Objective: To investigate the clinical value and significance of B ultrasonography guiding percutaneous gallbladder catheterized drainage (PGCD)in elder patients with acute chole-cystitis. Methods: The clinical data of 34 elder patients with acute cholecystitis in our hospital who were treated with PGCD were analysed retrospectively, and comparing with those clinical data of 22 elder patients with acute cholecystitis in our hospital during the same period who were treated with traditional gallbladder removal operation, and these data were evaluated with statistical analysis. Results: The incidence rate of postoperative complications and death rate in the group of elder patients with acute cholecystitis who were treated with PGCD were 0, the average stay was 18.2 days. The incidence rate of postoperative complications in the group of elder patients with acute cholecystitis who were treated with traditional gallbladder removal operation was 40.9% , the death rate of this group was 13.6% , and the average stay was 23.7 days. Statistical analysis confirmed that the difference of incidence rate of postoperative complications, death rate and average stay between these two treatments have statistical significance. Conclusion: Ultrasonography guiding PGCD is a safe, effective and easily operating method for the first treatment plan treatment of elder patients with acute cholecystitis.

Objective:To explore the correlation between lymph node metastasis rate and prognosis in non-small cell lung cancer (NSCLC) patients with stage Ⅲ A/N 2. Methods:The clinical data of 350 NSCLC patients with stage Ⅲ A/N 2 receiving surgical treatment from January 2012 to June 2015 in Shanxi Provincial Cancer Hospital were retrospectively analyzed. The patients were divided into the high lymph node metastasis rate group and the low lymph node metastasis rate group according to the optimal cutoff value of lymph node metastasis rate determined by Cox hazard regression model. The relationship between clinicopathological features and lymph node metastasis rate was analyzed. Prognostic risk factors were analyzed by using Cox regression model, and overall survival (OS) and disease-free survival (DFS) of both groups were analyzed by using Kaplan-Meier method. Results:The optimal cutoff value of lymph node metastasis rate was 0.2. There were 180 cases with high lymph node metastasis rate (>0.2) and 170 cases with low lymph node metastasis rate (≤0.2). The proportion of the patients with adenocarcinoma and the highest lymph node metastasis in the high lymph node metastasis rate group was higher than that in the low lymph node metastasis rate group [72.2% (130/180) vs. 52.9% (90/170), 52.8% (95/180) vs. 29.4% (50/170), all P<0.05]. The proportion of patients with jumping N 2 lymph node metastasis, single station N 2 lymph node metastasis and single station N 2 lymph node metastasis in the highest group was lower than that in the low lymph node metastasis rate group [51.1% (92/180) vs. 71.8% (122/170), 25.0% (45/180) vs. 44.1% (75/170), 38.9% (70/180) vs. 75.3% (128/175), all P<0.05]. Cox multi-factor regression model analysis showed that adenocarcinoma, multiple stations N 2 lymph node metastasis, lymph node metastasis rate were independent risk factors of DFS for NSCLC patients with stage Ⅲ A/N 2 ( HR = 2.201, 95% CI 1.444-3.355; HR=2.971,95% CI 1.950-4.529; HR=3.543, 95% CI 1.874-6.699; all P<0.05). Lymph node metastasis rate was an independent risk factor of OS for NSCLC patients with stage Ⅲ A/N 2 ( HR = 3.669, 95% CI 1.941-6.938, P<0.05). The 5-year OS rate of the low lymph node metastasis rate group was higher than that of the high lymph node metastasis rate group (64.00% vs. 36.58%, χ2 = 11.422, P = 0.001). The 5-year DFS rate in the low lymph node metastasis rate group was higher than that in the high lymph node metastasis rate group (45.00% vs.18.32%, χ2 = 13.624, P<0.01). Conclusion:Lymph node metastasis rate is an independent influencing factor for the prognosis of NSCLC patients with Ⅲ A/N 2 stage, and it can effectively evaluate the prognosis.

Objective:To investigate the clinical efficacy and economic effect of Alprostadil in the pharmacotherapeutic scheme for cerebral infarction.Methods:A total of 156 successfully treated cases of cerebral infarction were selected from those admitted from March 2003 to March 2004 and divided into two pharmacotherapeutic groups,with Alprostadil given to Group Ⅰ.The data were evaluated and compared by pharmacoeconomic cost-effect analysis.Results:The costs were $11 271.47 and $8 147.06,and the effectiveness rates were 84.21% and 70.00% respectively in the two groups,with the cost-effect ratios of 133.86 and $114.34 / unit effectiveness.It cost $219.87 for Group Ⅰ to increase a unit of effectiveness over Group Ⅱ.Conclusion:Group Ⅰ had a higher effectiveness rate,while Group Ⅱ a lower cost-effect ratio.

Objective To develop LabVIEW-based digital PCG analyzer. Methods A kind of Digital PCG analyzer based on LabVIEW was designed. It included a heart sound sensor, an analog filtering circuit and amplifying circuit, an AD converter, a digital data transferring model and a software for PCG analyzing. Meanwhile, a kind of 3-lead ECG sampling circuit and a display model in LabVIEW were designed as a reference signal for PCG. distinction. Results This digital PCG analyzer had the functions of heart sound sampling from body surface, PCG real-time displaying on the software, spectrum analyzing for the PCG data and PCG database managing. Conclusion This kind of digital PCG analyzer based on LabVIEW can be used for assistant diagnosis of cardiac Arrhythmia and cardiac abnormal noise, and as a teaching tool for clinical auscultation.

