1.Effects of Radix Salviae Miltiorrhizae on the proliferation of vascular smooth muscle cells induced by plateletderived growth factor
Chinese Journal of General Surgery 2001;0(08):-
ObjectiveTo determine the effects of Radix Salviae Miltiorrhizae (RSM) on the proliferation of vascular smooth muscle cells(SMC) induced by plateletderived growth factor(PDGF).MethodsRat arterial SMC cultured in vitro were divided into the control group, RSM group (subdivided into 3 concentration groups:2.0mg/ml, 0.4mg/ml and 0.08mg/ml),PDGF group(10ng/ml) and PDGF(10ng/ml) plus RSM (the 3 concentrations the as the same as above) group. The number of SMC and 3HTdR incorporation of SMC were measured. Results PDGF induced the increases of the number of SMC and 3HTdR incorporation of SMC significantly, which were as 3fold and 2.5fold as those of the basic situation respectively. RSM,which was dosedependent, inhibited the increase of the number of SMC and 3HTdR incorporation of SMC in the basic and PDGF stimulated situations . ConclusionsRSM may inhibit SMC proliferation in the basic and PDGF stimulated situations.
2.The application of laparoscopic total mesorectal excision with preservation of anal sphincter for rectal cancer
Chaojun ZHANG ; Ping LLANG ; Yunsheng LUO ; Xiaogan MA ; Yingdong CHENG ; Liming WANG ; Jiamei XIANG
Chinese Journal of General Surgery 2000;0(12):-
Objective To explore the feasibility and efficacy of laparoscopic total mesorectal excision(TME) with preservation of anal sphincter for rectal cancer.Methods From October 2001 to March 2004,54(patients) with rectal cancer underwent laparoscopic total mesorectal excision(TME) with preservation of anal sphincter.In 51 of the 54 cases,the operation was completed laparoscopically,including 14 cases of(laparoscopic) anterior resection(AR) with the anastomosis level above the peritoneal reflection;20 cases of laparoscopic low anterior resection(LAR) with the anastomosis level more than 2cm above the dentate line;16 cases of laparoscopic ultralow anterior resection(ULAR) with the level of anastomosis within 2cm of the dentate line;and 2 cases of laparoscopic coloanal anastomosis(CAA) with the level of the anastomosis at or below the dentate line.whereas conversion to an open approach was required in three cases.Results The average operating time was 145 minutes(range 110~210min),and mean operative blood loss was 50 mL(range 30~80mL).Bowel function was restored and diet was resumed at 48 to 36 hours after operation.The average hospital stay was 9 days(range 7~14d).TME was completed successfully in 51 patients.Postoperative analgesics were used in 20 patients.No intraoperative or postoperative complications were(observed).Follow-up time was from 6~36 months in 51 patiebts,and there was no port-site or local tumor recurrence.Conclusions Laparoscopic TME is feasible and safe.It is a perspective technique with the(benefits) of minimally invasive technique and lower blood loss during operation,and rapid recovery.
3.Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province.
Kui LIU ; Yuan-Yuan FANG ; Yan DENG ; Wei LIU ; Mei-Fang WANG ; Jing-Ping MA ; Wei XIAO ; Ying-Nan WANG ; Min-Hua ZHONG ; Cheng-Hong LI ; Guang-Cai LI ; Hui-Guo LIU
Chinese Medical Journal 2020;133(9):1025-1031
BACKGROUND:
The 2019 novel coronavirus (2019-nCoV) causing an outbreak of pneumonia in Wuhan, Hubei province of China was isolated in January 2020. This study aims to investigate its epidemiologic history, and analyze the clinical characteristics, treatment regimens, and prognosis of patients infected with 2019-nCoV during this outbreak.
METHODS:
Clinical data from 137 2019-nCoV-infected patients admitted to the respiratory departments of nine tertiary hospitals in Hubei province from December 30, 2019 to January 24, 2020 were retrospectively collected, including general status, clinical manifestations, laboratory test results, imaging characteristics, and treatment regimens.
