Objective:To summarize the development and characteristic of the anesthesia management of the High Intensity Focused Ultrasound therapy.Methods:1 248 cases from 1999 to 2006 were analyzed retrospectively about the anesthesia management of the High Intensity Focused Ultrasound therapy.Results:Traditional anesthesia management were taken in the most cases:About the tumors at the upper limb,chest,epigastric zone,general anesthesia with tracheal intubation was taken in the most cases,at the kidney,uterus,ovaries and lower limbs,continuous epidural anesthesia was taken.Conclusion:General anesthesia with tracheal intubation is a safe and effective style for the therapy,which makes for the stabilization of the hemodynamics,sufficient oxygen supply,consummate analgesia,sedation and musle relaxation,and ensures the comfortable and security of the patients.

Objective To summarize CT manifestation of atypical brain injuries . Methods The data of 14520 patients with brain injury who have examined by CT scan were collected from1996～2002. Thin slice and HRCT were performed in interested region.Of them,53 cases are diagnosed as delayed or atypical brain injuries. Results In 17 cases of brain contutions , high density punctate lesion(9 cases), and patchy low-dense areas(8 cases)were showed on CT. In 36 cases of delayed brain injuries, CT showed cerebral edema(9 cases),axonal injuries(7 cases), scattered micro-hematoma(5 cases), and delayed subdural hematoma (15 cases).Conclusion CT scan is of important value in dignosing brain injury. We should play much attention to the atypical CT manifestations of brain trauma , and reexamination has great sense to old age patients especially.

Objective To investigate the effects of low dose testosterone on heart function,and ventricular remodeling in male rats with postinfarction congestive heart failure(CHF).Methods Sixty SD rats were undergone surgery,of which,45 rats were performed coronary artery ligation and other 15 were sham group (PS group).Six weeks later,left ventricular function of survived rats was examined by echocardiography,and LVEF≤45％ was defined as the standard of successful CHF model.All survived model rats were randomly divided into 2 groups:TU group(n =16) treated with TU 5 mg/kg per 2 weeks intramuscular injection;placebo (PL) group (n =16) treated with PL.Mter treatment for 12 weeks,left ventricular ejection fraction(LVEF) was assessed by echocardiography again.Serum testosterone level was determined by radioimmunoassay.The expression of tumor necrosis factor-or (TNF-α) mRNA and matrix metalloproteinase (MMP)-9mRNA in myocardial tissue was measured by RT-PCR.Results In male post-myocardial infarction rats,serum testosterone level and LVEF were decreased significantly than PS group(P ＜ 0.05),and the expression of TNF-α mRNA and MMP-9 mRNA in myocardial tissue was increased significantly than PS group (P ＜ 0.05).Mter low dose TU therapy,LVEF of rats in TU group improved significantly(P ＜0.05),and the expression of TNF-α mRNA and MMP-9 mRNA in myocardial tissue was reduced significantly (P ＜ 0.05).Meanwhile,the mortality was decreased (P ＜ 0.05).Conclusion Low dose testosterone therapy can restore the inflammatory imbalance and suppress the ventricular remodeling in male post-myocardial infarction rats and improve left ventricular function,as well as reduce mortality.

Objective:To establish a method for the determination of atorvastatin and amlodipine in compound atorvastatin calcium and amlodipine besylate tablets. Methods:The determination was performed on a Gemini-NX C18 column (250 mm × 4. 6 mm, 5μm) with the mobile phase consisting of 20 mmol·L-1 potassium dihydrogen phosphate solution ( adjusting pH to 4 with phosphoric acid)-acetonitrile-methanol (30 ∶10 ∶60) at a flow rate of 1. 0 ml·min-1 . The detection wavelength was set at 240 nm and the column tem-perature was 30℃. The injection volume was 20μl. Results:The linear range of atorvastatine and amlodipine was 0. 4-40. 0μg·ml-1 and 0. 2-20. 0 μg·ml-1, respectively. The mean recovery of atorvastatin and amlodipine was 100. 6% and 99. 7%, and RSD was 0. 92% and 0. 85% (n=9), respectively. Conclusion:The method is special, stable and reliable, and can be used for the content determination of compound atorvastatin calcium and amlodipine besylate tablets.

