At present, coronary stent has been extensively used in clinic. It can significantly improve acute obstruction complication and vascular restenosis following percutaneous transluminal coronary angioplasty. However, restenosis also takes place after stent implantation, in particular for complex pathological changes. It has been demonstrated that thrombus, inflammation, and smooth muscle hyperplasia are three important stages for in-stent restenosis, and vascular intima hyperplasia is the major mechanism. After retrieving related articles, this paper discussed biocompatibility and restenosis of metal stent and drug-eluting stent, analyzed influence of stent implantation on collateral circulation function and inflammatory reactions, and explored the application of biodegradable stent.

OBJECTIVE:To investigate the compatible stability of cefepime dihydrochloride mixed with total parenteral nutrient(TPN). METHODS:Cefepime dihydrochloride mixed with TPN at room temperature for 24 h. The appearances of the mixture were observed at 0,2,4,6,8,10,24 h and the change of pH value was evaluated. The contents of cefepime dihydrochloride were determined by HPLC. RESULTS:No change was observed in the contents of cefepime dihydrochloride in total parenteral nutrient within 24 h. There was no significant change in the appearance,color and pH value of nutrient. CONCLUSION:At room temperature cefepime dihydrochloride in TPN is stable within 24 h.

Objective To investigate the correlation of serum adiponectin (APN),C-reactive protein (CRP) levels and carotid atherosclerosis plaque in patients with acute cerebral infarction (ACI).Methods Sixty patients with ACI (ACI group) were diagnosed by head CT and MRI examination.And sixty cases of healthy check-up were as control group.The serum APN and CRP were examined by double antibody sandwich enzyme linked immunosorbent assay method,and carotid atherosclerosis was examined by ultrasound.Results The serum APN and CRP levels in ACI group were (4.36 ± 2.54),(8.93 ± 2.89)mg/L,and in control group were (8.43 ± 3.51),(1.12 ± 0.52) mg/L.The serum APN level in ACI group was significantly lower than that in control group,and the serum CRP level in ACI group was significantly higher than that in control group (P ＜ 0.05).In ACI group,the serum APN level after treatment was significantly increased compared with that before treatment,the serum CRP level after treatment was significantly decreased compared with that before treatment.The differences were (6.44 ± 2.31) and (4.10 ± 0.72) mg/L respectively.The rate of carotid atherosclerosis in ACI group was 78.33％ (47/60),and the rate of carotid atherosclerosis plaque was 71.67％(43/60).The stable plaque was in 13 cases and instability plaque was in 30 cases.The rate of carotid atherosclerosis in control group was 26.67％(16/60),and the rate of carotid atherosclerosis plaque was 13.33％(8/60).The stable plaque was in 6 cases and instability plaque was in 2 cases.The differences between the two groups had statistical significance (P ＜ 0.05).In ACI group,the serum APN and CRP levels in ACI without carotid atherosclerosis plaque were (6.89 ± 2.37) and (5.41 ± 1.38)mg/L,in ACI with carotid atherosclerosis plaquewere (3.28 ± 1.99) and (9.42 ±3.70) mg/L.Carotid atherosclerosis plaque and serum APN level showed negative correlation (r =-0.76,P ＜ 0.05),and serum CRP level was positively correlated (r =0.81,P ＜ 0.05).The serum APN and CRP levels in ACI with stable plaque were (4.32 ± 2.14) and (6.65 ± 2.69) mg/L,in ACI with instability plaque were (2.11 ± 1.35) and (10.11 ± 3.82) mg/L.Carotid artery plaque stability and serum APN level showed negative correlation (r =-0.69,P ＜ 0.05),and serum CRP level was positively correlated (r =0.77,P＜ 0.05).Conclusions The occurrence of ACI is closely related to carotid atherosclerotic plaque.The serum APN level in ACI patients is significantly lower than that in normal crowd,but serum CRP level in ACI patients is significantly higher than that in normal crowd.The rate of carotid atherosclerosis is significantly increased,most of which is instability plaque.Carotid atherosclerosis plaque and serum APN level has negative correlation,and serum CRP level is positively correlated.Carotid artery plaque stability and serum APN level has negative correlation,and serum CRP level is positively correlated.

Objective To characterize the clinical features of patients with high level of carbohydrate antigen (CA)724 in order to facilitate the recognition of this clinical manifestations.Methods Eight-two cases of hospitalized patients diagnosed with gout were selected and divided into 2 groups according to the level of CA724,and the clinical features and laboratory indexes were compared between the 2 groups.T test was used in the numerical variable data between groups,x2 test was used in the categorical variable data.Correlation analysis was tested using Spearman analysis.Results The incidence of gout stones in the group with high level of CA724 was 61％,which was significantly higher than that in the group of normal CA724 of 28％.There were statistically significant differences between the two groups (x2=8.894,P＜0.05).The incidence of kidney stones in the group with high level of CA724 was 65％,which was significantly higher than that in the group of normal CA724 of 22％.There were statistically significant differences between the two groups (x2=15.013,P＜0.05).But there were no statistically significant differences in age of onset,blood uric acid,erythrocyte sedimentation rate,and serum creatinine between the two groups (P＞0.05).Conclusion The significantly elevated level of CA724 canappeare in gout patients,But it isnotcorrelated with tumor,which should be paid attention by clinician.It helps to avoid unnecessary checks and reduce the psychological and financial burden of patients.