RESULTS:
None of the 137 patients (61 males, 76 females, aged 20-83 years, median age 57 years) had a definite history of exposure to Huanan Seafood Wholesale Market. Major initial symptoms included fever (112/137, 81.8%), coughing (66/137, 48.2%), and muscle pain or fatigue (44/137, 32.1%), with other, less typical initial symptoms observed at low frequency, including heart palpitations, diarrhea, and headache. Nearly 80% of the patients had normal or decreased white blood cell counts, and 72.3% (99/137) had lymphocytopenia. Lung involvement was present in all cases, with most chest computed tomography scans showing lesions in multiple lung lobes, some of which were dense; ground-glass opacity co-existed with consolidation shadows or cord-like shadows. Given the lack of effective drugs, treatment focused on symptomatic and respiratory support. Immunoglobulin G was delivered to some critically ill patients according to their conditions. Systemic corticosteroid treatment did not show significant benefits. Notably, early respiratory support facilitated disease recovery and improved prognosis. The risk of death was primarily associated with age, underlying chronic diseases, and median interval from the appearance of initial symptoms to dyspnea.
CONCLUSIONS
The majority of patients with 2019-nCoV pneumonia present with fever as the first symptom, and most of them still showed typical manifestations of viral pneumonia on chest imaging. Middle-aged and elderly patients with underlying comorbidities are susceptible to respiratory failure and may have a poorer prognosis.
Adult
;
Aged
;
Aged, 80 and over
;
Betacoronavirus
;
China
;
Coronavirus Infections
;
complications
;
diagnostic imaging
;
Female
;
Fever
;
etiology
;
Humans
;
Male
;
Middle Aged
;
Pandemics
;
Pneumonia, Viral
;
complications
;
diagnostic imaging
;
Tertiary Care Centers
;
Tomography, X-Ray Computed
;
Young Adult
4. Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province
Kui LIU ; Yuan-Yuan FANG ; Yan DENG ; Wei LIU ; Mei-Fang WANG ; Jing-Ping MA ; Wei XIAO ; Ying-Nan WANG ; Min-Hua ZHONG ; Cheng-Hong LI ; Guang-Cai LI ; Hui-Guo LIU
Chinese Medical Journal 2020;133(0):E002-E002
Background:
A novel coronavirus (2019-nCoV) causing an outbreak of pneumonia in Wuhan, Hubei province of China was isolated in January 2020. This study aims to investigate its epidemiological history, and analyzed the clinical characteristics, treatment regimens and prognosis of patients infected with 2019-nCoV during this outbreak.
Methods:
Clinical data from 137 2019-nCoV-infected patients admitted to the respiratory departments of nine tertiary hospitals in Hubei province from December 30, 2019 to January 24, 2020 were collected, including general status, clinical manifestations, laboratory test results, imaging characteristics, and treatment regimens.
Results:
None of the 137 patients (61 males, 76 females, aged 20-83 years, mean age 55 ± 16 years) had a definite history of exposure to Huanan Seafood Wholesale Market. Major initial symptoms included fever (112/137, 81.8%), coughing (66/137, 48.2%), and muscle pain or fatigue (44/137, 32.1%), with other, less typical initial symptoms observed at low frequency, including heart palpitations, diarrhea, and headache. Nearly 80% of the patients had normal or decreased white blood cell counts, and 72.3% (99/137) had lymphocytopenia. Lung involvement was present in all cases, with most chest computed tomography scans showing lesions in multiple lung lobes, some of which were dense; ground-glass opacity co-existed with consolidation shadows or cord-like shadows. Given the lack of effective drugs, treatment focused on symptomatic and respiratory support. Immunoglobulin G was delivered to some critically ill patients according to their condition. Systemic corticosteroid treatment did not show significant benefits. Notably, early respiratory support facilitated disease recovery and improved prognosis. The risk of death was primarily associated with age, underlying chronic diseases, and median interval from the appearance of initial symptoms to dyspnea.
Conclusions
The majority of patients with 2019-nCoV coronavirus pneumonia present with fever as the first symptom, and most of them still showed typical manifestations of viral pneumonia on chest imaging. Middle-aged and elderly patients with underlying comorbidities are susceptible to respiratory failure and may have a poorer prognosis.