Objective To explore the clinical effect of Haizhu-Chuanxidingtablet with MORA-super bio-resonance in bronchial asthma.Methods A total of 94 patients met the inclusion criteria in our hospital were divided control group and observe group by a random way, 47 in each group. The control group was treated with MORA-super bio-resonance while the treatment group withHaizhu-Chuanxiding tablet on the base of control group. The treatment time was 50 days in the 2 groups. After the treatment, the effects in the 2 groups were compared. Before and after the treatment, the levels of lung function (FVC, PEF, FEV1% and FEV1), inflammation index (hs-CRP, IL-8,TNF-α and IL-4), matrix metalloproteinase-9 (MMP-9), tissue inhibitors of metalloproteinase 1 (TIMP-1), toll like receptor 2 (TLR2) and eosinophil cationic protein (ECP) were detected in the 2 groups.Results After the treatment, the effect rate was 91.5% (43/47) in the observe group, significantly higher than 72.3% (34/47) in the control group (Z=4.201,P=0.037). After the treatment, the levels of FVC (2.45 ± 0.37 Lvs.1.93 ± 0.32 L,t=3.561), PEF(6.16 ± 1.25 L/svs. 5.56 ± 1.10 L/s,t=3.413), FEV1/FVC (68.39% ± 6.44%vs. 62.31% ± 5.97%,t=3.315) and FEV1 (2.61 ± 0.56 Lvs. 2.21 ± 0.47 L,t=3.672) in the observe group significantly higher than the control group (P<0.05). After the treatment, the levels of hs-CRP (8.14 ± 0.42 mg/Lvs. 12.41 ± 0.65 mg/L,t=3.424), IL-8 (113.47 ± 11.13 ng/Lvs. 153.81 ± 19.73 ng/L,t=3.692), TNF-α (0.31 ± 0.04 ng/Lvs. 0.70 ± 0.13 ng/L,t=3.923)], IL-4 (39.43 ± 6.23 ng/Lvs. 47.75 ± 8.23 ng/L, t=3.783) in the observe group significantly lower than the control group (P<0.05). After the treatment, the levels of MMP-9 (84.89 ± 9.19 ng/mlvs. 113.35 ± 11.35 ng/ml,t=3.671), TIMP-1 (91.53 ± 8.78 ng/mlvs. 131.15 ± 12.45 ng/ml,t=3.782), ECP (19.43 ± 1.33 ng/Lvs. 25.75 ± 2.13 ng/L,t=3.561) in the observe group significantly lower than the control group (P<0.05). The level of TLR2 (270.31 ± 7.01 ng/Lvs. 198.70 ± 10.13 ng/L;t=3.871,P=0.038) in the observe group significantly higher than the control group (P<0.05).ConclusionsHaizhu-Chuanxidingtablet with MORA-super bio-resonance in bronchial asthma showed a good effect on patients with bronchial asthma and could promote the inflammation and lung function in patients.

Objective To investigate the preventive role of somatostatin in acute pancreatitis and hyperamylasemia induced by endoscopic retrograde cholangiopancre aticography (ERCP) in different periods .Methods 570 cases were divided into four groups , the preoperative group(127 cases) ,the postoperative group(153 cases) ,the whole group(189 cases) and the control groups(101 ca-ses) ,and occurrences of acute pancreatitis and hyperamylasemia were observed .6 h before the operation ,the preoperative group was given 3 mg somatostatin per 12 h by microdosis venous pump .In 12 h after the operation ,the postoperative group was given 3 mg somatostatin per 12 h by microdosis venous pump ,the whole group was given somatostatin 6 h before and 12 h after the operation , the control group was injected normal saline .Measurement of hyperamylasemia was made in 24 h after ERCP ,and clinical manifes-tations of acute pancreatitis were also observed .Results The incidences of PEP and hyperamylasemia were 4 .04% ,23 .86% ,re-spectively .The incidences of hyperamylasemia among the four groups were 23 .62% ,21 .57% ,13 .23% and 47 .52% ,and the inci-dences of PEP were 3 .15% ,4 .58% ,1 .59% ,8 .91% .The incidences of hyperamylasemia and PEP in somatostatin used groups were statistical lower than the control group(P<0 .05) .Compared with the preoperative group and the postoperative group ,the incidence of hyperamylasemia in the whole group had significant difference(P<0 .05) .Compare witn the postoperative group ,the incidence of PEP in the whole group also had significant difference(P<0 .05) .Conclusion Use of somatostatin can reduce the incidence of PEP and hyperamylasemia ,and the use of somatostatin before and after the operation have a better preventive effect .