OBJECTIVE:To observe the efficacy and safety of Shexiang zhenggu tincture combined with Huoxue zhitong pow-der in the treatment of acute traumatic swelling and pain. METHODS:Totally 160 patients with acute traumatic swelling and pain were randomly divided into group A and group B. Patients in group A were given Shexiangzhenggu tincture for external use,3 times a day;patients in group B were orally added one bag of Huoxue zhitong powder,3 times a day,based on the treatment of control group. 7 d was course and it lasted 2 courses. The clinical efficacy,the scores of visual analogue pain score (VAS) and swelling remission before and after 7 and 14 d treatment and the incidence of ADR were observed. RESULTS:After 7 d treatment, the total effective rate in group A was significantly higher than group B,with significant difference(P<0.05);after 14 d treat-ment,there was no significant difference in the total effective rate between 2 groups (P>0.05). After 7 and 14 d,the scores of VAS and swelling remission were significantly lower than before;14 d treatment was lower than 7 d treatment,and group B was significantly lower than group A after 7 d treatment,with significant differences (P<0.05);there were no significant differences among the scores of VAS and swelling remission in 2 groups after 14 d treatment (P>0.05). No obvious ADR was found in 2 groups during treatment. CONCLUSIONS:Shexiang zhenggu tincture combined with Huoxue zhitong powder has better efficacy, can relieve the pain and swelling faster,with similar safety.

OBJECTIVE:To observe the efficacy and safety of amlodipine besylate combined with Xinkeshu in the treatment of hypertension. METHODS:100 patients with hypertension were randomly divided into control group (50 cases) and observation group(50 cases). Control group was orally given one Amlodipine besylate tablet,once a day;observation group was additionally given 4 Xinkeshu tablets,3 times a day. The treatment course was 8 weeks. Clinical efficacy,systolic blood pressure(SBP)and di-astolic blood pressure(DBP)before and after treatment in 2 groups were observed,the incidence of adverse reactions was record-ed. RESULTS:The total effective rate in observation group was significantly higher than control group,the incidence of adverse re-actions was significantly lower than control group,the differences were statistically significant (P<0.05). Before treatment,there were no significant differences in the SBP and DBP between 2 groups (P>0.05). After treatment,the SBP and DBP in 2 groups were significantly lower than before,the differences were statistically significant(P<0.05);but there was no significant difference between 2 groups (P>0.05). CONCLUSIONS:The efficacy of amlodipine besylate combined with Xinkeshu is superior to amlo-dipine besylate alone in the treatment of hypertension,with better safety.

Objective To evaluate the clinical value bronchofiberscope and perfusion in the treatment of multi- drug resistant pulmonary tuberculosis (MDR-TB).Methods Forty-two cases were treated by injecting amikacin (0.4 g), ofloxacin (0.4 g), after cleaning up exudation through bronchofiberscope and catheter intervention combined with chemotherapy therapy, while 37 controls were treated by chemotherapy only.Results By the end of 9 months, the sputum tubercle bacillus conversion rate, radiographical improvement rate were 92.9% and 90.5% respectively in the treated groups,while all these indications were higher than those of control group 62.2% and 59.5% (P

Objective To investigate the frequencies of variant of lipoprotein lipase(LPL)gene,HindIII site at intron 8 and PvuII site at intron 6,and its relation with type 2 diabetes mellitus and insulin resistance(IR).Methods PCR-RFLP method was used to determine the DNA polymorphism of 8 th intron and 6 th intron of LPL gene in 78 T2DM patients and 49 controls.Results(1)Compared with control group,the frequencies of H+H+ genotypes and alleles ″H+″ was significantly higher in type 2 diabetes patients(P

Objective To study the drug retention of HPC MMC in bladder after intravesical instillation. Methods The pharmacokinetics of the intravesical mucous adhesive anticancer agent HPC MMC in urine and in tissue were comparatively studied with conventional mitomycin C aqueous solution(S MMC) by means of animal experiment. Results After instillation, the half life of MMC in urine in the 2 groups was 2.61 h and 0.56 h and in tissue 2.33h and 0.46 h respectively. Conclusions Suggesting that HPC MMC remained longer within the urinary bladder. It may be therapeutically more efficient.

Objective]Help students to construct the system of TCM clinical thinking and to cultivate the ability of differential diagnosis and prescription. [Methods]In the late clinical teaching, make junior doctor with a high grade of students, graduate students, or some clinical experience as a research object, designing as a medical record has gradually evolved into a number of different medical records dynamic group, let students practice the tentacles medical records. [Results]Gradually,students learned to distinguish the different parties in the different clinical symptoms, and enhance the understanding of drugs and prescriptions. [Conclusion] The tentacles medical records practicing can cultivate the students' ability of dialectical thinking integration.