1.Effects of hypertriglyceridemia on NO, ET-1 and the grade of the pathology severity in rats with severe acute pancreatitis
Xiaochen ZENG ; Xiangying WANG
Journal of Chinese Physician 2011;13(7):900-902
Objective To explore influence of hypertriglyceridemia on serum NO ET-1 and the grade of the pathology severity in rats with severe acute pancreatitis. Methods 36 SD rats were randomly divided into 2 groups, group A (HLSAP group) , group B (SAP group). Severe acute pancreatitis was constructed by retrograde injection of 5% na-taurocholate. Blood samples were taken from all subjects to measure triglyceride, ET-1 and NO, pancreatic tissue samples were taken from head of pancreas and stained with H. E. , the degree of pancreatic damage was observed according to the point score of Schmidt and Pozsar's methods. Results In group A, the concentration of ET-1 increased more obviously than that in group B at 4 hour and 8 hour period(P <0. 05). The concentration of NO declined both in group A and group B at 12 hours period,but it had a great decline in group A. Animals with hyperlipidemia and severe acute pancreatitis developed significantly higher(P <0. 05) ET-1 than the animals of the non-hyperlipamic severe acute pancreatit group in 4 hours and 8 hours period. NO declined in group A and group B at 12 hours period, group A have significantly higher(P <0. 05) decline than group B in NO. The histological degree of pancreatic damage were significantly higher in group A than that in the group B at all times. Conclusions Mircrocirculation disorder had existed disorder in the early of SAP. Hypertriglyceridemia could incrase ET-1 and NO earlier and higher in severe acute pancreatitis, and then decline in the late stage. Hypertriglyceridemia intensified the pathologichistological degree of pancreatic damage.
2.Experimental Study on Jiaweizhiyu Decoction in Treating Diabetic Peripheral Neuritis
Wenjuan WANG ; Xiaochen ZHANG ;
Chinese Traditional Patent Medicine 1992;0(02):-
Objective: To syudy the pharmacologic and clinical effects of Jiaweizhiyu Decoction.Methods: The decoction for relieving pain, reducing blood sugar and controlling thrombus formation was investigated.Results: Jiaweizhiyu Decoction has effects on relieving pain, reducing blood sugar and controlling thrombus formation.Conclusion: It will be further researched for us.
3.Reform of Traditional Rehabilitation Technique Teaching in Higher Vocational Education
Chinese Journal of Rehabilitation Theory and Practice 2010;16(5):499-500
Based on the characteristics and objectives of three-year rehabilitation therapy in higher vocational education, this paper discussed the reform of content, teaching mode, methods and appraise system in the course of traditional rehabilitation technique.
4.Effect of Functional Electrical Stimulation on Postoperative Treatment of Lumbar Disc Herniation
Wenjuan WANG ; Xiaochen ZHAO ; Wei WANG
Journal of China Medical University 2015;(12):1087-1089
Objective to investigate the efficacy of functional electrical stimulation(FES)on the postoperative treatment of lumbar disc hernia-tion. Methods Informed consents were obtained from all the subjects before the study. totally 60 patients who had remnant nervous lesion after sur-gery of lumbar disc herniation were divided into two groups:FES group and Control group. FES group received treatment since the first day after sur-gery. the parameters of therapeutic apparatus were as follows:35 Hz,0.28 ms,1 time daily and 30 min each time. the intensity of the treatment was the maximum tolerated that the patients can take. the course was 4 weeks. the control group during the study did not receive any stimulation. the myodynamia of hallux dorsiflexion and JOA score of patients were recorded and analyzed. Results After 2 weeks treatment,the myodynamia of FES group was 15.10±5.03,which was significantly larger than that of the control group at 12.03±6.30(P < 0.05). After 4 weeks treatment,the myody-namia of FES group was 20.43±5.73,which was significantly larger than that of the control group at 14.57±7.17(P < 0.05). After 4 weeks of treat-ment,the JOA score of FES group was 24.63±1.91,which was significantly higher than that of the control group at 19.87±2.33(P < 0.05). Conclu-sion After 2-4 weeks of functional electrical stimulation therapy,myodynamia of hallux dorsiflexion in FES group was significantly improved. And at the 4th week after operation,JOA score was more higher than that of the control group. Functional electrical stimulation in the treatment of remnant nervous lesion after postoperative of lumbar disc herniation has exact curative effect,which is worthy of popularization.
5.Teaching Reform of Rehabilitation Assessment in Higher Vocational Education Rehabilitation Treatment Technology
Liyan WANG ; Xiaochen WANG ; Lingyan LI
Chinese Journal of Rehabilitation Theory and Practice 2011;17(6):596-597
Based on talented person admittance standard and train objective, considering student's cognition characteristic and the professional rank test and so on in higher vocational education rehabilitation treatment technology, this paper explored reform and construction of rehabilitation assessment.
