1.Superfine Mineral Dust and Human Health
Journal of Environment and Health 1992;0(05):-
Most solid materials in nature consist of minerals, they are ubiquitous on the surface of the earth. After inhaled in body, they will trigger pulmonary disease. The pathogenesis of mineral dusts is always in the way of disputing and consummating. Researcher should pay great attention to the adverse effect of mineral dust in nonprofessional environment. The biological action of mineral surface is an important aspect to discover mineral dust interface function and molecular toxicological mechanism. At present, the superfine mineral dust and nanometer suspending dust are the important components of dust environment safety assessment.
2.Multi-slice spiral CT features of crush pulmonary parenchymal injuries in the massive Wenchuan earthquake
Zhihui DONG ; Zhigang YANG ; Yuan LI ; Xiaochun ZHANG ; Qiling WANG
Chinese Journal of Radiology 2009;43(5):486-489
Objective To evaluate the multi-slice spiral CT (MSCT) features of crush pulmonary parenchymal injuries in the massive Wenchuan earthquake. Methods One hundred and seventeen patients with crush pulmonary parenchymal injuries in the massive Wenchuan earthquake were reviewed, the location, extent and MSCT appearances of the injuries and associated thoracic injuries were evaluated. The MSCT appearances of the injuries on 1 d, 2--5 d and 6--14 d were compared using Chi-square test. Results One hundred and thirteen patients had pulmonary contusion and bilaterally in 70 cases, 7 had pulmonary laceration. A total of two hundreds and eighty-three lung lobes were involved and 3 or more lobes involved in 47 patients. Ill-defined patchy opacity was detected in 75 patients, associated ground-glass opacity (GGO) in 24 cases. Lung laceration presented as pneumatocele in 4 cases and demarcated hematoma in 3 cases. Coexisted rib fractures were detected in 98 patients and flail chests were in 29 patients. Forty-three patients had coexisted fractures of scapula, clavicle and (or) sternum. Ninety-nine patients had coexisted pleural injuries. Conclusions Crush pulmonary parenchymal injuries in the Wenchuan earthquake are severe. The bilateral, multifocal and multiple lobes involved injuries with a high incidence of coexisted other severe thoracic injuries are the noticeable features.
3.Operative treatment of compound acetabular fractures through single posterior approach with percutaneous eannulated screws and reconstruction plates
Dong WANG ; Shuhua YANG ; Xiaochun WEI ; Haiyu SUN
Chinese Journal of Orthopaedic Trauma 2008;10(7):615-618
Objective To discuss the efficacy of a modified single posterior fixation of complicated acetabular fractures with a percutaneous cannulated screw and a reconstruction plate in comparison with traditional bilateral approaches (ilioinguinal and Kocher-Langerbeek). Methods From April 2004 to May 2007, 48 cases of complicated acetabular fracture were treated surgically. By Letoumel classification, 22 were transverse and posterior wall fractures, 16 fractures of both columns, 3 fractures of anterior column and posterior wall, 3 T shape fractures and 4 anterior column and posterior hemi-transverse fractures. Of them, 22 cases were treated through the bilateral approaches and 26 cases through the modified single posterior approach by which a percutuneous cannulated screw was applied, going askew through skin and ischial tuberosity, to fix the anterior column and a reconstruction plate to fix the posterior column. Results Forty patients were followed up for 6 to 37 months(average, 18 months) . There was no statistical difference between the 2 groups as fax as the following factors were concerned: anatomic reduction rate and functional good-to-excellent rate. But there were significant differences in operation time and volume of hemorrhage during operation. Conclusion In treatment of complicated acetabular fractures, the modified singl eposterior approach simplifies traditional bilateral approaches so that surgery procedures, perioperative bleeding and postoperative complications can be reduced without sacrificing the treatment efficacy.
4.Application of a self-assembly adjustable traction frame for patients with severe trauma and ;fracture of lower limb in ICU
Yinglan DONG ; Mingming WANG ; Xiaochun LIU ; Qiaoyun ZHANG ; Jianfang WEI
Chinese Journal of Practical Nursing 2016;32(32):2514-2517
Objective To introduce a self- assembled adjustable traction frame for the patients with severe trauma and lower limb fracture in ICU, compared with Brawns traction frame. Methods 96 patients with severe trauma and lower limb fracture diagnosed by clinical signs and X-ray who had to be transferred to ICU were randomly divided into the study group (46 cases) and the control group (50 cases) by sealing letters method.The study group were tracted by the self-assembled adjustable traction frame, and the control group were tracted by the Brawns traction frame. The fracture alignment, degree of pain, incidence of pressure ulcers, nursing limit time of changing the sheets of the two groups were observed. Results The results declared that 37 cases with 2 pain score points, 9 cases with 0-1 points in the study group and 19 cases with 2 pain score points, 3 cases with 0-1 points, 28 cases with Grade 3 in the control group (χ2=38.683, P<0.01). In the control group, pressure ulcer were occurred, 5 of them at Level one, 1 of them at Level two, 1 of them at Level three and the incidence rate was 14.00% (7/50). In the study group, pressure ulcer were occurred, 1 of them at Level two and the incidence rate was 2.17%(1/46). The pain level and incidence of pressure sore in the study group were decreased and the difference between the two groups was significant (χ2=8.197, P < 0.05). Conclusions The self-assembly adjustable traction rack can not only ensure the same effect as the Brawns traction frame but also reduce the deficiency caused by Brown traction frame. It is safer and more comfortable for the patients and can reduce nursing complications and improve the quality and efficiency of the nursing work.
