of % leak around the tacheal tube dereased from(18.12±4.12)% before suctioning to (8.71±3.76)% after suctioning (P＜0.05),The mean values of expiratory tidal valume was markedly increased from(7.31±2.12)ml/kg before suctioning to(5.72±1.2)ml/kg after suctioning(P＜0.01),The total respiraory rate markedly decreased after suctioning.Conclusion　The respiratory mechanics measurement is very useful to evaluate the airway patient.The removal of secretions is crucial in respiratory managemet.