1.Advances in Molecular Biology in Gliomas(review)
Chinese Journal of Rehabilitation Theory and Practice 2007;13(5):446-449
Malignant gliomas represent the largest group of brain tumors in humans. Recent studies have explored the molecular changes and apoptosis on gliomas, which involved the molecular etiology malignant progression, molecular subtyping, gene therapy, and prognostic evaluation of gliomas. This paper reviewed the relevant advances in the field of gliomas molecular biology.
2.Measurement of Gastric Volume Before and After Laparoscopic Sleeve Gastrectomy
Chinese Journal of Minimally Invasive Surgery 2016;16(9):855-857
[Summary] Laparoscopic sleeve gastrectomy ( LSG) as a sole and definitive bariatric surgery has achieved well results in terms of decreasing the body mass index ( BMI ) and percentage of excess weight loss (%EWL ) , therefore reducing the obesity-related complications , but the mechanism remains unclear .As a restrictive surgical procedure , the most important mechanism of LSG might be the reduction of the volume of the stomach resulting in a limited food intake .Therefore, to achieve the best weight loss after surgery , measuring the gastric volume is an indispensable technology .Currently, gastric capacity measurement methods include imaging measurements and intraoperative direct measurement . Imaging methods include upper gastrointestinal radiography , CT three-dimensional reconstruction , MRI and radionuclide scanning , with each having its advantages and disadvantages .In this article, the measurement methods of gastric capacity before and after LSG were reviewed .
3.Influence analysis of full-thickness continuous suture method and layer interrupted suture method in emergency abdominal operation closure
Chinese Journal of Postgraduates of Medicine 2014;37(23):31-34
Objective To assess the influence of full-thickness continuous suture method and layer interrupted suture method in emergency abdominal operation closure.Methods Two hundred and thirtyseven patients of emergency abdominal operation were divided into full-thickness continuous suture method group (145 cases) and layer interrupted suture method group (92 cases) according to the suture method.The rate of incision liquefaction and infection,time of incision suture were compared between the 2 groups,the patients with incision liquefaction and infection were given bacterial culture.Results The time of incision suture in full-thickness continuous suture method group was significantly shorter than that in layer interrupted suture method group [(18.37 ± 7.42) min vs.(25.92 ± 5.79) min],there was statistical difference (P <0.01).There were no statistical differences in the rate of incision liquefaction and infection,the rate of incision primary healing between the 2 groups (P > 0.05).In full-thickness continuous suture method group,the rate of incision liquefaction and infection in median incision was significantly lower than that in rectus abdominis incision [18.58% (21/113) vs.31.25% (10/32)],the rate of incision primary healing was significantly higher than that in rectus abdominis incision [81.42% (92/113) vs.68.75% (22/32)],there were statistical differences (P < 0.05).In layer interrupted suture method group,there were no statistical differences in the rate of incision liquefaction and infection,the rate of incision primary healing between median incision and rectus abdominis incision [33.33% (23/69) vs.26.09%(6/23),66.67% (46/69) vs.73.91% (17/23),P > 0.05].The rate of incision liquefaction and infection in median incision of full-thickness continuous suture method group was significantly lower than that in median incision of layer interrupted suture method group,and the rate of incision primary healing was significantly higher than that in median incision of layer interrupted suture method group,there were statistical differences (P < 0.05).There were no statistical differences in the rate of incision liquefaction and infection,the rate of incision primary healing in rectus abdominis incision between the 2 groups (P > 0.05).The bacterial culture result in patients with incision liquefaction and infection showed positive was in 26 cases,in full-thickness continuous suture method group was in 10 cases (6.90%,10/145),in layer interrupted suture method group was in 16 cases (17.39%,16/92),there was statistical difference (P <0.05).The mostly bacterial of infection was Escherichia coli.Conclusions The full-thickness continuous suture in median incision can shorten operative time and reduce the rate of incision liquefaction and infection in emergency abdominal operation.Suture technique has important impact on incision healing.
