OBJECTIVE:To evaluate the practice of the Guidelines for Clinical Use of Antibacterials in our hospital. METHODS: 200 medical records of pediatric inpatients who had been discharged from our hospital were randomly sampled between June to December in 2003 (before intervention) and between June to December in 2005 (after intervention) for a statistical analysis in respect of the use of antibacterials in which the pre-designed questionaire on the contrast analysis of clinical application of Antibacterials were filled. RESULTS: After the introduction of the guidelines, the rate of using antibacterials decreased by 17.50%, the rate of combined use of antibacterials decreased by 32.10%, the rate of rational use increased by 22.05%, the rate of susceptibility test increased by 11.84%. The Drug Utilization Index for all the antibacterials was no more than 1 (≤1). CONCLUSION: The use of antibacterials in pediatric inpatients in our hospital tends to be rational, but the rational administration of antibacterials remains to be further improved.

OBJECTIVE:To study the correlation between the usage and dosage of inhalations and the adverse drug reactions and the effect of pharmacetical care. METHODS:Aimed at the usage and dosage of inhalations,intervention was adopted in drug use of patients. RESULTS:The occurrence of the adverse drug reactions of inhalations was associated with patients' poor knowledge about correct usage of drugs. CONCLUSION:Clinical pharmacists' intervention on patients' use of inhalations achieves satisfactory outcome.

[ABSTRACT]OBJECTIVETo investigate the safety of the head and neck muscle pedicle flap or flaps with single vascular pedicle.METHODSThe characteristics of thoracoacromial artery were investigated in 20 autopsy cases. Farthest point into the muscle were checked by preoperative ultrasonography and intraoperative localization with perspective observation, the muscles 1-2 cm above the farthest point were cut off from the donor site, forming a simple arteriovenous island flap pedicled pectoralis major muscle. Using the same technology and methods, sternocleidomastoid island and lower trapezius island flap were harvested.RESULTSAnatomical observation revealed thoracoacromial artery single type accounts for 12.5% (5/40), double vessel type 67.5% (27/40), multiple vessel type 20% (8/40). The rate of furthest point localization with preoperative ultrasound was 29.1% (14/48), the DSA successfully developed breast artery perforator in 66.7% (12/18) of the cases. Forty eight pectoralis major island muscle flaps, 12 internal mammary artery flaps, 18 chin flaps, 4 lower trapezius island myocutaneous flaps, 4 sternocleidomastoid island myocutaneous flaps, 3 transverse cervical artery island shaped flaps, 3 thoracoacromial artery perforator island flaps were harvested. Two flaps were failure. Partial necrosis occurred in 3 pectoralis major myocutaneous flaps.CONCLUSIONThe design of single vascular pedicle island flap for the head and neck defects is feasible and safe, and patients benefite not only for easily shaped the island flap, but also for the region appearance and function preservation in both the donor site and recipient site.

Objective To find out about the risk factors and prevention and treatment measures for complication with hospital infection in patients with primary nephrotic syndrome. Methods An analysis was conducted by means of retrogressive survey of the relevant clinical data on 146 cases of patients with primary nephrotic syndrome. Results The rate of hospital infection in patients with primary nephrotic syndrome reached 35 6%, with the respiratory tract being the main infected site(46 4%) and the urinary tract being the next major infected site(17 9%); the rate of infection is related to such factors as length of stay(P

The paper gives a comprehensive account of the current situation of SARS treatment and analyzes the features of the disease and its prevention and treatment, viz. SARS treatment has been conducted without RCT studies; the life quality of cured SARS patients has lowered; there is the possibility of repeated SARS outbreaks and spread; and the effectiveness of some therapeutic regimes needs to be ascertained. For this reason, it is suggested that evidence-based medicine be used in screening therapeutic regimes for SARS and that systematic assessments and standardizations be conducted so as to work out favorable regimes for SARS treatment and make efficient use of limited health resources.