5.Management of chronic acromioclavicular joint dislocation with hook plate and fascia lata graft
Lilin ZHU ; Dong HUANG ; Weichi WU ; Xiaochun LIU ; Chaoqun YU
Chinese Journal of Orthopaedic Trauma 2016;18(6):542-544
Objective To evaluate the therapeutic efficacy of hook plate and fascia lata graft in management of chronic acromioclavicular joint dislocation.Methods From May 2012 to March 2014,a total of 16 cases of chronic acromioclavicular joint dislocation (Rockwood type Ⅲ) were treated with hook plate and fascia lata graft.They were 10 men and 6 women,from 19 to 57 years of age (mean,34.7 years).Seven cases were at the left side and 9 at the right side.All injuries resulted from direct violence.The time from injury to surgery ranged from 8 to 54 weeks (mean,12.4 weeks).At the final follow-ups,the shoulder function was assessed using the Quick Version of the Disabilities of the Arm,Shoulder and Hand Score (DASH) and visual analogue scale (VAS),and the efficacy using Karlsson's evaluation system.Results All surgical wounds primarily healed.The dislocation of acromioclavicular joint was corrected,without any vascular or neural damage.The patients were followed up for an average of 12 months (from 6 to 18 months).No plate breakage,screw loosening or redislocation was observed.The DASH and VAS scores of the shoulder at the final follow-ups (25.42 ± 8.34 and 2.22 ± 1.70,respectively) were significantly improved,compared with the preoperative ones (43.72 ± 12.35 and 6.33 ± 1.37,respectively) (P < 0.05).According to the Karlsson's criteria,10 cases were excellent,4 good and 2 moderate.Conclusion In management of Rockwood type Ⅲ chronic acromioclavicular joint dislocation,hook plate and fascia lata graft can restore dynamic balance and stability of the acromioclavicular joint,resulting in solid fixation,early joint motion and limited complications.
6.Epidemiological analysis of reported emergency public health events at schools in Tianjin from 2006 to 2013
Qian CHEN ; Xiaochun DONG ; Jinbo GOU ; Meiling SUN
Tianjin Medical Journal 2015;43(5):548-551
Objective To analyze the epidemiological characteristics of reported emergency public health events at schools from 2006 to 2013, and provide a scientific basis for better disposal of school-related events. Methods The reported emergency public health events at schools in Tianjin from 2006 to 2013 were collected, and descriptive epidemiological analysis was conducted on data. Results A total of 267 reported emergency public health events at school in Tianjin during 2006-2013, of which 257 infectious disease events, accounting for 96.25%. The incident occurred in primary schools and nurseries. The peak was from March to June and October to December for the incident. The top three species of disease onset were influenza (2 360 cases), chicken pox (2 032 cases) and mumps (1 813 cases). There was a correlation between the duration and interval from onset of the first case to report of emergency public health events(rs=0.522,P<0.05). Conclusion In recent years, school public health emergency events are high momentum, mainly in rural areas, primary schools and nurseries. Timely detection and disposal of emergency public health events can reduce the harm generated by them.
7.Unilateral Orthofix external fixation for tibial defects
Yongjun HUANG ; Dong HUANG ; Yiheng JIANG ; Weichi WU ; Hao LIN ; Xiaochun LIU
Chinese Journal of Orthopaedic Trauma 2017;19(7):634-636
Objective To explore the curative effects of unilateral Orthofix external fixation in the treatment of tibial defects.Methods From June 2012 to February 2016,we treated 19 patients with tibial defects using unilateral Orthofix external fixation.They were 14 men and 5 women,aged from 26 to 79 years (mean,43.0 years).The right tibia was involved in 12 cases and the left tibia in 7.The soft tissue defects averaged 6.4 cm × 3.7 cm.The mean bone defect before bone transport was 8.9 cm in length.The anteroposterior and lateral X-ray films of the affected tibia were taken regularly after surgery.Edwards tibial fracture scores were used to evaluate the functional recovery and complications of the affected limb at final follow-ups.Results All the patients were followed up for 10 to 40 months (average,18.5 months).Bone union time ranged from 4 to 16 months (average,9.0 months).Lengths of bone transport ranged from 6 to 10 cm (average,7.8 cm).All the bone defects were reconstructed.According to the Edwards scoring at the final follow-ups,10 cases were rated as excellent,6 as good and 3 as poor.Complications were observed in 4 cases,giving a complication rate of 21.1%.Conclusion Unilateral Orthofix external fixation and bone transport can lead to preferable curative effects in the management of tibial defects.
