Objective To analyze the correlation of serum hs‐CRP and IL‐6 levels with cerebral hemorrhage volume and nerve function damage .Methods One hundred and two cerebral hemor‐rhage patients served as an experimental group and 64 individuals undergoing physical examina‐tion served as a control group in this study .The patients in experimental group were further di‐vided into mild damage group (n= 29) ,moderate damage group (n= 42) ,severe damage group (n=31) ,10 ml hemorrhage group(n=15) ,10 -30 ml hemorrhage group (n=52) ,and >30 ml hemorrhage group (n=35) .Their serum hs‐CRP and IL‐6 levels were measured on days 1 ,5 ,10 and 15 after admission .Results The serum hs‐CRP and IL‐6 levels in experimental group in‐creased gradually in the first 5 days ,reached their peak on day 5 and then decreased gradually (P<0 .05) .The serum hs‐CRP and IL‐6 levels were significantly higher in severe damage group than in mild and moderate damage groups ( P<0 .05) ,and in experimental group than in control group (9 .46 ± 1 .26 mg/L vs 4 .24 ± 0 .94 mg/L ,P=0 .02) .Conclusion The serum hs‐CRP and IL‐6 levels are related with cerebral hemorrhage volume and nerve function damage ,and can thus be considered as an important parameter in clinical testing .

Objective:To explore the relationship between friendship quality and loneliness and its influent factors like the measuring tool of friendship quality,the participants groups and cultural background. Methods:The studies on the association between the friendship quality and loneliness were collected through the databases of Chi-na National Knowledge Infrastructure,Wan Fang,Wiley Online library,Web of Science,Google Scholar and Duxiu from 1984 to 2014. Meta-analysis was conducted with the use of the CMA2. 0. Estimated value (r)and their 95%confidence interval (95%CI)was calculated to analyze the association between the friendship quality and loneliness from normal subjects except physiological disease (such as autism,etc. ). Results:Totally 46 literatures were met the requirements of meta-analysis with sample size of 19422,including 24 researches With 11846 participants who were from eastern countries,and 22 studies with 7676 western people. There was significant negative correlation of friendship quality and loneliness (r=-0. 28,95%CI:-0. 23--0. 32). The friendship quality measuring tool was able to adjust the relations of friendship quality and loneliness (Q=11. 95,P<0. 01). The participants groups had a regulatory role on the relationship between the friendship quality and loneliness (Q=19. 54,P<0. 001). Under dif-ferent cultural background of the subjects,the relationship between their friendship quality and loneliness was notsignificant difference (Q=0. 05 ,P>0. 05 ). Conclusion:It suggests that friendship quality has an influence on lone-liness. Measuring tools and subjects groups effect the relationship friendship quality and loneliness except cultural background.

Objective To evaluate the cooperative effect of intraperitoneal adenoviral p53 gene therapy together with thymosin ?1 against peritoneal carcinomatosis. Methods KM mouse model bearing peritoneal carcinomatosis was established using H22 cell line. 48 hours after inoculation, adenoviral-mediated p53 gene was administrated intraperitoneally alone, or combined with thymosin ?1 within 7 days. The abdominal girth, body weight, tumor cell number, apoptosis and cell cycle were tested using methods of cell counting and flow cytometry. Results Adenoviral p53 gene transfer alone arrested H22 cell in G0/G1. In combination therapy group, ascitic fluid was obviously halted, tumor cells in peritoneal cavity decreased in number and ascites formation, dead cell ratio was elevated. Conclusion Adenoviral-mediated p53 gene could block cell proliferation. Intraperitoneal adenoviral p53 gene therapy combined with thymosin ?1 showed synergism for the lethal damage and inhibition for peritoneal carcinomatosis.

