Surgery is an important way to treat patients with primary hyperparathyroidism.Recently,conventional bilateral neck exploration is substituted with minimal invasive surgeries gradually due to the development of the technology of pre/intro-operative localization.Video-assisted surgery is one of the minimal invasive surgeries.It includes video-assisted parathyroidectomy and total endoscopic parathyroidectomy.This article summarize the literatures of treatment of primary hyperpatathyroidism with video-assisted surgery in this article.

Objective To optimize the extraction process of Zushima Gel Cream.Methods Setting the content of daphnetin as an investigating index, and the amount of solvent, soak time and the extraction time as investigating factors, the orthogonal experiment was used to optimize the extraction process.Results The best extraction process was as follows:adding 30 mL water to degreasing Zushima Gel Cream;soaking for half an hour;extracting one time for two hours. The average content of daphnetin was 9.83 mg/g.Conclusion The extraction process is stable, reliable, and energy-saving. The study provided experimental evidence for the preparation process of Zushima Gel Cream.

AIM:To establish an effective and convenient method for applying HPLC fingerprints to quality control in the production of Shanzhuang Jiangzhi Tablet(Semen cassiae,Fructus crataegi,and Folium nelumbinis).METHODS:DiamonsilTM C18(150 mm?4.6 mm,5 ?m) analytical column was used and eluted with a gradient program consisted of phase B(methanol) and phase D(1% phosphoric acid) and detected at 254 nm;the column temperature was 30 ℃.The flow rate was 1.0 mL/min.RESULTS:Ten batches of sample tablets were tested and gained HPLC fingerprint of the tablet containing 17 common peaks.CONCLUSION:This validated method is available for quality evaluation and quality control in Shanzhuang Jiangzhi Tablet.

OBJECTIVE:To evaluate the utilization status and trend of anti-vomiting drugs in our hospital. METHODS: The anti-vomiting drugs used in our hospital during the 2001～2006 were analyzed statistically in respect of drug kinds, dosage forms, consumption sum, DDDs etc. RESULTS: Both the drug kinds and the consumption sum of anti-vomiting drugs increased year by year in our hospital over 6 years, dominating the first place was 5-HT3 antagonists, of which, Ondansetron topped the list in consumption sum for five years and its DDDs ranked at the first place for 4 years. Domestic injections took the lead among all the anti-vomiting drugs. CONCLUSION: Consumption quantity of 5-HT3 antagonists has a rapid increase and which occupy a dominate place in our hospital.

AIM:To establish an effective and convenient method for applying HPLC fingerprints to quality control in the production of Shanzhuang Jiangzhi Tablet(Semen cassiae,Fructus crataegi,and Folium nelumbinis).METHODS:Diamonsil~(TM) C_(18)(150 mm×4.6 mm,5 μm)analytical column was used and eluted with a gradient program consisted of phase B(methanol)and phase D(1 % phosphoric acid)and detected at 254 nm;the column temperature was 30℃.The flow rate was 1.0 mL/min.RESULTS:Ten batches of sample tablets were tested and gained HPLC fingerprint of the tablet containing 17 common peaks.CONCLUSION:This validated method is available for quality evaluation and quality control in Shanzhuang Jiangzhi Tablet.

Objective To study the automatic word segmentation scheme suitable for traditional Chinese medical record literature. Methods Hierarchical Hidden Markov Model was used as segmentation model. Totally 300 ancient medical record literature and 300 modern medical record literature were set as experimental subjects to establish the dictionary of traditional Chinese medicine and the test corpus, with a purpose to segment the words and evaluate of the results. Results Without using dictionary of traditional Chinese medicine, the word segmentation accuracy of two kinds of medical record literature was about 75%;the part-of-speech tagging accuracy of ancient medical literature was 56.74%, the modern medical literature accuracy was 64.81%. By using dictionary of tradition Chinese medicine, the word segmentation accuracy of ancient medical record literature was 90.73%, the modern medical record literature accuracy was 95.66%;the part-of-speech tagging accuracy of ancient medical record literature was 78.47%, the modern medical record literature accuracy was 91.45%, which was obviously higher than that of ancient medical record literature. Conclusion The current word segmentation scheme has initially solved the problem of word segmentation of traditional Chinese medical record literature and part-of-speech tagging of modern medical record literature. Part of speech tagging is basically correct, but part-of-speech tagging of ancient medical record literature tagging needs further study for many influencing factors.

Clinical trials are important means to push forward the development of human health. Every new drug needs to under-take clinical trials eventually to determine the efficacy and safety. In the paper, through our clinical trial experiences and extensive lit-erature retrieval, some problems of the communication management in clinical trials were analyzed and relevant countermeasures were suggested to improve the communication management in clinical trials in order to help the development of clinical trials.

Phage display technology describes a genetic engineering technique in which a library of peptide or protein variants is expressed on the outside of a phage virion,while the genetic material encodes each variant resides on the inside and maintains the relatively independent spatial structure and biological activity. Studies have shown that the phage display technology can be used to screen tumor homing peptides,target trans-porting anti-substances,develop vaccines,research diagnostic regents and image in blood vessels.Thus phage display technology is a powerful method to overcome the challenge of tumor disease.

0.05).CONCLUSION:This is an improved method to extract BMSCs primarily,which is more economical,easier to operate.

Objective To prepare Paracetamol (APP) multiloculated implant loaded with poly-lactide-co-glycolide acid (PLGA) and to study the drug release profile in vitro. Methods APP multiloculated implant was fabricated by micro-electro-mechanical system (MEMS), and high-performance liquid chromato graphy (HPLC) measurement was used to investigate in vitro drug release profile. HPLC analysis was carried out by employing C18 column and a mixture of methanol-water (15∶85) as mobile phase. The detection wavelength was 215nm and flow rate was 0.8mL/min. Results With different multiloculated shape, the rate of the drug release in vitro was varied significantly. Moreover, the releasing of APP multiloculated implant with ecto-tetragonum ento-hexagon in vitro conformed to Higuchi equation. Conclusion The technology of the preparations is feasible, and the structural and morphological characteristics of the multiloculated implant have a significant impact on the release speed of the drug delivery system.