Since human imprinted genes in 11P15.5 was found,it had been proved that various human physiological abnormality associated with it.As one of the first identified imprinted non-coding RNA genes,more attention is paid to lncRNA H19 by many scholars not only because it's linked with Beckwith-Wiedemann syndrome (BWS) and Russell syndrome (SRS),but also H19 gene is the only imprinted gene belonging to long non-coding RNA related with a variety of tumors which can also produce microRNA675 and lncRNA 91H coming from H19 gene antisense-coding.This paper will review possible mechanisms of H19 gene in tumorigenesis process and its research status in Cancer therapy from four aspects:imprinting feature,single nucleotide polymorphisms,lncRNA character and its possible action signal axis in cancer.

Objective:To study the effect of phillyrin on immune function in mice treated with cyclophosphamide.Methods: Mice model of immunosuppression was induced by intraperitoneal injection of cyclophosphamide,the mice in the experimental group received phillyrin with 50,100 and 150 mg/kg doses by gavage.While model group and control group received normal salin,all treatments continued 7 d.The thymus and spleen organ coefficients was measured by conventional methods.The phagocytosis of peritoneal macrophages was measured by FITC microspheres.The levels of IL-2,IL-4 and cAMP in peripheral blood were detected by ELISA.The effects of different doses of phillyrin on the above indexes were analyzed in immunosuppressed mice.Results: A mice model of immunosuppression was established after 7 d,the results showed that the immune organ index,phagocytic capacity of macrophages and the level of immune factors in serum could be improved,and the content of cAMP in peripheral blood lymphocytes was decreased in different degree by phillyrin.Conclusion: Phillyrin has the function of immune regulation,which can resist the immunosuppression of cyclophosphamide.

Objective To analyze and solve the difficulties in rapidly expanding the mobile field hospital in earthquake relief mission.Methods Aimed at the difficulties in the speed,advance men were sent out before the expansion.Then the personnel were regrouped in the proceeding of the expansion,and the vehicles entered the district according to the predefined area and order.Results The expanding speed was raised.Conclusion The scheme meets the requirements of the first aid in the mobile field hospital.

Objective To investigate the variations of hepatic artery and its extrahepatic arteries on hepatic arteriogram and to provide benefit for transhepatic arterical chemoemblization.Methods The hepatic arteriograms of 200 cases with unresectable hepatic malignant tumor before interventional therapy were analysed.Two interventional radiologists in common reviewed the incidences of various types according to Michels' classification,the absence of proper hepatic artery,and the variations of extrahepatic arteries originating from hepatic artery.Results The most common hepatic artery variation was Michels type Ⅲ(n=17,8.5%),followed by type Ⅱ(n=10,5.0%) and Ⅴ(n=9,4.5%).Proper hepatic absence was found in 25 cases and appeared as 5 subtypes.5 kinds of extrahepatic arteries were found.The most common extrahepatic artery was the right gastric artery(n=156,78.0%),followed by cystic artery(n=126,63.0%),accessory left gastric artery(n=19,9.5%),the hepatic falciform artery(n=5,2.5%),and accessory left inferior phrenic artery(n=4,2.0%).Conclusion There are some other variations of hepatic artery beside Michels' classification,and there are many variations of extrahepatic arteries originating from hepatic artery,it is important to assure interventional therapy effect for hepatic cancer and prevent complication.

Objective To study the effects and advantages of the treatment for simple bone cysts of the long bones in children with AO titanium elastic nail and autologous bone marrow injection. Methods Eighteen patients with a simple bone cyst at humerus or femur were managed with AO titanium elastic in-tramedullary nail combined with autologous bone marrow injection. There were eleven boys and seven girls in total, with the mean age of 8.1 years, ranged from 6 to 12 years. Twelve cysts was located in the proximal end of humerus, five in the proximal end of femur and one in the middle part of the shaft of femur. Twelve cysts were active and six inactive according to Neer standard. Radiographic evaluation was performed three, six, twelve and eighteen months after operation during the 11 to 23 months follow-up by taking anteroposteri-or and lateral X-ray pictures. Then we measured residual radiolucent areas on X-ray pictures and did statistic research with group comparison. Results Six cysts (33.3%) healed completely, and twelve (66.7%) healed with residual radiolucent areas which were visible on X-ray pictures 3 to 6 months after operation. Residual radiolucent areas on X-ray pictures gradually reduced during the different phases and it has statistical signif-icance by group comparison. There was no recurrence or major complication except for one patient with mild irritation of skin caused by the end of the nail up to now. Conclusion The treatment for simple bone cysts of the long bones in children combined with AO titanium elastic nail and autologous bone marrow injection not only has satisfactory healing rate but also can provide early stability to the long bones, and accelerate the healing of cysts which allows early mobilization and thus obviates the long-term need for a plaster cast and decreases the prevalence of the most common complication: a pathological fracture.