Background and purpose:There is a tendency to treat tumors through multiple genes and multiple targeting but there has been no reports about the therapeutic effect of recombinant human endostatin(ES)combined with rAd/p53 on graft model of human breast cancer.Methods:MCF-7 human breast cancer cells were inoculated in nude mice.Then the nude mice with xenograft tumor were randomized into groups of control,ES,rAd/p53,and ES + rAd/p53,they were treated according to the plan.Diversity of the xenograft tumor volume and side effect was observed.Microvessel density(MVD)and expression of vascular endothelial growth factor(VEGF)were detected by immunohistochemistry.Results:After the administration of ES,rAd/p53,ES + rAd/p53,the growth of tumor was inhibited with the inhibitory rate of 1.75%,43.36% and 58.68%,respectively.Inhibition of tumor growth was significant in Group rAd/p53 and ES + rAd/p53(P0.05).Conclusions:recombinant human endostatin combined with rAd/p53 can greatly inhibit growth of xenograft tumor,and reduce the generation of capillary vessels.

Objective: To compare the quality of life before and after artificial mechanical heart valve replacement. Methods: From February to June 1998, 115 patients (56 males, 59 females) underwent mechanical valve replacement. The investigation table was filled in one week before the operation and three months postoperatively. Results: There was a notable improvement in patient's physical strength, activity ability, emotion aspect and society home life after operation (P=0.000). In patients with valve-related complications, 64% complained inconvenience in purchasing anticoagulant medicines in the locality, while in patients without valve-related complications, only 39% have such experience. There was significant difference between two groups (P=0.034). 86% of patients with complications worry about the possibility bleeding, while in those with no complications only 55% (P=0.006). Conclusion: Mechanical prosthetic valve replacement significantly improves patient's physical strength, activity ability, emotion and society-home life.

Objective:To investigate the inhibitory effect of recombinant human endostatin(ES)combined with rAd/P53 on transplanted human breast cancer cell MCF-7 in nude mice.Methods:Animal breast cancer model was established by inoculating MCF-7 cells in nude mice.The animals were randomized into control group,ES group,rAd/P53 group,and ES+ rAd/P53 group.The tumor growth was observed in each group and immunohistochemical method was employed to examine the microvessel density(MVD) and the expression of vascular endothelial growth factor(VEGF).Results:Tumor growth was significantly inhibited in all the 3 treatment groups(P

Objective To define the indications and evaluate the results of various surgical treatment options in patients with nonparasitic hepatic cysts. Methods The clinical data of 284 patients with nonparasitic hepatic cysts treated in our hospital from January 1995 to December 2005 were retrospectively analyzed. Results Percutaneous aspiration and sclerotherapy were performed in 161 cases and complications occurred in 9 (5.59%), recurrence in 53 (32.92%) and the mortality was 0%.Open surgery was conducted in 71 cases and the complications occurred in 16 (22.54%), recurrence in 8 cases (11.27%) and the mortality was 2.82%. Laparoscopic surgery was employed in 52 cases and complications occurred in 7 ( 13.46%), recurrence in 6 (11.54%) and the mortality was 1.92%.Conclusion There is currently no general agreement in the literature concerning when nonparasitic hepatic cysts should be treated. Laparoscopic surgery was more favorable than other therapeutic options.However, we should choose individually suitable methods according to different clinical symptom of patients.

Objective To evaluate the safety of central lymph node dissection with total thyroidectomy for papillary thyroid carcinoma. Methods A meta-analysis on the data of suitable seven clinical researches was performed using the Mantel-Haenszel method and the risk difference was calculated.Results Seven studies with a total of 1524 patients were eligible for inclusion, 620 were with totalthyroidectomy plus central lymph node dissection and 904 with thyroidectomy alone. There was a significant increased risk of temporary hypocalcaemia ( P = 0. 03 ) and temporary vocal cord palsy ( P = 0. 01 ) when central lymph node dissection was performed in addition to a thyroidectomy. However, the risk of permanent hypocalcaemia( P = 0. 32 ) and permanent vocal cord palsy (P = 0. 75 ) has no statistical difference between the two groups. Conclusion Central neck dissection added to thyroidectomy does not increase rate of permanent morbidity in thyroid cancer patients.