8.The effects of ethyl pyruvate on high mobility group box-1 protein expression in murine severe acute pancreatitis
Zhenggang LUAN ; Zhongye HE ; Cheng ZHANG ; Ming DONG ; Xiaochun MA ; Renxuan GUO
Chinese Journal of General Surgery 1993;0(03):-
Objective To explore the effects of ethyl pyruvate (EP) on high mobility group box-1 protein (HMGB1) expression in severe acute pancreatitis (SAP) rats.Methods Ninety male wistar rats were divided randomly into three groups: Group A (SAP group); group B (SAP rats received ethyl pyruvate therapy); group C (control group). Specimens from rats in the three groups were taken at 3, 6, 12, 24 and 48 h after operation respectively. The concentration of plasma amylase and D-lactate the activity of malonyl dialdehyde (MAD) in the intestinal tissue were determined. The changes of morphological damage of intestinal tissue was observed by microscopy. The expression of HMGB1 in intestinal mucosa was observed by SP immunohistochemistry and the activity of HMGB1 was determined by western blot.Results Compared with group A, Ievels of plasma amylase, and D-lactate in group B decreased markedly (P
9.Extra-organic primary tumor in pelvis: correlation of multi-detector row computed tomography, anatomy and pathology.
Zhihui DONG ; Zhigang YANG ; Yuan LI ; Pengqiu MIN ; Xiaochun ZHANG
Journal of Biomedical Engineering 2009;26(1):75-79
The purpose of this study was to investigate the correlation between multi-detector row CT (MDCT) features, pathological findings and the anatomic basis of extra-organic primary tumors in pelvis so as to improve the document diagnosis of these entities. We retrospectively analyzed the MDCT manifestations of 20 cases with surgically and/or pathologically evidenced diagnoses of extra-organic primary tumors in pelvis. The results showed that, in 14 cases, the tumors were located in the pelvis, and 6 of them involved both pelvis and hypogastric zone. There were 8 tumors located in the peritoneal cavity of the pelvis, and 3 of them also involved the extraperitoneal space of the pelvis. In the peritoneal cavity, 2 tumors of male patients were located in the rectovesical pouch while 3 tumors of female patients were located in the rectouterine pouch. The majority of entities in these 2 pouches were germ cell tumors (3/5 cases, 60.0%). In the extraperitoneal space, 5 of 12 tumors were located in the pararectal space and 5 of them were located in the retrorectal space. The majority entities of these 10 cases were germ cell tumors (7/10 cases, 70.0%). Lymphoma mainly involved paravesical and pararectal space in disorder. Calcification occurred in 6 cases, including 4 cases of teratoma, 1 case of neurilemmoma, and 1 case of malignant teratoma. The fatty element occurred in 7 masses, including 4 cases of teratoma, 1 case of malignant teratoma, 1 case of mixed germ cell tumor, and 1 case of liposarcoma. MDCT with multi-planar reconstruction (MPR) could more clearly reveal the anatomic location of the extra-organic primary tumor in pelvis, could unveil the tumor's relationship with its surrounding organs, and could help to differentiate benign tumors from malignant tumors.
Adolescent
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Adult
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Aged
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Child
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Child, Preschool
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Female
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Humans
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Imaging, Three-Dimensional
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Infant
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Male
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Middle Aged
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Pelvic Neoplasms
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diagnostic imaging
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pathology
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Retrospective Studies
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Teratoma
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diagnostic imaging
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pathology
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Tomography, Spiral Computed
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Young Adult
10.Synthesis and biological evaluation of noscapine analogues as microtubule-interfering agents.
Houling DAI ; Jianbin ZHENG ; Min LIN ; Jing ZHENG ; Fusheng ZHOU ; Xiaochun DONG ; Lei GUO ; Jianwen LIU ; Ren WEN
Acta Pharmaceutica Sinica 2012;47(10):1347-57
A series of noscapine analogues have been synthesized via 13-step reaction starting from 2-hydroxy-3-methoxybenzaldehyde. Anti-tumor activities of these compounds were evaluated against HL-60 cell lines in vitro by the standard MTT assay. It was found that most of these derivatives showed appreciable inhibitory activity against HL-60 and tubulin polymerization. The results also indicated that the potency of compound 31 is about three times more than that ofnoscapine against HL-60 cell line and tubulin polymerization. Moreover, it induced a massive accumulation of cells in G2/M phase. These results showed noscapine and its derivatives were worth to be intensively studied further.