6.Investigation about immune function of red blood cell in patients with hemodialysis
Jing WANG ; Xiaochen FENG ; Bihu GAO
Clinical Medicine of China 2012;28(9):942-945
ObjectiveTo investigate the expression levels of the red blood cell surface receptors and oxidative stress of patients with hemodialysis,evaluate the immune function of the red blood cells,and identify the cause of infection and high prevalence of tumor in patients with hemodialysis.MethodsForty-five long-term hemodialysis patients from our blood purification center was chosen as the treatment group.Forty-five healthy individuals conducting physical examination at the same period was chosen as the control group.The flow cytometric method was used to detect CD35 surface receptors numbers of the red blood cell.The red blood cells wreath experiments were used to measure the adhesive function.The ELASA method was used to test the changes of oxidative stress index:SOD,MDA,CAT and GSH-PX.ResultsCompared to the normal control group,the treatment group had significantly lower levels of CD35 [ ( 28.62 ±6.95 ) AU vs.( 19.71 4.89) AU,t =5.441,P <0.01 ],impaired adhesive function red blood cells[ (0.63 ±0.07) vs.(0.44 ±0.04),t =0.41,P <0.05].For the levels of oxidative stress index,MDA [ ( 6.18 ± 0.16 ) μmol/L vs ( 13.47 ± 0.39 ) μmol/L ] was significantly higher in the treatment group than in the normal control group( t =13.14,P < 0.05 ),and SOD( 34 202.00 ± 1634.00) U/( g · Hb),CAT ( 21.70 ± 0.84 ) U/ml and GSH-PX ( 444.00 ± 10.31 ) U/ml were significantly lower in the treatment group than in the normal control group [ SOD:(24 652.00 ± 2179.00)U/( g · Hb),CAT:( 14.80 ± 1.13 ) U/ml,GSH-PX:( 217.89 ± 13.70 ) U,t =20.246,9.496,27.195,P <0.05 ].ConclusionPatients with hemodialysis had lower numbers of red blood cell surface receptors CD35 and impaired immune function of adhesion,and higher oxidative stress levels.This may be the cause of infection and tumor of patients with hemodialvsis.
7.Curriculum Construction of Occupational Therapy Technique in Higher Vocational Education
Xuezhen MA ; Xiaochen WANG ; Yi CHEN
Chinese Journal of Rehabilitation Theory and Practice 2012;18(8):789-790
Occupational therapy technique is one of the core curriculums of rehabilitation treatment profession. Curriculum construction of occupational therapy technique will have a direct impact on students' quality. This article introduced the reform in the process of curriculum construction from aspects including the curriculum standards, textbooks, teaching methods and course evaluation.
8.A analysis on the effect of PRVC mode of ventilator for mechanical ventilation efficiency
Xiaochen SI ; Yan WANG ; Lan QIN
China Medical Equipment 2017;14(5):34-37
Objective:To analyze the advantages of the pressure-regulated volume control (PRVC) mode compared with the traditional continuous mandatory ventilation (CMV) mode about mechanical ventilation efficiency of ventilator.Methods: For the mechanical ventilation situations, the parameters of PRVC mode, V-CMV mode and P-CMV mode under same detecting conditions were tested by using gas analyzer, which based on the ventilation principle of PRVC mode. And then the differences between PRVC mode and CMV modes were analyzed. Results: PRVC mode can supply the almost same tidal volume, and provide lower pressure and higher compliance compare with the V–CMV mode under the same conditions. On the other hand, PRVC mode can supply more tidal volume and slightly higher compliance compare with the P–CMV mode under the same pressure.Conclusion: PRVC mode has combined with the advantages of CMV mode, and it can make sure the target tidal volume, at the same time, reduce the pressure of airway, and improve the compliance for circuit. It also can make the mechanical ventilation to got more efficiency and more safety.
9.The effects of thermocycling on the tensile bond strength of silicone denture liner incorporated with silver-nano-particles
Meng WANG ; Huaiqin ZHANG ; Xiaochen LU
Journal of Practical Stomatology 2014;(5):709-711
16 standered acrylic resin blocks with silicone resilient denture liner(10 mm ×8 mm ×3 mm)incorporated with nano-silver par-ticles at 5% (m/m,by dry wet)in-between were prepared.8 blocks were immersed in distilled water for 24 h at 37 ℃ as the controls (group 1).Another 8 were thermocycled for 4 000 cycles(group 2).16 acrylic resin bars were thermal cycled for 4 000 cycles.Then they were processed exactly as the control group (group 3).Tensile bond strength of the specimens was measured by a universal testing machine. The bond strength values(MPa)of group 1,2 and 3 were 2.683 ±0.435,2.179 ±0.633 and 1.460 ±0.566 respectively(group 1 vs 2,P>0.05;group 3 vs 1 or 2,P<0.05).The failure mode of the blocks in group 1 and 2 was mainly cohesive failure,in group 3 adhesion fail-ure.
10.Reform of Teaching for Higher Vocational Rehabilitation Therapy
Yi CHEN ; Xuezhen MA ; Xiaochen WANG
Chinese Journal of Rehabilitation Theory and Practice 2013;19(3):296-297
This article introduced the reform of the teaching mode for Rehabilitation Therapy in higher vocational education, including the course of theory and practice, system of personnel training and assessment.