Objective:To observe clinical therapeutic effect of Xiaoshuan Yizhi Capsules on multiple infarctional dementia(MID).Methods:50 cases of MID were randomly divided into Xiaoshuan Yizhi Capsules treatment group and Hydergine control group.Their symptoms and signs,cumulative scores of Haseguwa's Dementia Scale(HDS)and Mini-mental state examination(MMSE),blood lipids,hemorheologic indexes,superoxide dismutase(SOD)activity in red cells,plasma lipids of peroxide(LPO)content were investigated. Results:The total effective rate was 90% in the treatment group,and Xiaoshuan Yizhi Capsules not only improved symptoms and signes,increased cumulative scores of HDS and MMSE,and also regulated blood lipids,decreased hemorheologic indexes,raised SOD activity and decreased LPO content.Conclusion:Xiaoshuan Yizhi Capsule is superior to Hydergine in treatment of MID.

OBJECTIVE:To optimize the extract technology for Plumula Nelumbinis.METHODS:Four methods:water extraction(WE),water extraction by precipitation with alcohol(WAE),semi-bionic extraction(SBE),and semi-bionic ex-traction by precipitation with alcohol(SBAE)were used to extract Plumula Nelumbinis and also compared in their effects by adopting the total content of alkaloid and the yield of dry extract as markers.The comprehensive values Y was calculated.RESULTS:Through the comprehensive evaluation of the two markers,the comprehensive values Y ranked in the order of SBE,WE,SBAE and WAE.CONCLUSION:SBE method is the optimal method to extract Plumula Nelumbinis.

It is reported that anisodamine exhibited cell protection action during anoxia and ischemia, the mechanism of which is still obscure. Present study found that: (1) 654-2 significantly reduced the reperfusion mucosal damage of ischemic intestines and the accumulation of intracellular calcium; (2) anisodamine could blunt the contraction of the high potasium depolarized guinea pig ileum with calcium; (3) intermittent injections of 5mg/kg 654-2 significantly inhibited the cardiac function.The above results suggest that 654-2 possesses calcium-antagonist action, which may be one of the chief mechanism of its cell protection action.

The role of neutrophil in the pathogenesis of many diseases attracts more attentions than before. Neutrophil elastase (NE), a powerful neutrol proteinase capable of causing major tissue destruction in many diseases, is mainly present in the azurophil granules of neutrophil. A solid-phase enzyme-linked immunosorbent-biotin assay for human NE has been developed. Only 20?l of plasma sample is needed. Non-smoking healthy adults have 33.7?6.7ng NE/ml plasma; patients with chronic obstructive pulmonary diseases, 48.0+ 10.9 ng NE/ml; patients with pyogenic dermatisis, 69.1?15.7 ng NE/ml; patients with systemic lupus erythematosus, 61.0?13.9 ng NE/ml; patients with aplastic anemia, only 12.3?5.3 ng NE/ml. All of these results have significant differences compared with the result of healthy adults. The results of assay showed that this quantitative assay with good specificity and accuracy may be a better criterion for investigating the effect of NE on pathogenesis of some diseases.

Objective To investigate the effect and safety of Qizheng Qingpeng ointment in the treatment of eczema.Methods Ninety -eight patients of eczema were randomly divided into two groups, who received either Qizheng Qingpeng ointment plus hydrocortisone butyrate cream or only hydrocortisone butyrate cream at the first 2 weeks,and all patients were treated of Qizheng Qingpeng ointment plus hydrocortisone butyrate cream at the further 2 weeds.Results At 1 week and 2 week post-treatment,the efficacy rates were 68.52%,87.03% for the study groups and 27.91%,58.13%for the control groups,the efficacy rate of the study groups was statistically better than that of the control groups (χ2 =14.21,8.99, all P<0.01 );At 4 week post -treatment, the efficacy rates were 94.44%for the study groups and 90.70%for the control groups,the difference of the efficacy rates in the two groups were no statistically significant (χ2 =0.11,P>0.05) .Conclusion The clinical efficacy of Qizheng Qingpeng oint-ment associated with corticosteriod for treatment of eczema was better than corticosteriod alone.