Objective To investigate the correlation between CT grading and prognosis of hypoxic-ischemic encephalopathy(HIE),and with the diagnostic value of CT findings and followed-up.Methods 49 neonates from 1 month to 1 year with HIE whose CT findings and followed-up results and clinic were retrospectively analyzed.Results Among 49 cases,the clinical follow-up showed that the hypodense foci induced by HIE were absorbed and disappeared completely within 1～3 months after birth.10 neonates presented external hydro-cephalous at 1～3 months after birth and then that was absorbed after 6 months to 1year of age.In 3 months,the part poor moderate HIE in the neonates might cause the leukomalaria,while severe HIE might cause the cerebral malaria and atrophy within 1 month after birth.Conclusion The prognosis of HIE is closely related to the degree of abnormal manifestations on CT.Intracranial lesions were favorable in the mild HIE,good in the moderate ones and bad in the severe ones.If there were bleeding in ventricles,the prognosis would be more poor.