OBJECTIVE:To investigate the therapeutic efficacy of celecoxib in the treatment of knee osteoarthritis and its ef-fects on patin degree. METHODS:One hundred and twenty cases of knee osteoarthritis were selected from our hospital during Jan. 2014 to Jan. 2016,and then divided into control group and observation group according to therapy plan,with 60 cases in each group. Control group was given Ibuprofen sustained-release capsule 0.3 g,bid;observation group was additionally given lornoxi-cam 8 mg,bid,on the basis of control group. Both groups were treated for 4 weeks. VAS score was compared between 2 groups before and after treatment,and clinical efficacy and the occurrence of ADR were observed in 2 groups. RESULTS:There was no statistical significance in VAS score between 2 groups before treatment(P>0.05). After treatment,VAS score of 2 groups were de-creased significantly,and the observation group was significantly lower than the control group,with statistical significance (P<0.05). Clinical response rate of observation group was 95.0%,which was significantly higher than 75.0% of control group,with statistical significance (P<0.05). The incidence of ADR was 3.33% in observation group,which was significantly lower than 11.67% of control group,with statistical significance(P<0.05). CONCLUSIONS:Lornoxicam is effective for knee osteoarthritis and can significantly improve pain with good safety.

Objective To evaluate the effect and the incidence of adverse reaction of different chemotherapy combined with radiotherapy for the treatment of non-small cell lung cancer (NSCLC) complicated with type 2 diabetes.Methods A total of 123 midterm advanced NSCLC patients complicated with type 2 diabetes were randomly divided into A,B,C three groups through the random number generated by computer,and each group was 41 cases.Three groups of patients were treated with three-dimensional conformal radiotherapy and synchronous chemotherapy.Group A received gemcitabine and cisplatin,group B received paclitaxel and cisplatin,and group C received pemetrexed and cisplatin.The treatment efficiency,time to tumor progression,median survival time,survival rate and incidence of adverse reaction were observed and compared.Results The total effective rates of group A,B and C were 82.93％,78.05％ and 80.49％,with no statistically significant difference (x2 =0.365,P =0.357).The times to tumor progression of the three groups were (6.54 ± 1.23) months,(5.96 ± 1.27) months,(6.27 ± 1.08) months,with no statistically significant difference (F=1.235,P =0.314);the median survival times of the three groups were (16.54 ± 1.87) months,(15.36 ± 1.25) months,(16.29 ± 2.08) months respectively,with no statistically significant difference (F =2.226,P =0.245);1-year survival rates of the three groups were 80.49％,82.93％,85.37％ respectively,with no statistically significant difference (x2 =1.234,P =0.665);2-year survival rates were 48.78％,51.22％,43.90％,with no statistically significant difference (x2 =2.354,P =0.451).The incidence rates of radioactive pneumonia and bone marrow suppression in group C were 24.39％ and 24.39％,those were significantlylower than31.71％,53.66％ of group B (x2 =18.687 P=0.017;x2 =25.336,P=0.011) and 41.46％,31.71％ of group A (x2 =17.543,P=0.019;x2 =24.358,P =0.013).Conclusion The clinical efficacy of the three groups are similar,but the incidence rate of adverse reaction in pemetrexed and cisplatin plus radiotherapy group is the lowest.Therefore,pemetrexed plus cisplatin is the safe and effective treatment for the previously untreated patients with NSCLC.

Objective:To optimize the extraction process of berberine hydrochloride from Sanhuang Diyu oil by Box-Benhnken re-sponse surface methodology. Methods:The extraction process was optimized with the size of each medicine ( X1 ) , the liquid-solid ra-tio ( X2 ) and the extraction time ( X3 ) as the independent variables and berberine hydrochloride extraction amount ( Y) as the depend-ent variable, and the effects of variables and their interactions on the extraction efficiency were studied. Results:The experiment results indicated that the optimal extraction conditions were as follows:the size of each medicine was 60 meshes, the liquid-solid ratio was 18, and the extraction time was 1. 5 h. Under the above conditions, 3 batches of berberine hydrochloride from Sanhuang Diyu oil were ex-tracted. The average extraction rate of berberine hydrochloride was (16.6 ±0.6) mg·g-1(n =3). Conclusion: The extraction process of Sanhuang Diyu oil optimized by Box-Behnken response surface methodology is simple, stable and predictable.

"Humanity and virtue" is the core of Chinese traditional medicine ethics.The theories of "medicine is humane art" and "curing people with benevolence" were emphasized by Chinese doctors through the ages.According to the theory of the ancient doctors,the connotation of "humanity" is rich and profound,which is mainly embodied in two aspects-"humanity and virtue"of physicians and medical morality.The analysis and inheritance of "Humanity and virtue"of traditional Chinese medicine is of great signi cance for the construction of modern medicine.