4.Effects and possible mechanisms of baicalin on the atherosclerosis rabbits
Chinese Journal of Clinical Pharmacology and Therapeutics 2000;0(02):-
AIM:To investigate the effects and possible mechanisms of baicalin on the atherosclerosis rabbits.METHODS:Thirty healthy New Zealand white rabbits were divided randomly into five groups:normal control group(A group,n=6)and fed with normal diet,atherosclerosis model group(B group,n=6),baicalin therapic group(C group,n=6),bacalin preventive group(D group,n=6),and positive control group(E group,n=6),the last four groups fed with hypercholesterol diet for 12 weeks.Treated with bacalin 300 mg/(kg?d),and simvastatin 5 mg/(kg?d)additionally for 2 weeks in C and E group respectively from the tenth week.Treat with bacalin 100 mg/(kg?d)for 12 weeks in D group.Serum lipids and liver lipids were detected with standard enzymatic assays.Atherosclerotic plaque/intima size ratio of area and NF-?B content in blood vessel tissue were examined.Enzyme-linked immunosorbent assay(ELISA)was employed to monitor the levels of serum TNF-?,IL-1? and Adiponectin.RESULTS:Atherosclerotic plaque/intima size ratio of area decreased in C,D and E group than in B group(P
5.Study on respiratory drive and respiratory function of patients with cerebral infarction
Xiaodong ZHU ; Hui MA ; Yan CHENG
Chinese Journal of Neurology 2008;41(11):738-741
Objective To detect P0.1 and respiratory function of patients with cerebral infarction(CI)and analyze the effect of cerebral infarction on respiratory function. Methods Arterial blood gases, respiratory drive and lung function were measured in 35 cases with CI and 15 healthy controls. The figures were analyzed by SPSS 10.0. Results The PaO0.2 (mm Hg, 75.80±4.12, 1 mm Hg=0.133 kPa), SaO2(%,94.97±0.78) and Plmax(kPa,4.076±2.443) were lower than those in the healthy control group (88.68±3.77, 96.40±0.48 and 7.747±0.599,t=-8.310,-5.731,-5.439,all P=0.000). P0.1 max and P0.1/MV in the CI group were lower than those in the healthy control group;the P0.1 did not have significant difference in these two group; the P0.1/P0.1max and P0.1/Plmax in the CI group were significantly higher than those in the healthy control group; the PImax was correlated with PO2, O2sat, P(A-a) O2, P0.1max, P0.1, P0.1,/PImax, P0.1/P0.1max, FVC, FEV1.0 and PEF; the PEmax was correlated with P0.1/ PImax, FVC, FEV1.0 and PEF. Conclusion The respiratory function of patients with CI has been impaired, the oxygenated index is cut down and the respiratory drive and respiratory drive store are decreased.
6.Determination of telomerase activity in carcinoma of bile duct and its clinical significance
Xiaodong GU ; Kuansheng MA ; Zhenping HE
Journal of Third Military Medical University 2001;23(5):582-583
Objective To explore the relationship between te lomerase activity and bile duct carcinoma and its significance in clinical diag nosis. Methods Telomerase activities were examined in 23 cases of bile duct carcinoma, 5 cases of carcinoma adjacent tissues and 5 cases of nor mal bile duct tissues respectively with telomerase PCR-ELISA method. Results Telomerase activity was detected in 18 of 23 cases (78.3%) of b ile duct carcinoma, and was not found in 5 cases of carcinoma adjacent tissues a nd 5 cases of normal bile duct tissues. The detection rate of telomerase activit y had no correlation with patients' age, sex, tumor site and size but significan tly correlated to metastasis of tumor (P<0.05). Conclusion The level of telomerase activity was significantly higher in bile duct carcino ma and may be served as one of the clinical marker for malignant neoplasm becaus e of its spsecificity.
