Genetic researches have been paid more attention in dentistry area recent years;however,researches mainly focus on the tooth specific genetic diseases.In this review,we review the detailed genetic syndromes which are related with abnormal enamel and dentin.We wish this review will be helpful to those who are interested in oral genetic research.

Our army medical morals was engendered and developed along with our army medical treatment work.This text is tight and tight hold the "a thought","twice important history affairs","two standard points"and "a slogan",tally up developments experience of the Land Revolution,expatiated process and the basically composition of the mode.

CYP2C9 is an important enzyme of drug metabolism expressed in liver, It can metabolize several clinically important drugs, some with a low therapeutic index. This review summarizes the CYP2C9 gene structure, induction mechanism, known polymorphism and functional significances and their population frequencies.

Dental Research ; Humans ; Mouth Diseases ; genetics ; Research Design

Computational Biology ; Genetic Diseases, Inborn ; Humans ; Mouth Diseases ; genetics

Genetic Research ; Humans ; Mouth Diseases ; genetics ; Rare Diseases ; genetics

Craniofacial Abnormalities ; Humans

Dental Enamel ; Hardness ; Humans ; Tooth Diseases ; genetics

Genetic Diseases, Inborn ; diagnosis ; Humans ; Mouth Diseases ; diagnosis ; genetics

Objective: To study the phenotype characteristic of mandibular condylar chondrocytes (MCCs) in vitro. Methods: MCCs of two-week-old New Zealand rabbits were isolated with enzyme digestion and cultured in DMEM. Phase contrast microscopy, image analysis system, MTT assay and immunocytochemistry method were used to compare MCCs of different passages in cellular shape and size, growth curve and expression of type I and type II collagen. Results: The majority of MCCs in earlier passages (1～3 passage) were polygonal, while more fusiform and spindle-shaped cells were found after 5～6 passages. MCCs in earlier passages were smaller than those in sixth passages. The proliferation rate of MCCs decreased with passaging. There were more type II collagen positive cells in 1 ～ 3 passages, while more type I collagen positive cells in 7th passage. Conclusion: The changing characters of MCCs in vitro such as cellular shape and size and expression of type I and II collagen are similar to those of MCCs in vivo from proliferating zone to hypertrophic zone. MCCs in later passages may be with dedifferentiation.