Objective To revise the trait self-control scale for Chinese college students.Methods According to the theory,12 items were selected,then data were collected from a sample of 549 and 133 college students of Harbin.Explorer Factor Analysis,Confirmatory Factor Analysis,reliability test and validity test were used.Results ①Trait self-control scale for college students included eight items,two dimensions were restrained and impulsivity,two dimensions can explain 42.90％ of the total variance.②Confirmatory Factor Analysis showed that the two-dimensional structure was reasonable (x2/df =1.24,CFI =0.97,GFI =0.96,AGFI =0.92,IFI =0.97,TLI =0.96,RMSEA =0.04).③The restrained factor scores were positively correlated with satisfaction of life scores and adaption scores(r=0.23,0.48,P＜0.01),while negatively correlated with negative affect (r=-0.19,P ＜0.01).The impulsivity factor scores were negatively correlated with satisfaction of life scores and adaption scores (r=-0.18,-0.34,P＜0.01),while positively correlated with negative affect(r=0.22,P＜0.01).④The composite reliability coefficients of the scales were good:the coefficient of the subscale restraint was 0.69,and the coefficient of subscale of impulsivity was 0.64,the coefficient of the whole scale was 0.80.The two months test-retest reliability coefficient of 133 subjects was 0.66.Conclusion The revised scale of trait self-control scale has good psychometric quality and can be used in Chinese college students.

Objective To investigate the guidance of a new classification on the treatment methods selection for cystic dilation of bile duct (CDBD).Methods The clinical data of 213 patients with CDBD who received treatment according to the Todani 2003 classification at the Peking Union medical College Hospital from September 1968 to July 2013 were retrospectively analyzed.The CDBD was reclassified with a new classification proposed by Dong Jiahong et al,and the guidance of the new classification on the treatment methods selection for CDBD was analyzed.Patients were followed up via out-patient examination and telephone interview till August 2013.Results Of the 213 patients,139 were with Todani type Ⅰ CDBD (type C CDBD of the new classification) ; 3 were with Todani type Ⅱ CDBD (type C1 CDBD of the new classification) ; 1 was with Todani type Ⅲ CDBD (type E CDBD of the new classification); 52 were with Todani type Ⅳa CDBD (35 with type D1 and 17 with type D2 CDBD of the new classification) ; 1 was with Todani type Ⅳb CDBD (type C CDBD of the new classification) ; 8 were with Todani typeⅤ-Ⅰ CDBD (type B CDBD of the new classification) ; 9 were with Todani type Ⅴ-Ⅱ CDBD (type A CDBD of the new classification).Eighteen patients did not receive the surgical treatment.Of the 195 patients who received surgical treatment,patients with type C and D CDBD of the new classification took a large proportion.Patients with type C CDBD of the new classification received cystectomy,biliary cyst resection,Rouxen-Y cholangiojejunostomy or internal drainage.Patients with type D CDBD of the new classification received extrahepatic biliary cyst resection,Roux-en-Y cholangiojejunostomy.Patients with severe intrahepatic disease and with type D1 CDBD of the new classification received concomitant left hemihepatectomy or pancreaticoduodenectomy.Patients with type A1 CDBD of the new classification received right hemihepatectomy.Patients with type A2 CDBD of the new classification were cured by conservative treatment after split liver transplantation.Patients with type B1 CDBD of the new classification received left hemihepatectomy and Roux-en-Y cholangiojejunostomy.Patients with type B2 CDBD of the new classification received bile duct stone extraction.There was 1 patient with type E CDBD,and partial resection of the CDBD ± bile duct reconstruction was carried out.Pancreatic fistula,biliary fistula,reflux cholangitis,cholangitis and anastomotic stricture were detected on 74 patients,and they were cured by conservative treatment or lithotomy.A total of 187 patients were followed up with the median time of 85 months (range,1-432 months).One hundred of seventy-five patients recovered well,and 12 patients with canceration of the bile duct died of tumor metastasis at postoperative 1-282 months.Conclusion This new classification simplifies the typing of extrahepatic bile duct dilation,refines the typing of intrahepatic bile duct dilation,and has better guidance for surgical treatment.