7.Role of cancer-associated fibroblasts in growth and metastasis of hepatocellular carcinoma
Dening MA ; Xiaodong ZHU ; Zhaoyou TANG
Journal of Clinical Hepatology 2014;30(9):865-868
The development and progression of tumors are closely related to the tumor microenvironment.As one of the most important com-ponents in tumor microenvironment,cancer-associated fibroblasts (CAFs)play an important role in carcinogenesis,angiogenesis,inva-sion,and metastasis of tumors.The role of CAFs in the development and progression of hepatocellular carcinoma (HCC)is reviewed by dis-cussing how CAFs are recruited and activated in the tumor microenvironment and how CAFs promote tumor angiogenesis and regulate tumor immunity.This review may provide new approaches for the treatment of HCC.
8.Discussion of mechanisms of rats with depression in Parkinson′s disease treated with Chaigan Jieyou decoction
Dandan MA ; Chunye ZHENG ; Xiaodong LUO
The Journal of Practical Medicine 2014;(23):3732-3735
Objective To build rat models and observe changes of behavior and monoamine of PDD. Methods The rats were injected with 6-OHDA and accepted CUMS for the establishment of PDD model , so as to assess its behavior changes and detect brain tissue monoamine contents by ELISA. Results Significant behavioral and monoamine abnormalities can be observed in model rats. Behavioral and monoamine improvement can be observed after treated with Chaigan Jieyou. Conclusion The PDD model can be established by 6-OHDA and CUMS. Chaigan Jieyou decoction may reach therapeutic purposes by increasing monoamine contents.
9.Experimental Study of Tongluoningxinfang Decoction Protection on Human Umbailical Vein Endothelial Cells
Li MA ; Yingzhi YAO ; Xiaodong ZHANG
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(04):-
Objective To observe the protecting effect of Tongluoningxinfang decoction on human umbilical vein endothelial cells. Methods To cultivate endothelial cells and prepare serum with Tongluoningxinfang decoction and Fufangdanshenwan,cells were randomly separated into 8 groups,normal group,model group,treat group (high dose,medium dose,low dose),control group (high dose,medium dose,low dose). Except normal group,add 30% H2O2 to the other groups,and make endothelial cells damaged models. Add serum with drugs to treat groups and control groups,and test NO,ET-1 and P-selection (Ps) respectively. Result NO of model group was significantly lower than normal group,all treat groups and all control groups. ET-1 of model group was significantly higher than all treat groups and all control groups. Ps of model group was significantly higher than normal group,treat groups (smedium dose,low dose) and control groups (high dose,medium dose). It had no significant difference compared with model group,treat group (high dose) and control group (low dose). Conclusion Tongluoningxinfang decoction has the same influence as Fufangdanshenwan on secretion of vein endothelial cells. Tongluoningxinfang decoction and Fufangdanshenwan all can prevent vein endothelial cells from damage induced by H2O2.
10.Comprehensive correction of secondary unilateral cleft lip nasal deformity using autologous cartilage and supported by septum cartilage
Xiaodong MA ; Wei CAO ; Li HUANG
Chinese Journal of Medical Aesthetics and Cosmetology 2017;23(4):246-248
Objective To study the surgical method of comprehensive correction of secondary unilateral cleft lip nasal deformity using autologous cartilage and supported by septum cartilage and its outcomes.Methods Our surgery adopted an open approach,fully revealed the deformed alar cartilage and deviated nasal septum cartilage.Part of the nasal septum was removed and made it into various cartilage grafts to repair and reconstruct the columella,nasal tip,nasal alar and nasal dorsal by implanted in the corresponding positions.Results 18 patients with congenital unilateral cleft lip nasal deformity underwent the corrective and reconstructive surgery.The postoperative follow-up was 6-12 months,showing that the malformed nasal appearance came back to normal without obvious scar.The 18 patients did not have associated complications.Conclusions The surgery with a supplementary septal graft achieves good effect,the overall appearance of the malformed nose gets obvious changes,and therefore patients and their families are satisfied with the postoperative nasal shape.