Rats were kept in isobaric hypoxic chamber (O_2=10%)for ? , ? and 4 weeks(6h/day, 6days/week). The lung adrenoceptors were measured by radioligand bindingtechnique. Results showed that the ? adrenoceptor increased at 1st week of hypoxia and de-creased significantly at 2nd and 4th weeks of hypoxia. The change of ?_2 adrenoceptor wasconsistant with that of total ? adrenoceptor but the decrease was more significant. By con-trast, the ?_2 adrenoceptor increased significantly all the time. No change of Kd valuewas found in this study. The data indicated that the changes of adrenoceptors induced byhypoxia caused the domination of pulmonary vasoconstriction which may play a role inthe developement of hypoxic pulmonary hypertension.

Rats were kept in hypoxic chamber. Results showed that hypoxia led topulmonary hypertension and right ventricular hypertrophy, hypercapnia exasperated thishypertrophy but was not to hypertension. At the same time, lung ?_1-adrenoceptor all in-creased in hypoxia with or without hypercapnia groaps, ?-adrenoceptor increased after 1weekof hypoxia, and decreased after 1week and 2weeks of hypoxia with hypercapnia. These resultssuggested that the different type of adrenoceptors showed a different change after hypoxia.Results implied that the imbalance of adrenoceptor in lung might led to domination ofvaso-constriction caused by increased ?-adrenocepor, which might play the role in hypoxicpulmonary hypertension. The followed up increase of ?-adrenoceptor after 2weeks of hypoxiawith hypercapnia might be a compensative effect to eliminate exasperation of ventricular,hypertrophy.

〔Abstract〕 Based on various visual softwares, the paper mines the data of SCI papers and published patents on Eastern Equine En-cephalitis ( EEE) during 1995-2015.2, analyzes the overall development, patent technology life circle, research area, cooperation and competition among countries/districts, basic information of institutes or outstanding individuals.The characteristics of various visual soft-wares are showed, the libraries should master data mining and information visualization technology, so as to provide consulting service to satisfy the deep level and personalized demands of users.

After the concept, features and implementation types of storage virtualization technology were described, its application in storage management of library was studied.Storage virtualization technology can simplify the management of storage system, improve the utilization rate of storage equipments, and effectively solve the problems in storage management of library.

In order to show the development situation and trend in plaque research, Thomson Innovation Platform-covered application of patents associated with plaque researches was quantitatively analyzed using the Thomson Data Analyzer and Thomson Innovation or other tools, which revealed the overall development situation, the main accepted countries, the main application institutions and the technological direction layout of patents associated with plaque researches.

Objective To observe the relationship between hemoglobin (Hb) and vascular endothelial growth factor (VEGF) in serum of the patients with cancer. Methods Enzyme linked immunosorbent assay (ELISA) was used to detect VEGF levels in serum of the patients with cancers. Results The serum level of VEGF in the cancer group are significantly higher than that in the control group. The serum level of VEGF in patients with low level of hemoglobin ( 123.5 g/L) ( P

This article was aimed to study the acute toxicities on intragastric administration of differentRadix Aconiti Lateralis Praeparataprocessed products to Beagle dogs. A total of 16 healthy and qualified Beagle dogs were randomly divided into the blank group,Pao-Fu-Pian(PFP) group,Pao-Tian-Xiong(PTX) group andHei-Shun-Pian(HSP) group according to the body weight. The intragastric administration of 4 g crude herb per kg was given. Before medication, 1 h, 24 h, and 3, 7, 14 days after medication, the body weight, food consumption, rectal temperature, electrocardiogram, blood routine and blood biochemistry were measured. The results showed that after medication, all dogs in three experimental groups were depressed. And there were significant differences in the electrolytes of blood. Among them, the HSP group was the most obvious one. The red blood cells, blood sugar and triglycerides of dogs in the PFP group had significant difference. The lymphocytes and blood sugar had significant difference of dogs in the PTX group. However, after the medication of HSP, the lymphocytes of the dogs were decreased significantly. It was concluded that the toxicity of three processed products followed the order of HSP > PFP > PTX.

AIM:To investigate rat Urotensin-II(ra t U-II)-induced vasoconstriction of rat main pulmonary arteries and the role of mitogen-activated protein kinase(MAPK). METHODS: The main pulmon ary artery was dissected from the male Sprague -Dawley rats and artery ring width was 3-4 mm. Concentration-response curves wer e gene rated to rat U-II(0 03 nmol/L-30 nmol/L).Inhibitor of MAPK,PD 98059(0 1 ?mol/ L -10 ?mol/L) were added into the medium after rat U-II(30 nmol/L)induced vasoc onstriction had reached plateau to construct the relaxant concentration-respons e curves and their EC 50 and E max . RESULTS: Rat U-II was a potent vasoconstrictor of isolated rat main pulmonary arteries [EC 50 =7 95?0 4 0, E max =(14 28?6 34)% of the response to 60 mmol/L KCl]; PD 98059 caused c oncentration-dependent relaxations of rat U-II precontracted arteries [EC 50 =5 91?0 45, E max =(81 39?13 65)%]. CONCLUSION: Rat U- II was a potent vasoconstrictor of rat main pulmonary arteries and this response was med iated through MAPK.

Objective To analyze the institutional cooperation networks of 137 military hospitals in terms of published papers, trends of cooperation and co-authorship in order to guide the cooperation between military hospitals.Methods The institutional cooperation, co-authorship, author-keyword co-occurrence and author-subject co-occurrence in the 137 military hospitals were analyzed with the Thomson data analyzer( TDA) software.Results and Conclusion The institutional coop-eration between military hospitals could be divided into 5 types and were based on the principle of proximity of locations and similiarity of research.The cooperaiton circle with Chinese PLA General Hospital as the center was expanded over time. The institutional cooperation between military and civilian hospitals was also based on the principle of proximity of locations and similiarity of research.Cooperation between productive authors mainly occurred in the same research group but co-au-thorship outside the research group was scarce.The potential competition or cooperation between research fields and authors can be analyzed by comparing co-authorship and author-keyword co-occurrence.

The paper analyzes the current status and existing problems of citation retrieval work, puts forward the design principle, overall structure and function of cited references integration tools, demonstrates the key technologies of system realization.An integrated retrieval platform for online literature citations is constructed for the following functions:one-stop retrieval of various citation databases, automatic removal of duplications, so as to reduce the burden of staffs and improve efficiency effectively.